公开(公告)号：US20060039908A1

公开(公告)日：2006-02-23

申请号：US11147942

申请日：2005-06-07

申请人： Jennie Mather ,  Penelope Roberts ,  Ronghao Li

发明人： Jennie Mather ,  Penelope Roberts ,  Ronghao Li

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2881 ,  A61K39/39533 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/77 ,  Y10S530/808 ,  Y10S530/809 ,  A61K2300/00

摘要： The invention provides further characterization of the disease and cancer-associated antigen, transferrin receptor. The invention also provides a novel family of antibodies that bind to the transferrin receptor, methods of diagnosing and treating various human cancers and diseases that express transferrin receptor.

公开(公告)号：US20060177453A1

公开(公告)日：2006-08-10

申请号：US11349327

申请日：2006-02-06

申请人： Jennie Mather ,  Penelope Roberts

发明人： Jennie Mather ,  Penelope Roberts

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C07K16/30 ,  C12N5/06

CPC分类号： C07K16/30 ,  A61K47/6825 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6897 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2866 ,  C07K2317/73 ,  C07K2317/77

摘要： Provided herein is disclosure about the development and characterization of an antibody that binds to antigen EphA2 which is present on a variety of human cancers from breast, lung, prostate, and colons. Methods of diagnosing and treating various cancers by using such antibodies directed against this antigen are also disclosed.

公开(公告)号：US20060171951A1

公开(公告)日：2006-08-03

申请号：US11346812

申请日：2006-02-03

申请人： Jennie Mather ,  Penelope Roberts

发明人： Jennie Mather ,  Penelope Roberts

IPC分类号： C07K16/30 ,  G01N33/574 ,  A61K39/395

CPC分类号： G01N33/57492 ,  A61K2039/505 ,  C07K16/248 ,  C07K16/2866 ,  C07K16/30 ,  C07K2317/73 ,  G01N33/574 ,  G01N2333/715

摘要： The invention provides characterization of the disease and cancer-associated antigen, OSM-R.beta. The invention also provides modulators of OSM-R.beta, including a family of monoclonal antibodies that bind to antigen OSM-R.beta, and methods of diagnosing and treating various human cancers and diseases associated with OSM-R.beta.

公开(公告)号：US20060172349A1

公开(公告)日：2006-08-03

申请号：US11344814

申请日：2006-01-31

申请人： Jennie Mather ,  Penelope Roberts

发明人： Jennie Mather ,  Penelope Roberts

IPC分类号： G01N33/574 ,  C07K16/30

CPC分类号： C07K16/3023 ,  A61K47/6825 ,  A61K47/6857 ,  A61K2039/505 ,  C07K2317/73 ,  C07K2317/77 ,  G01N33/5091 ,  G01N33/574 ,  G01N33/57492

摘要： The invention provides the identification and characterization of disease and cancer-associated antigen, LUCA2. The invention also provides a family of monoclonal antibodies that bind to antigen LUCA2, methods of diagnosing and treating various human cancers and diseases that express LUCA2.

摘要翻译： 本发明提供疾病和癌症相关抗原LUCA2的鉴定和表征。 本发明还提供了与抗原LUCA2结合的单克隆抗体家族，诊断和治疗表达LUCA2的各种人类癌症和疾病的方法。

公开(公告)号：US20060171952A1

公开(公告)日：2006-08-03

申请号：US11347057

申请日：2006-02-02

申请人： Jennie Mather ,  Penelope Roberts

发明人： Jennie Mather ,  Penelope Roberts

IPC分类号： A61K39/395 ,  C07K16/30

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/73 ,  C07K2317/77

摘要： The invention provides the identification and characterization of disease and cancer-associated antigen, JAM-3. The invention also provides a family of monoclonal antibodies that bind to antigen JAM-3, methods of diagnosing and treating various human cancers and diseases that express JAM-3.

摘要翻译： 本发明提供疾病和癌症相关抗原JAM-3的鉴定和表征。 本发明还提供了结合抗原JAM-3的单克隆抗体家族，诊断和治疗表达JAM-3的各种人类癌症和疾病的方法。

公开(公告)号：US20080175870A1

公开(公告)日：2008-07-24

申请号：US12018126

申请日：2008-01-22

申请人： Jennie P. Mather ,  Penelope Roberts

发明人： Jennie P. Mather ,  Penelope Roberts

IPC分类号： A61K39/00 ,  C12N5/06 ,  A61K35/00 ,  G01N33/574 ,  A61P37/00

CPC分类号： C12N5/0695

摘要： This invention discloses isolated populations of human cancer stem cells. Methods for characterizing, isolating and culturing human cancer stem cells are also disclosed. Uses for human cancer stem cells are provided.

摘要翻译： 本发明公开了人类癌症干细胞的分离群体。 还公开了表征，分离和培养人类癌症干细胞的方法。 提供用于人类癌症干细胞的用途。