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公开(公告)号：US08652445B2
公开(公告)日：2014-02-18
申请号：US11173632
申请日：2005-06-30
申请人： Jeff MacDonald , Robert Hayman
发明人： Jeff MacDonald , Robert Hayman
摘要： A one-component prescription fluoride treatment composition having both fluoride efficacy and sensitivity relief is disclosed. The composition includes at least one metal fluoride and a nerve desensitizing agent such as potassium nitrate. The invention further includes a composition having at least one metal fluoride less than about 1.15% by weight of at least one metal fluoride; less than about 5 percent by weight of at least one alkali metal salt having desensitizing effect; at least one carrier; and at least one foaming agent that has thickening property. The composition may be formulated into a gel, a paste or any other convenient form, some of which contain abrasives.
摘要翻译： 公开了具有氟化物功效和灵敏度的单组分处方氟化物处理组合物。 该组合物包括至少一种金属氟化物和神经脱敏剂如硝酸钾。 本发明还包括一种组合物，其具有至少一种金属氟化物，其至少少于一种金属氟化物的1.15重量％ 少于约5重量％的至少一种具有脱敏作用的碱金属盐; 至少一个载体; 和至少一种具有增稠性的发泡剂。 组合物可以配制成凝胶，糊剂或任何其它方便的形式，其中一些含有研磨剂。
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公开(公告)号：US20080050408A1
公开(公告)日：2008-02-28
申请号：US11926776
申请日：2007-10-29
申请人： Robert Hayman , Nancy Quan , Jeff MacDonald
发明人： Robert Hayman , Nancy Quan , Jeff MacDonald
摘要： A whitening system has a de-sensitizing effect as well as re-mineralizing capability. The system may be a one-component or a two-component composition. The system may also be an unfoamed, a foamed or a foamable composition. For a one-component system, a sparingly soluble calcium phosphate salt may be in dry particle form with at least one gelling agent, wherein the salt is capable of sustained release of both calcium and phosphate ions into saliva upon exposure of the particle thereto and providing a hydroxyapatite remineralization. In a two component system, a first component has at least one peroxide compound, at least one source of phosphate and at least one gelling agent; and a second component has at least one source of calcium, strontium and/or mixtures thereof. The second component may also contain at least one gelling agent, and the composition maybe present as a foam or is foamable. The composition may be packed in a two-compartment syringe, or be present in a carrier or coated onto a substrate.
摘要翻译： 美白系统具有去敏化作用以及再矿化能力。 该系统可以是单组分或双组分组合物。 该系统也可以是未发泡的，发泡的或可发泡的组合物。 对于单组分体系，微溶磷酸钙盐可以具有至少一种胶凝剂的干颗粒形式，其中所述盐在颗粒暴露时能够将钙和磷酸根离子缓慢释放到唾液中并提供 羟基磷灰石再矿化。 在双组分体系中，第一组分具有至少一种过氧化物化合物，至少一种磷酸盐源和至少一种胶凝剂; 并且第二组分具有至少一种钙，锶和/或其混合物来源。 第二组分还可以含有至少一种胶凝剂，并且该组合物可以以泡沫形式存在或者是可发泡的。 组合物可以包装在两室注射器中，或者存在于载体中或涂覆在基底上。
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公开(公告)号：US09138386B2
公开(公告)日：2015-09-22
申请号：US12947710
申请日：2010-11-16
申请人： Jeff MacDonald , Nancy N. Quan , Robert Hayman
发明人： Jeff MacDonald , Nancy N. Quan , Robert Hayman
CPC分类号： A61K8/22 , A61C19/066 , A61K8/19 , A61K8/60 , A61K2800/88 , A61Q11/00
摘要： A two-component whitening system has a de-sensitizing effect as well as re-mineralizing capability. The system may be an unfoamed, a foamed or a foamable composition.The system has a first component with at least one peroxide compound, at least one source of phosphate and at least one gelling agent; and a second component with at least one source of calcium, strontium and/or mixtures thereof. The second component may also contain at least one gelling agent, and the composition maybe present as a foam or is foamable.The composition may be packed in a two-compartment syringe.
