公开(公告)号：US07413866B2

公开(公告)日：2008-08-19

申请号：US10452015

申请日：2003-05-30

申请人： Jennifer M. Burns ,  Zhenhua Miao ,  Zheng Wei ,  Maureen C. Howard ,  Brett A. Premack ,  Thomas J. Schall

发明人： Jennifer M. Burns ,  Zhenhua Miao ,  Zheng Wei ,  Maureen C. Howard ,  Brett A. Premack ,  Thomas J. Schall

IPC分类号： G01N33/50 ,  C07K14/00

CPC分类号： G01N33/6863 ,  G01N2500/10

摘要： The present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of a chemokine receptor but not a second topology of the receptor. Such agents are useful as therapeutics for diseases or conditions associated with a particular chemokine receptor topology. Moreover, the agents are useful for detecting a particular topology of a chemokine receptor, thereby diagnosing disease or predisposition for a disease. In addition, the agents are useful for identifying and isolating cells that express a particular topology of a chemokine receptor.

摘要翻译： 本发明提供用于鉴定特异性结合和/或调节趋化因子受体的一个拓扑但不是受体的第二拓扑结构的试剂的方法。 这样的试剂可用作与特定趋化因子受体拓扑相关的疾病或病症的治疗剂。 此外，这些试剂可用于检测趋化因子受体的特定拓扑，从而诊断疾病或疾病倾向。 此外，所述试剂可用于鉴定和分离表达趋化因子受体特定拓扑的细胞。

公开(公告)号：US07442512B2

公开(公告)日：2008-10-28

申请号：US10245850

申请日：2002-09-16

申请人： Jennifer M. Burns ,  Zhenhua Miao ,  Zheng Wei ,  Maureen C. Howard ,  Brett A. Premack ,  Thomas J. Schall

发明人： Jennifer M. Burns ,  Zhenhua Miao ,  Zheng Wei ,  Maureen C. Howard ,  Brett A. Premack ,  Thomas J. Schall

IPC分类号： G01N33/52 ,  G01N33/547 ,  C07K14/52 ,  C07K14/715

CPC分类号： G01N33/6863 ,  G01N33/57407 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57449 ,  G01N2500/10

摘要： The present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of chemokine receptor but not a second topology of the receptor. Such agents are useful as therapeutics for diseases or conditions associated with a particular chemokine receptor topology. Moreover, the agents are useful for detecting a particular topology of a chemokine receptor, thereby diagnosing disease or predisposition for a disease. In addition, the agents are useful for identifying and isolating cells that express a particular topology of a chemokine receptor.

摘要翻译： 本发明提供用于鉴定特异性结合和/或调节趋化因子受体的一个拓扑但不是受体的第二拓扑的试剂的方法。 这样的试剂可用作与特定趋化因子受体拓扑相关的疾病或病症的治疗剂。 此外，这些试剂可用于检测趋化因子受体的特定拓扑，从而诊断疾病或疾病倾向。 此外，所述试剂可用于鉴定和分离表达趋化因子受体特定拓扑的细胞。