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    Sustained release intraocular drug delivery systems
    2.
    发明申请
    Sustained release intraocular drug delivery systems 审中-公开
    持续释放眼内药物递送系统

    公开(公告)号：US20060182783A1

    公开(公告)日：2006-08-17

    申请号：US11370301

    申请日：2006-03-08

    申请人： Patrick Hughes ,  Gerald Devries ,  Jeffrey Edelman ,  Wendy Blanda ,  Lon Spada ,  Robert Lyons

    发明人： Patrick Hughes ,  Gerald Devries ,  Jeffrey Edelman ,  Wendy Blanda ,  Lon Spada ,  Robert Lyons

    IPC分类号： A61K48/00 ,  A61F2/00

    CPC分类号： A61K9/0051 ,  A61F9/0008 ,  A61F9/0017 ,  A61K9/1647 ,  A61K31/724 ,  A61K47/34 ,  A61K47/40 ,  A61K48/0041

    摘要： Biocompatible intraocular drug delivery systems include a anti-angiogenic macromolecular therapeutic agent and a polymeric component in the form of an implant, a microparticle, a plurality of implants or microparticles, and combinations thereof. The therapeutic agent is released in a biologically active form, for example, the therapeutic agent may retain its three dimensional structure when released into an eye of a patient, or the therapeutic agent may have an altered three dimensional structure but retain its therapeutic activity. The therapeutic agent contains a component selected from the group consisting of anti-angiogenesis peptides and nucleic acid agents. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy among others.

    摘要翻译： 生物相容性眼内药物递送系统包括抗血管生成大分子治疗剂和植入物，微粒，多种植入物或微粒形式的聚合物组分及其组合。 治疗剂以生物活性形式释放，例如，当释放到患者的眼睛中时，治疗剂可以保持其三维结构，或者治疗剂可以具有改变的三维结构，但保持其治疗活性。 治疗剂含有选自抗血管生成肽和核酸试剂的组分。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变等。

    Macromolecule-containing sustained release intraocular implants and related methods
    3.
    发明申请
    Macromolecule-containing sustained release intraocular implants and related methods 审中-公开
    含大分子的持续释放眼内植入物及相关方法

    公开(公告)号：US20050281861A1

    公开(公告)日：2005-12-22

    申请号：US11116698

    申请日：2005-04-27

    申请人： Patrick Hughes ,  Tom Malone ,  Gerald Devries ,  Jeffrey Edelman ,  Wendy Blanda ,  Lon Spada ,  Peter Baciu ,  Scott Whitcup

    发明人： Patrick Hughes ,  Tom Malone ,  Gerald Devries ,  Jeffrey Edelman ,  Wendy Blanda ,  Lon Spada ,  Peter Baciu ,  Scott Whitcup

    IPC分类号： A61F2/00 ,  A61F9/00 ,  A61K9/00 ,  A61K9/16 ,  A61K31/724 ,  A61K39/395 ,  A61K47/34 ,  A61K47/40 ,  A61K47/48 ,  A61K48/00

    CPC分类号： A61K9/0051 ,  A61F9/0008 ,  A61F9/0017 ,  A61K9/1647 ,  A61K31/724 ,  A61K47/34 ,  A61K47/40

    摘要： Biocompatible intraocular drug delivery systems include a non-neurotoxic macromolecule therapeutic agent and a polymeric component in the form of an implant, a microparticle, a plurality of implants or microparticles, and combinations thereof. The macromolecule therapeutic agent is released in a biologically active form, for example, the therapeutic agent may retain its three dimensional structure when released into an eye of a patient, or the therapeutic agent may have an altered three dimensional structure but retain its therapeutic activity. The therapeutic agent may be selected from the group consisting of anti-angiogenesis agents, ocular hemorrhage treatment agents, non-steroidal anti-inflammatory agents, growth factor inhibitors (such as VEGF inhibitors), growth factors, cytokines, antibodies, oligonucleotide aptamers, siRNA molecules and antibiotics. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy among others.

    摘要翻译： 生物相容性眼内药物递送系统包括非神经毒性大分子治疗剂和植入物，微粒，多种植入物或微粒形式的聚合物组分及其组合。 大分子治疗剂以生物活性形式释放，例如，当释放到患者的眼睛中时，治疗剂可保留其三维结构，或者治疗剂可具有改变的三维结构，但保持其治疗活性。 治疗剂可以选自抗血管生成剂，眼出血治疗剂，非甾体抗炎剂，生长因子抑制剂（例如VEGF抑制剂），生长因子，细胞因子，抗体，寡核苷酸适体，siRNA 分子和抗生素。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变等。

    Anti-angiogenic sustained release intraocular implants and related methods
    4.
    发明申请
    Anti-angiogenic sustained release intraocular implants and related methods 审中-公开
    抗血管生成持续释放眼内植入物及相关方法

    公开(公告)号：US20070059336A1

    公开(公告)日：2007-03-15

    申请号：US11364687

    申请日：2006-02-27

    申请人： Patrick Hughes ,  Thomas Malone ,  Gerald De Vries ,  Jeffrey Edelman ,  Wendy Blanda ,  Lon Spada ,  Peter Baciu ,  Scott Whitcup

