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    COMPOSITION INCLUDING 3-BROMO-4,5-DIHYDROXYBENZALDEHYDE COMPOUND AS EFFECTIVE COMPONENT FOR PROTECTING AND TREATING SKIN CELL AGANIST ULTRAVIOLET
    1.
    发明申请
    COMPOSITION INCLUDING 3-BROMO-4,5-DIHYDROXYBENZALDEHYDE COMPOUND AS EFFECTIVE COMPONENT FOR PROTECTING AND TREATING SKIN CELL AGANIST ULTRAVIOLET 审中-公开
    包含3-BROMO-4,5-二羟基苯甲醚化合物的组合物作为有效成分，用于保护和处理皮肤细胞分泌物超紫外线

    公开(公告)号：US20140004062A1

    公开(公告)日：2014-01-02

    申请号：US13846191

    申请日：2013-03-18

    申请人： Jeju National University Industry-Academic Cooperation Foundation

    发明人： Jin-Won Hyun ,  Hee-Kyoung Kang ,  Nam-Ho Lee ,  Sung-Wook Chae

    IPC分类号： A61K31/11 ,  A61Q17/04

    CPC分类号： A61K31/11 ,  A61K8/347 ,  A61Q17/04

    摘要： There is provided a composition including a 3-bromo-4,5-dihydroxybenzaldehyde (BDB) for protecting human skin keratinocyte from ultraviolet, in which the BDB has a photo-protective effect against cell damage caused by ultraviolet in human HaCaT skin keratinocyte, activity of removing a free radical, and ultraviolet absorption activity, and inhibits formations of lipid peroxidation and protein carbonyl, inhibits DNA damage, protects a cell, and thereby exhibits cell protective activity. Thus, the BDB decreases apoptosis induced by ultraviolet, and then protect a cell to recover cell viability.

    摘要翻译： 提供了包含用于保护人皮肤角质形成细胞免受紫外线的3-溴-4,5-二羟基苯甲醛（BDB）的组合物，其中BDB具有对人HaCaT皮肤角质形成细胞中的紫外线引起的细胞损伤的光保护作用，活性 去除自由基和紫外线吸收活性，抑制脂质过氧化和蛋白质羰基的形成，抑制DNA损伤，保护细胞，从而表现出细胞保护活性。 因此，BDB降低由紫外线引起的凋亡，然后保护细胞以恢复细胞活力。