公开(公告)号：US12121630B2

公开(公告)日：2024-10-22

申请号：US17271817

申请日：2019-09-03

Applicant: Massachusetts Eye and Ear Infirmary

Inventor： Roholah Sharifi ,  Miguel Gonzalez Andrades ,  James Chodosh

IPC: A61L27/50 ,  A61L24/00 ,  A61L24/10 ,  A61L27/22 ,  B29C35/08 ,  B29L31/00

CPC classification number: A61L27/50 ,  A61L24/001 ,  A61L24/104 ,  A61L27/222 ,  A61L2400/06 ,  A61L2430/16 ,  B29C35/0805 ,  B29K2089/00 ,  B29K2907/00 ,  B29L2031/753

Abstract: The present invention discloses compositions and methods for repair and reconstruction of defects and injuries to soft tissues. Some aspects of the disclosure provide methods for corneal reconstruction by applying an engineered bioadhesive, glycidyl methacrylate-substituted gelatin and a visible light activated photoinitiator in presence of visible light to the corneal defect.

公开(公告)号：US20240293224A1

公开(公告)日：2024-09-05

申请号：US18662925

申请日：2024-05-13

Applicant: Gholam Peyman

Inventor： Gholam Peyman ,  Lisa Brothers Arbisser

IPC: A61F2/16 ,  A61F2/00 ,  A61L27/16 ,  A61L27/50 ,  B33Y40/20 ,  B33Y80/00

CPC classification number: A61F2/1648 ,  A61L27/16 ,  A61L27/50 ,  A61F2002/0081 ,  A61F2002/1689 ,  A61F2002/16965 ,  A61F2240/001 ,  A61F2250/0091 ,  A61L2400/12 ,  A61L2430/16 ,  B33Y40/20 ,  B33Y80/00

Abstract: An apparatus has a central lens body for providing vision correction for a patient. The lens body has a central aperture and is configured as one of: a diffractive lens or a refractive lens. The lens body has at least one haptic extending from the lens body, and the central aperture has a form of a circular hole extending fully through the lens body when the apparatus is implanted in the eye. The lens body is formed from a substantially transparent material and the central aperture includes a darkened perimeter. The darkened perimeter of the central aperture includes a darkened internal wall extending through the lens body from an anterior surface to a posterior surface of the lens body.

公开(公告)号：US20240277524A1

公开(公告)日：2024-08-22

申请号：US18651341

申请日：2024-04-30

Applicant: Iantrek, Inc.

Inventor： Tsontcho Ianchulev

IPC: A61F9/007 ,  A61L27/36

CPC classification number: A61F9/00781 ,  A61F9/00763 ,  A61L27/3604 ,  A61L27/3641 ,  A61L2430/16

Abstract: A system for preparation of an implant and ab interno insertion of the implant into an eye including a handle having one or more actuators and an elongated shaft having an outer sheath and an elongate member positioned within a lumen of the tubular outer sheath. The system includes a recess sized for holding a patch of material fixed relative to the handle and a cutting member movable relative to the handle and to the recess. The cutting member cuts the patch of material into an implant as the cutting member moves towards a cutting configuration. The implant, once cut, is axially aligned with the lumen of the tubular outer sheath. The inner elongate member is movable relative to the tubular outer sheath to advance the implant into a deployment position in the lumen of the tubular outer sheath for delivery into the eye. Related devices and methods are provided.

公开(公告)号：US20240269347A1

公开(公告)日：2024-08-15

申请号：US18471748

申请日：2023-09-21

Applicant: The Brigham and Women's Hospital, Inc.

Inventor： Ali Khademhosseini ,  Nasim Annabi ,  Reza Dana ,  Ahmad Kheirkhah

IPC: A61L27/38 ,  A61L27/22 ,  A61L27/52 ,  A61P27/02

CPC classification number: A61L27/3804 ,  A61L27/222 ,  A61L27/3839 ,  A61L27/52 ,  A61P27/02 ,  A61L2430/16

Abstract: The present disclosure provides compositions and methods for repair and reconstruction of defects and injuries to the cornea. For example, the present disclosure provides a composition for corneal reconstruction including a methacryloyl-substituted gelatin, a visible light-activated photoinitiator, and a pharmaceutically acceptable carrier. In another example, the present disclosure provides a method for corneal reconstruction including the steps of: applying a composition and exposing the composition to visible light.

