公开(公告)号：US5234635A

公开(公告)日：1993-08-10

申请号：US595473

申请日：1990-10-11

申请人： Jean-Francois Grollier ,  Georges Rosenbaum ,  Isabelle Richoux ,  Francisco Chiodi ,  Jacky Burlin

发明人： Jean-Francois Grollier ,  Georges Rosenbaum ,  Isabelle Richoux ,  Francisco Chiodi ,  Jacky Burlin

IPC分类号： A61K8/00 ,  A61K8/14 ,  A61K8/33 ,  A61K8/36 ,  A61K8/37 ,  A61K8/39 ,  A61K8/42 ,  A61K8/49 ,  A61K8/67 ,  A61K8/73 ,  A61K9/127 ,  A61K31/505 ,  A61K31/535 ,  A61P17/00 ,  A61Q5/00 ,  A61Q7/00

CPC分类号： A61Q7/00 ,  A61K31/505 ,  A61K8/14 ,  A61K8/4953 ,  A61K8/671 ,  A61K9/127 ,  A61K9/1272 ,  A61K9/1277 ,  Y10S436/829 ,  Y10S514/88 ,  Y10S514/881 ,  Y10S514/963 ,  Y10S516/928

摘要： To prepare an aqueous dispersion of lamellar lipid vesicles, at least one lipid is dissolved in at least one water-immiscible organic solvent; the organic phase thus obtained is added to an aqueous phase in such amounts that a dispersion of the oil-in-water type is obtained by vigorous stirring; the evaporation of the solvent(s) is carried out with vigorous stirring, the continuous phase of the dispersion always remaining the aqueous phase; and, should it become necessary, the dispersion is concentrated. The process can be carried out at low temperature (of the order of 35.degree. to 55.degree. C.), which makes it possible to encapsulate in the aqueous phase or to introduce into the vesicle sheets heat-sensitive active substances; the lipid concentration in the organic phase can reach up to 50% by weight.

摘要翻译： 为了制备层状脂质囊泡的水性分散体，将至少一种脂质溶于至少一种与水不混溶的有机溶剂中; 将这样得到的有机相加入到水相中，使得通过剧烈搅拌获得水包油型的分散体; 在剧烈搅拌下进行溶剂的蒸发，分散体的连续相总是保留水相; 如果有必要，分散集中。 该方法可以在低温（约35℃〜55℃）下进行，这使得可以将其包封在水相中或引入囊泡片热敏活性物质中; 有机相中的脂质浓度可达50％（重量）。