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公开(公告)号：US20070077623A1
公开(公告)日：2007-04-05
申请号：US11518609
申请日：2006-09-07
申请人： Avi Ashkenazi , David Bolstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Jennie Mather , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , David Bolstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Jennie Mather , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号： C12P21/06 , C07H21/04 , C12N9/00 , C07K14/705 , C07K16/18
CPC分类号： C07K14/47 , C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060177453A1
公开(公告)日：2006-08-10
申请号：US11349327
申请日：2006-02-06
申请人： Jennie Mather , Penelope Roberts
发明人： Jennie Mather , Penelope Roberts
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/30 , C12N5/06
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2866 , C07K2317/73 , C07K2317/77
摘要： Provided herein is disclosure about the development and characterization of an antibody that binds to antigen EphA2 which is present on a variety of human cancers from breast, lung, prostate, and colons. Methods of diagnosing and treating various cancers by using such antibodies directed against this antigen are also disclosed.
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公开(公告)号：US20060172350A1
公开(公告)日：2006-08-03
申请号：US11346779
申请日：2006-02-02
申请人： Jennie Mather , Deryk Loo
发明人： Jennie Mather , Deryk Loo
IPC分类号： G01N33/574 , C07K16/30
CPC分类号： G01N33/57484 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K16/40 , C07K2317/73 , C07K2317/77 , G01N33/574 , G01N33/57492 , G01N2333/705 , G01N2333/96486
摘要： The invention provides the identification and characterization of a disease and cancer-associated antigen, KID24. The invention also provides modulators of KID24, including a family of monoclonal antibodies that bind to antigen KID24, and methods of diagnosing and treating various human cancers and diseases associated with KID24.
摘要翻译： 本发明提供了疾病和癌症相关抗原KID24的鉴定和表征。 本发明还提供KID24的调节剂，包括与抗原KID24结合的单克隆抗体家族，以及诊断和治疗与KID24相关的各种人类癌症和疾病的方法。
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公开(公告)号：US20060275864A9
公开(公告)日：2006-12-07
申请号：US10970823
申请日：2004-10-20
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Jennie Mather , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Jennie Mather , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060246540A1
公开(公告)日：2006-11-02
申请号：US11240891
申请日：2005-09-29
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Ivar Kljavin , Jennie Mather , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , Colin Watanabe , P. Williams , William Wood , Zemin Zhang
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Ivar Kljavin , Jennie Mather , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , Colin Watanabe , P. Williams , William Wood , Zemin Zhang
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060172349A1
公开(公告)日：2006-08-03
申请号：US11344814
申请日：2006-01-31
申请人： Jennie Mather , Penelope Roberts
发明人： Jennie Mather , Penelope Roberts
IPC分类号： G01N33/574 , C07K16/30
CPC分类号： C07K16/3023 , A61K47/6825 , A61K47/6857 , A61K2039/505 , C07K2317/73 , C07K2317/77 , G01N33/5091 , G01N33/574 , G01N33/57492
摘要： The invention provides the identification and characterization of disease and cancer-associated antigen, LUCA2. The invention also provides a family of monoclonal antibodies that bind to antigen LUCA2, methods of diagnosing and treating various human cancers and diseases that express LUCA2.
摘要翻译： 本发明提供疾病和癌症相关抗原LUCA2的鉴定和表征。 本发明还提供了与抗原LUCA2结合的单克隆抗体家族，诊断和治疗表达LUCA2的各种人类癌症和疾病的方法。
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公开(公告)号：US20060171952A1
公开(公告)日：2006-08-03
申请号：US11347057
申请日：2006-02-02
申请人： Jennie Mather , Penelope Roberts
发明人： Jennie Mather , Penelope Roberts
IPC分类号： A61K39/395 , C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2803 , C07K2317/73 , C07K2317/77
摘要： The invention provides the identification and characterization of disease and cancer-associated antigen, JAM-3. The invention also provides a family of monoclonal antibodies that bind to antigen JAM-3, methods of diagnosing and treating various human cancers and diseases that express JAM-3.
摘要翻译： 本发明提供疾病和癌症相关抗原JAM-3的鉴定和表征。 本发明还提供了结合抗原JAM-3的单克隆抗体家族，诊断和治疗表达JAM-3的各种人类癌症和疾病的方法。
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公开(公告)号：US20060039908A1
公开(公告)日：2006-02-23
申请号：US11147942
申请日：2005-06-07
申请人： Jennie Mather , Penelope Roberts , Ronghao Li
发明人： Jennie Mather , Penelope Roberts , Ronghao Li
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2881 , A61K39/39533 , A61K2039/505 , C07K16/2863 , C07K2317/77 , Y10S530/808 , Y10S530/809 , A61K2300/00
摘要： The invention provides further characterization of the disease and cancer-associated antigen, transferrin receptor. The invention also provides a novel family of antibodies that bind to the transferrin receptor, methods of diagnosing and treating various human cancers and diseases that express transferrin receptor.
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公开(公告)号：US20050214904A1
公开(公告)日：2005-09-29
申请号：US10970823
申请日：2004-10-20
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Jennie Mather , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Jennie Mather , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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10.发明申请Antibodies that bind to cancer-associated antigen CD46 and methods of use thereof 有权结合癌相关抗原CD46的抗体及其使用方法公开(公告)号：US20070128202A1
公开(公告)日：2007-06-07
申请号：US11524344
申请日：2006-09-19
申请人： Jennie Mather
发明人： Jennie Mather
IPC分类号： G01N33/574 , C07H21/04 , C12P21/06 , A61K39/395 , C07K16/30 , C07K16/46
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2896 , C07K2317/73 , C07K2317/77
摘要： Provided herein is disclosure about the development and characterization of an antibody (mPA7) which binds to antigen CD46 which is present on a variety of human cancers from ovary, breast, lung, prostate, colon, kidney, and pancreas. Methods of diagnosing and treating various cancers by using antibodies such as mPA7 directed against this antigen are also disclosed.
摘要翻译： 本文提供了关于与存在于来自卵巢，乳腺，肺，前列腺，结肠，肾和胰腺的各种人类癌症的抗原CD46结合的抗体（mPA7）的开发和表征的公开。 还公开了通过使用针对该抗原的抗体如mPA7诊断和治疗各种癌症的方法。
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