公开(公告)号：US20080305493A1

公开(公告)日：2008-12-11

申请号：US10591049

申请日：2005-03-08

申请人： Jeffrey W. Strovel ,  Colyn B. Cain ,  Stephen K. Horrigan ,  Meena Augustus

发明人： Jeffrey W. Strovel ,  Colyn B. Cain ,  Stephen K. Horrigan ,  Meena Augustus

IPC分类号： G01N33/53 ,  C12Q1/68 ,  C12Q1/02 ,  C12N5/06 ,  G01N33/566

CPC分类号： G01N33/5011 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  G01N2800/52

摘要： Methods for identifying antineoplastic agents by using their ability to modify expression of specific genes or the biological activity of polypeptides encoded by such genes, wherein said genes are located in specific chromosomal regions, called amplicons, or regions of interest, and the presence of such amplified regions within a cancerous cell, are disclosed. Also described are methods for diagnosing cancerous, or potentially cancerous, conditions using these methods. Also encompassed are methods involving determining the modulated expression of the genes in these regions of interest (ROIs), or amplicons, as pharmacodynamic/pharmacogenetic/surrogate markers and/or for patient profiling prior to accrual for clinical trials/treatments based on the identification of these genes as validated gene/drug targets in various cancer tissue types.

摘要翻译： 通过使用其改变特定基因表达的能力或由这些基因编码的多肽的生物活性鉴定抗肿瘤药物的方法，其中所述基因位于特定染色体区域，称为扩增子或感兴趣区域，并且存在扩增的 公开了癌细胞内的区域。 还描述了使用这些方法诊断癌症或潜在癌症病症的方法。 还包括涉及确定在这些感兴趣区域（ROI）或扩增子中的基因的调节表达作为药效学/药物遗传学/替代标记物和/或用于基于鉴定的临床试验/治疗应用之前的患者分析的方法 这些基因作为各种癌组织类型中经验证的基因/药物靶标。