公开(公告)号：US20240252723A1

公开(公告)日：2024-08-01

申请号：US18422182

申请日：2024-01-25

Applicant: Alcon Inc.

Inventor： Steven T. Charles

IPC: A61L27/38 ,  A61K9/00 ,  A61K9/06 ,  A61K35/30 ,  A61K47/34 ,  A61L27/18 ,  A61L27/36 ,  A61L27/44 ,  A61L27/58

CPC classification number: A61L27/3804 ,  A61K9/0051 ,  A61K9/06 ,  A61K35/30 ,  A61K47/34 ,  A61L27/18 ,  A61L27/3604 ,  A61L27/44 ,  A61L27/58 ,  A61L2430/16

Abstract: Described herein is a method for replacing retinal tissue with retinal cell-embedded biodegradable matrix ribbons. The biodegradable matrix ribbons can be provided as a sheet and subsequently cut into ribbons. Alternatively, the biodegradable matrix ribbons can be constructed in ribbon form. The thin ribbons can then be implanted into a patient's eye through small scleral and/or retinal incisions. Once inside the ocular space, the ribbons can be positioned at a target retinal space in a confluent fashion in order to provide an area of biodegradable matrix having retinal cells embedded within and on outer surfaces thereof.

公开(公告)号：US12049642B2

公开(公告)日：2024-07-30

申请号：US15666518

申请日：2017-08-01

Applicant: Astellas Institute for Regenerative Medicine

Inventor： Kathryn L. McCabe ,  Shi-Jiang Lu ,  Robert P. Lanza

IPC: C12N5/071 ,  A61K9/00 ,  A61K35/30 ,  A61K45/06 ,  A61L27/38 ,  C12N5/07 ,  C12N5/074 ,  C12N5/079 ,  C12N5/0797 ,  C12N5/16

CPC classification number: C12N5/0621 ,  A61K9/0048 ,  A61K35/30 ,  A61K45/06 ,  A61L27/3808 ,  A61L27/3839 ,  A61L27/3895 ,  C12N5/0623 ,  A61L2430/16 ,  C12N2500/60 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/40 ,  C12N2501/415 ,  C12N2501/727 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/08 ,  C12N2506/45 ,  C12N2533/50

Abstract: This disclosure generally relates to cell-based therapies for treatment of visual disorders, including disorders of the cornea. Methods are exemplified for directed differentiation of corneal cells from stem cells. Compositions of corneal endothelial cells and uses thereof are also provided. Exemplary compositions exhibit improved cell density and/or more “youthful” gene expression relative to cells obtained from donated tissue.

公开(公告)号：US20240207042A1

公开(公告)日：2024-06-27

申请号：US18682924

申请日：2022-08-07

Applicant: PRECISE BIO 3D LTD

Inventor： Yossi BOUKOBZA ,  Amos EITAN ,  Ariel EISENBACH ,  Eliahu ELIACHAR ,  Michal MARCUS ,  Gilad RABINA ,  Lior ROSENBERG BELMAKER ,  Amit SEGAL ,  Dorin SADE YAZDI

IPC: A61F2/14 ,  A61F9/00 ,  A61L27/36

CPC classification number: A61F2/148 ,  A61F2/142 ,  A61F9/0017 ,  A61L27/3604 ,  A61L27/3675 ,  A61L2430/16

Abstract: The present invention provides an insertion tool for inserting an implant, said implant having an implant lower side and an implant upper side, said implant upper side comprising cells, said insertion tool comprising: an implant carrier configured to hold said implant; and a body having at least two configurations, a first body configuration with said implant carrier at least partially contained within said body and said implant held by said implant carrier and a second body configuration with said implant carrier outside said body; said implant carrier is configured to maintain a position of the implant and a shape of the implant and functionality of said cells during such time as the implant carrier is contained by said body, and during an implantation procedure.