摘要翻译： 双组分增白系统具有脱敏作用以及再矿化能力。 该系统可以是未发泡的，发泡的或可发泡的组合物。 该系统具有至少一种过氧化物化合物，至少一种磷酸盐源和至少一种胶凝剂的第一组分; 和具有至少一种钙，锶和/或其混合物来源的第二组分。 第二组分还可以含有至少一种胶凝剂，并且该组合物可以以泡沫形式存在或者是可发泡的。 组合物可以包装在两室注射器中。
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公开(公告)号：US20060008424A1
公开(公告)日：2006-01-12
申请号：US11173632
申请日：2005-06-30
申请人： Jeff MacDonald , Robert Hayman
发明人： Jeff MacDonald , Robert Hayman
摘要： A one-component prescription fluoride treatment composition having both fluoride efficacy and sensitivity relief is disclosed. The composition includes at least one metal fluoride and a nerve desensitizing agent such as potassium nitrate. The invention further includes a composition having at least one metal fluoride less than about 1.15% by weight of at least one metal fluoride; less than about 5 percent by weight of at least one alkali metal salt having desensitizing effect; at least one carrier; and at least one foaming agent that has thickening property. The composition may be formulated into a gel, a paste or any other convenient form, some of which contain abrasives.
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公开(公告)号：US20080112901A1
公开(公告)日：2008-05-15
申请号：US11927252
申请日：2007-10-29
申请人： Jeff MacDonald , Robert Hayman
发明人： Jeff MacDonald , Robert Hayman
摘要： A one-component prescription fluoride treatment composition having both fluoride efficacy and sensitivity relief is disclosed. The composition includes at least one metal fluoride and a nerve desensitizing agent such as potassium nitrate. The invention further includes a composition having at least one metal fluoride less than about 1.15% by weight of at least one metal fluoride; less than about 5 percent by weight of at least one alkali metal salt having desensitizing effect; at least one carrier; and at least one foaming agent that has thickening property.The composition may be formulated into a gel, a paste or any other convenient form, some of which contain abrasives.
摘要翻译： 公开了具有氟化物功效和灵敏度的单组分处方氟化物处理组合物。 该组合物包括至少一种金属氟化物和神经脱敏剂如硝酸钾。 本发明还包括一种组合物，其具有至少一种金属氟化物，其至少少于一种金属氟化物的1.15重量％ 少于约5重量％的至少一种具有脱敏作用的碱金属盐; 至少一个载体; 和至少一种具有增稠性的发泡剂。 组合物可以配制成凝胶，糊剂或任何其它方便的形式，其中一些含有研磨剂。
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公开(公告)号：US20080063612A1
公开(公告)日：2008-03-13
申请号：US11927471
申请日：2007-10-29
申请人： Jeff MacDonald , Nancy Quan , Robert Hayman
发明人： Jeff MacDonald , Nancy Quan , Robert Hayman
CPC分类号： A61K8/22 , A61C19/066 , A61K8/19 , A61K8/60 , A61K2800/88 , A61Q11/00
摘要： A two-component whitening system has a de-sensitizing effect as well as re-mineralizing capability. The system may be an unfoamed, a foamed or a foamable composition. The system has a first component with at least one peroxide compound, at least one source of phosphate and at least one gelling agent; and a second component with at least one source of calcium, strontium and/or mixtures thereof. The second component may also contain at least one gelling agent, and the composition maybe present as a foam or is foamable. The composition may be packed in a two-compartment syringe.
摘要翻译： 双组分增白系统具有脱敏作用以及再矿化能力。 该系统可以是未发泡的，发泡的或可发泡的组合物。 该系统具有至少一种过氧化物化合物，至少一种磷酸盐源和至少一种胶凝剂的第一组分; 和具有至少一种钙，锶和/或其混合物来源的第二组分。 第二组分还可以含有至少一种胶凝剂，并且该组合物可以以泡沫形式存在或者是可发泡的。 组合物可以包装在两室注射器中。
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公开(公告)号：US20060115437A1
公开(公告)日：2006-06-01
申请号：US11288504
申请日：2005-11-28
申请人： Robert Hayman , Nancy Quan , Jeff MacDonald
发明人： Robert Hayman , Nancy Quan , Jeff MacDonald
IPC分类号： A61K8/22
CPC分类号： A61K8/046 , A61K8/22 , A61K8/24 , A61K2800/88 , A61Q11/00
摘要： A whitening system has a de-sensitizing effect as well as re-mineralizing capability. The system may be a one-component or a two-component composition. The system may also be an unfoamed, a foamed or a foamable composition. For a one-component system, a sparingly soluble calcium phosphate salt may be in dry particle form with at least one gelling agent, wherein the salt is capable of sustained release of both calcium and phosphate ions into saliva upon exposure of the particle thereto and providing a hydroxyapatite remineralization. In a two component system, a first component has at least one peroxide compound, at least one source of phosphate and at least one gelling agent; and a second component has at least one source of calcium, strontium and/or mixtures thereof. The second component may also contain at least one gelling agent, and the composition maybe present as a foam or is foamable. The composition may be packed in a two-compartment syringe, or be present in a carrier or coated onto a substrate.
