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    Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
    4.
    发明授权
    Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders 失效
    提供载脂蛋白A-1激动剂的基因治疗方法及其用于治疗血脂异常的疾病

    公开(公告)号：US07250407B2

    公开(公告)日：2007-07-31

    申请号：US10991217

    申请日：2004-11-16

    申请人： Jean-Louis Dasseux ,  Renate Sekul ,  Klaus Büttner ,  Isabelle Cornut ,  Günther Metz ,  Jean Dufourcq

    发明人： Jean-Louis Dasseux ,  Renate Sekul ,  Klaus Büttner ,  Isabelle Cornut ,  Günther Metz ,  Jean Dufourcq

    IPC分类号： A61K31/70 ,  C07H21/04

    CPC分类号： A61K48/005 ,  A61K38/00 ,  A61K48/00 ,  A61K51/08 ,  C07K14/775

    摘要： The invention relates to genetic approaches to supply nucleotide sequences encoding modified forms of the native forms of apolipoprotein A-I (ApoA-I): mature ApoA-I, preproApoA-I and proApoA-I; including native ApoA-I modified to contain ApoA-I agonists, peptides which mimic the activity of ApoA-I; ApoA-I superagonists, peptides which exceed the activity of native ApoA-I; and modified native ApoA-I having one or more amphipathic helices replaced by the nucleotide sequences of one or more ApoA-I agonists; for the treatment of disorders associated with dyslipoproteinemia, including cardiovascular disease, atherosclerosis, restenosis, hyperlipidemia, and other disorders such as septic shock.

    摘要翻译： 本发明涉及提供编码载脂蛋白A-I（ApoA-I）的天然形式的修饰形式的核苷酸序列的遗传方法：成熟ApoA-I，preproApoA-I和proApoA-I; 包括修饰为含有ApoA-1激动剂的天然ApoA-I，其模拟ApoA-I的活性的肽; ApoA-I超级拮抗剂，超过天然ApoA-I活性的肽; 和具有由一个或多个ApoA-1激动剂的核苷酸序列替代的一个或多个两亲性螺旋的修饰的天然ApoA-I; 用于治疗与脂蛋白血症相关的疾病，包括心血管疾病，动脉粥样硬化，再狭窄，高脂血症和其它疾病如败血性休克。

    Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
    9.
    发明授权
    Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders 失效
    提供载脂蛋白A-1激动剂的基因治疗方法及其用于治疗血脂异常的疾病

    公开(公告)号：US06518412B1

    公开(公告)日：2003-02-11

    申请号：US08940136

    申请日：1997-09-29

    申请人： Jean-Louis Dasseux ,  Renate Sekul ,  Klaus Büttner ,  Isabelle Cornut ,  Günther Metz ,  Jean Dufourcq

    发明人： Jean-Louis Dasseux ,  Renate Sekul ,  Klaus Büttner ,  Isabelle Cornut ,  Günther Metz ,  Jean Dufourcq

    IPC分类号： C07H2102

    CPC分类号： A61K48/005 ,  A61K38/00 ,  A61K48/00 ,  A61K51/08 ,  C07K14/775

    摘要： The invention relates to genetic approaches to supply nucleotide sequences encoding modified forms of the native forms of apolipoprotein A-I (ApoA-I): mature ApoA-I, preproApoA-I and proApoA-I; including native ApoA-I modified to contain ApoA-I agonists, peptides which mimic the activity of ApoA-I; ApoA-I superagonists, peptides which exceed the activity of native ApoA-I; and modified native ApoA-I having one or more amphipathic helices replaced by the nucleotide sequences of one or more ApoA-I agonists; for the treatment of disorders associated with dyslipoproteinemia, including cardiovascular disease, atherosclerosis, restenosis, hyperlipidemia, and other disorders such as septic shock.

    摘要翻译： 本发明涉及提供编码载脂蛋白A-I（ApoA-I）的天然形式的修饰形式的核苷酸序列的遗传方法：成熟ApoA-I，preproApoA-I和proApoA-I; 包括修饰为含有ApoA-1激动剂的天然ApoA-I，其模拟ApoA-I的活性的肽; ApoA-I超级拮抗剂，超过天然ApoA-I活性的肽; 和具有由一个或多个ApoA-1激动剂的核苷酸序列替代的一个或多个两亲性螺旋的修饰的天然ApoA-I; 用于治疗与脂蛋白血症相关的疾病，包括心血管疾病，动脉粥样硬化，再狭窄，高脂血症和其它疾病如败血性休克。