公开(公告)号：US11992582B2

公开(公告)日：2024-05-28

申请号：US16622476

申请日：2018-06-15

Applicant: ACCOMMO AG

Inventor： Eduard Anton Haefliger

IPC: A61L27/54 ,  A61F2/16 ,  A61L27/20 ,  A61L27/38 ,  A61L27/22 ,  A61L27/36 ,  C08L5/08

CPC classification number: A61L27/54 ,  A61F2/1613 ,  A61L27/20 ,  A61L27/3813 ,  A61L27/3869 ,  A61F2/16 ,  A61L27/227 ,  A61L27/3666 ,  A61L2300/414 ,  A61L2300/428 ,  A61L2300/432 ,  A61L2430/16 ,  C08L5/08

Abstract: The invention concerns an intraocular lens implant for placement into an intracapsular space of a lens capsule of an eye and a composition, kit and methods related to the lens implant. The lens implant is designed for a placement into a posterior portion of the intracapsular space after removal of a native lens body and has a convex posterior surface. The lens implant is formed of one part and is manufactured from a suitable transparent non-structural cellular material. This keeps an anterior portion of the intracapsular space free of the implant which is dimensioned to comprise at most 40% of a volume of the native lens body.

公开(公告)号：US20240164943A1

公开(公告)日：2024-05-23

申请号：US18430141

申请日：2024-02-01

Applicant: Iantrek, Inc.

Inventor： Tsontcho Ianchulev

IPC: A61F9/007 ,  A61L27/36

CPC classification number: A61F9/00781 ,  A61F9/00763 ,  A61L27/3604 ,  A61L27/3641 ,  A61L2430/16

Abstract: A system for preparation of an implant and ab interno insertion of the implant into an eye including a handle having one or more actuators and an elongated shaft having an outer sheath and an elongate member positioned within a lumen of the tubular outer sheath. The system includes a recess sized for holding a patch of material fixed relative to the handle and a cutting member movable relative to the handle and to the recess. The cutting member cuts the patch of material into an implant as the cutting member moves towards a cutting configuration. The implant, once cut, is axially aligned with the lumen of the tubular outer sheath. The inner elongate member is movable relative to the tubular outer sheath to advance the implant into a deployment position in the lumen of the tubular outer sheath for delivery into the eye. Related devices and methods are provided.

公开(公告)号：US20240082053A1

公开(公告)日：2024-03-14

申请号：US17769626

申请日：2020-10-19

Applicant: Carnegie Mellon University

Inventor： Adam Walter Feinberg ,  Rachelle Simko

IPC: A61F9/00 ,  A61K35/30 ,  A61L27/18 ,  A61L27/34 ,  A61L27/36 ,  A61L27/38 ,  A61L27/50 ,  C12N5/079

CPC classification number: A61F9/0017 ,  A61K35/30 ,  A61L27/18 ,  A61L27/34 ,  A61L27/3633 ,  A61L27/3808 ,  A61L27/507 ,  C12N5/0621 ,  A61F2250/0067 ,  A61L2300/414 ,  A61L2300/62 ,  A61L2300/64 ,  A61L2430/16 ,  C12N2533/90

Abstract: A process for micro-tissue encapsulation of cells includes coating a tissue scaffold stamp with an extracellular matrix compound. The process includes depositing the tissue scaffold stamp onto a thermoresponsive substrate and seeding the tissue scaffold stamp with a cell culture. A cell culture forms a cell patch that is attached to the extracellular matrix compound. A monolayer on the tissue scaffold stamp for which borders of the monolayer maintain expressions for cell-cell junctions, wherein the cell-cell junctions of the monolayer are configured to express tension forces. The process includes removing the thermoresponsive substrate. The process includes folding the micro-tissue structure by suspending the micro-tissue in the solvent. The folded micro-tissue structure is collected from the solvent and administered to an organism.