摘要翻译： 美白系统具有去敏化作用以及再矿化能力。 该系统可以是单组分或双组分组合物。 该系统也可以是未发泡的，发泡的或可发泡的组合物。 对于单组分体系，微溶磷酸钙盐可以具有至少一种胶凝剂的干颗粒形式，其中所述盐在颗粒暴露时能够将钙和磷酸根离子缓慢释放到唾液中并提供 羟基磷灰石再矿化。 在双组分体系中，第一组分具有至少一种过氧化物化合物，至少一种磷酸盐源和至少一种胶凝剂; 并且第二组分具有至少一种钙，锶和/或其混合物来源。 第二组分还可以含有至少一种胶凝剂，并且该组合物可以以泡沫形式存在或者是可发泡的。 组合物可以包装在两室注射器中，或者存在于载体中或涂覆在基底上。
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公开(公告)号：US08562954B2
公开(公告)日：2013-10-22
申请号：US11927252
申请日：2007-10-29
申请人： Jeff MacDonald , Robert Hayman
发明人： Jeff MacDonald , Robert Hayman
摘要： A one-component prescription fluoride treatment composition having both fluoride efficacy and sensitivity relief is disclosed. The composition includes at least one metal fluoride and a nerve desensitizing agent such as potassium nitrate. The invention further includes a composition having at least one metal fluoride less than about 1.15% by weight of at least one metal fluoride; less than about 5 percent by weight of at least one alkali metal salt having desensitizing effect; at least one carrier; and at least one foaming agent that has thickening property. The composition may be formulated into a gel, a paste or any other convenient form, some of which contain abrasives.
摘要翻译： 公开了具有氟化物功效和灵敏度的单组分处方氟化物处理组合物。 该组合物包括至少一种金属氟化物和神经脱敏剂如硝酸钾。 本发明还包括一种组合物，其具有至少一种金属氟化物，其至少少于一种金属氟化物的1.15重量％ 少于约5重量％的至少一种具有脱敏作用的碱金属盐; 至少一个载体; 和至少一种具有增稠性的发泡剂。 组合物可以配制成凝胶，糊剂或任何其它方便的形式，其中一些含有研磨剂。
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公开(公告)号：US20110059030A1
公开(公告)日：2011-03-10
申请号：US12947710
申请日：2010-11-16
申请人： Jeff MacDonald , Nancy N. Quan , Robert Hayman
发明人： Jeff MacDonald , Nancy N. Quan , Robert Hayman
CPC分类号： A61K8/22 , A61C19/066 , A61K8/19 , A61K8/60 , A61K2800/88 , A61Q11/00
摘要： A two-component whitening system has a de-sensitizing effect as well as re-mineralizing capability. The system may be an unfoamed, a foamed or a foamable composition.The system has a first component with at least one peroxide compound, at least one source of phosphate and at least one gelling agent; and a second component with at least one source of calcium, strontium and/or mixtures thereof. The second component may also contain at least one gelling agent, and the composition maybe present as a foam or is foamable.The composition may be packed in a two-compartment syringe.
摘要翻译： 双组分增白系统具有脱敏作用以及再矿化能力。 该系统可以是未发泡的，发泡的或可发泡的组合物。 该系统具有至少一种过氧化物化合物，至少一种磷酸盐源和至少一种胶凝剂的第一组分; 和具有至少一种钙，锶和/或其混合物来源的第二组分。 第二组分还可以含有至少一种胶凝剂，并且该组合物可以以泡沫形式存在或者是可发泡的。 组合物可以包装在两室注射器中。
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公开(公告)号：US20060099156A1
公开(公告)日：2006-05-11
申请号：US11271412
申请日：2005-11-09
申请人： Jeff MacDonald , Nancy Quan , Robert Hayman
发明人： Jeff MacDonald , Nancy Quan , Robert Hayman
IPC分类号： A61K8/22
CPC分类号： A61K8/22 , A61C19/066 , A61K8/19 , A61K8/60 , A61K2800/88 , A61Q11/00
摘要： A two-component whitening system has a de-sensitizing effect as well as re-mineralizing capability. The system may be an unfoamed, a foamed or a foamable composition. The system has a first component with at least one peroxide compound, at least one source of phosphate and at least one gelling agent; and a second component with at least one source of calcium, strontium and/or mixtures thereof. The second component may also contain at least one gelling agent, and the composition maybe present as a foam or is foamable. The composition may be packed in a two-compartment syringe.
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