    发明人： Patrick Hughes ,  Thomas Malone ,  Gerald De Vries ,  Jeffrey Edelman ,  Wendy Blanda ,  Lon Spada ,  Peter Baciu ,  Scott Whitcup

    IPC分类号： A61K38/18 ,  A61K39/395

    CPC分类号： A61K48/0041 ,  A61K9/0051

    摘要： Biocompatible intraocular drug delivery systems include a anti-angiogenic therapeutic agent and a polymeric component in the form of an implant, a microparticle, a plurality of implants or microparticles, and combinations thereof. The therapeutic agent is released in a biologically active form, for example, the therapeutic agent may retain its three dimensional structure when released into an eye of a patient, or the therapeutic agent may have an altered three dimensional structure but retain its therapeutic activity. The therapeutic agent may be selected from the group consisting of anti-angiogenesis peptides, hormones and nucleic acid agents. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy among others.

    摘要翻译： 生物相容性眼内药物递送系统包括抗血管生成治疗剂和植入物，微粒，多种植入物或微粒形式的聚合物组分及其组合。 治疗剂以生物活性形式释放，例如，当释放到患者的眼睛中时，治疗剂可以保持其三维结构，或者治疗剂可以具有改变的三维结构，但保持其治疗活性。 治疗剂可以选自抗血管生成肽，激素和核酸试剂。 植入物可以置于眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变等。

    Memantine intravitreal implants
    7.
    发明申请
    Memantine intravitreal implants 审中-公开
    美金刚玻璃体内植入物

    公开(公告)号：US20050244473A1

    公开(公告)日：2005-11-03

    申请号：US11117879

    申请日：2005-04-29

    申请人： Patrick Hughes ,  Lon Spada ,  Hiroshi Sugimoto ,  Wendy Blanda ,  James Chang

    发明人： Patrick Hughes ,  Lon Spada ,  Hiroshi Sugimoto ,  Wendy Blanda ,  James Chang

    IPC分类号： A61K9/00 ,  A61K31/13 ,  A61F2/00

    CPC分类号： A61K9/0051

    摘要： Biocompatible intraocular implants include an anti-excitotoxic agent and a biodegradable polymer that is effective to facilitate release of the anti-excitotoxic agent into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy.

    摘要翻译： 生物相容性眼内植入物包括抗兴奋性毒性剂和可生物降解的聚合物，其有效促进抗兴奋性毒性剂长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变。

    Dispensing tip
    9.
    发明申请
    Dispensing tip 有权
    点胶尖

    公开(公告)号：US20050274744A1

    公开(公告)日：2005-12-15

    申请号：US10865055

    申请日：2004-06-10

    申请人： Lon Spada ,  Paul Butorac

    发明人： Lon Spada ,  Paul Butorac

    IPC分类号： A61F9/00 ,  B05C5/02 ,  B65D47/18 ,  A61M29/00

    CPC分类号： A61F9/0026 ,  B65D47/18

    摘要： A dispensing tip includes a body suitable for attachment to a dispensing bottle along with a nozzle having a lumen therethrough for flow of liquid formulation and an egress orifice which is in fluid communication with the lumen for the formation of droplets. A concave arcuate surface of revolution about the egress orifice is provided and depending therefrom for enhancing droplet separation from the egress orifice which in turn insures uniform droplet formation and dispensement.

    摘要翻译： 分配尖端包括适于附接到分配瓶的主体以及具有用于液体制剂流动的通孔的喷嘴以及与内腔流体连通以形成液滴的出口孔。 提供了围绕出口孔的凹曲面的旋转表面，并且由此排出用于增强与出口孔的液滴分离，从而确保均匀的液滴形成和分配。

    Autoclaveable small-volume dropper bottle
    10.
    发明申请
    Autoclaveable small-volume dropper bottle 有权
    高压灭菌小容量滴瓶

    公开(公告)号：US20060111680A1

    公开(公告)日：2006-05-25

    申请号：US10997266

    申请日：2004-11-23

    申请人： Lon Spada ,  Paul Butorac ,  Scott Gerondale

    发明人： Lon Spada ,  Paul Butorac ,  Scott Gerondale

    IPC分类号： A61M35/00 ,  B65D47/18

    CPC分类号： A61F9/0008 ,  B65D1/32 ,  B65D47/18

    摘要： A terminally sterilizable container includes a polypropylene bottle having a body with a manually squeezable sidewall and a thickness preventing water loss. The bottle body includes shoulders for providing autoclave produced pressure distribution and deformation resistance along with an elongated tips outfitted to a neck of the body and having a lumen therethrough with a drop dispensing orifice. A cap enclosed the elongated tip and includes enclosed with a nub for sealing the orifice to prevent autoclave produced pressure leaks.

    摘要翻译： 末端可灭菌的容器包括具有手动可挤压侧壁的主体和防止水分损失的厚度的聚丙烯瓶。 瓶体包括用于提供高压釜产生的压力分布和变形阻力的肩部以及装配到主体的颈部并且具有通过其的腔的液滴分配孔的细长尖端。 盖子包住细长的尖端，并且包括用小孔封闭以密封孔口，以防止高压釜产生的压力泄漏。