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1.发明授权Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors 有权用于检测和治疗与趋化因子受体相关的疾病和病症的组合物和方法公开(公告)号：US07413866B2
公开(公告)日：2008-08-19
申请号：US10452015
申请日：2003-05-30
申请人： Jennifer M. Burns , Zhenhua Miao , Zheng Wei , Maureen C. Howard , Brett A. Premack , Thomas J. Schall
发明人： Jennifer M. Burns , Zhenhua Miao , Zheng Wei , Maureen C. Howard , Brett A. Premack , Thomas J. Schall
CPC分类号： G01N33/6863 , G01N2500/10
摘要： The present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of a chemokine receptor but not a second topology of the receptor. Such agents are useful as therapeutics for diseases or conditions associated with a particular chemokine receptor topology. Moreover, the agents are useful for detecting a particular topology of a chemokine receptor, thereby diagnosing disease or predisposition for a disease. In addition, the agents are useful for identifying and isolating cells that express a particular topology of a chemokine receptor.
摘要翻译： 本发明提供用于鉴定特异性结合和/或调节趋化因子受体的一个拓扑但不是受体的第二拓扑结构的试剂的方法。 这样的试剂可用作与特定趋化因子受体拓扑相关的疾病或病症的治疗剂。 此外，这些试剂可用于检测趋化因子受体的特定拓扑，从而诊断疾病或疾病倾向。 此外，所述试剂可用于鉴定和分离表达趋化因子受体特定拓扑的细胞。
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2.发明授权Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors 有权用于检测和治疗与趋化因子受体相关的疾病和病症的组合物和方法公开(公告)号：US07442512B2
公开(公告)日：2008-10-28
申请号：US10245850
申请日：2002-09-16
申请人： Jennifer M. Burns , Zhenhua Miao , Zheng Wei , Maureen C. Howard , Brett A. Premack , Thomas J. Schall
发明人： Jennifer M. Burns , Zhenhua Miao , Zheng Wei , Maureen C. Howard , Brett A. Premack , Thomas J. Schall
IPC分类号： G01N33/52 , G01N33/547 , C07K14/52 , C07K14/715
CPC分类号： G01N33/6863 , G01N33/57407 , G01N33/57411 , G01N33/57415 , G01N33/57449 , G01N2500/10
摘要： The present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of chemokine receptor but not a second topology of the receptor. Such agents are useful as therapeutics for diseases or conditions associated with a particular chemokine receptor topology. Moreover, the agents are useful for detecting a particular topology of a chemokine receptor, thereby diagnosing disease or predisposition for a disease. In addition, the agents are useful for identifying and isolating cells that express a particular topology of a chemokine receptor.
摘要翻译： 本发明提供用于鉴定特异性结合和/或调节趋化因子受体的一个拓扑但不是受体的第二拓扑的试剂的方法。 这样的试剂可用作与特定趋化因子受体拓扑相关的疾病或病症的治疗剂。 此外，这些试剂可用于检测趋化因子受体的特定拓扑，从而诊断疾病或疾病倾向。 此外，所述试剂可用于鉴定和分离表达趋化因子受体特定拓扑的细胞。
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3.发明申请公开(公告)号：US20110165164A1
公开(公告)日：2011-07-07
申请号：US12964506
申请日：2010-12-09
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/574 , A61P35/00 , A61P35/02
CPC分类号： G01N33/5011 , C07K16/2866 , G01N33/57407 , G01N33/57411 , G01N33/57415 , G01N33/57426 , G01N33/57434 , G01N33/6863 , G01N2500/00
摘要： Ligands of CCX-CKR2 and the biological role of CCX-CKR2 in cancer is described.
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4.发明授权Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors 有权用于检测和治疗与趋化因子受体相关的疾病和病症的组合物和方法公开(公告)号：US07871619B2
公开(公告)日：2011-01-18
申请号：US10912638
申请日：2004-08-04
IPC分类号： A61K39/395 , A61K39/44 , C12P21/08 , C07K16/28
CPC分类号： G01N33/5011 , C07K16/2866 , G01N33/57407 , G01N33/57411 , G01N33/57415 , G01N33/57426 , G01N33/57434 , G01N33/6863 , G01N2500/00
摘要： Ligands of CCX-CKR2 and the biological role of CCX-CKR2 in cancer is described.
摘要翻译： 描述了CCX-CKR2的配体和CCX-CKR2在癌症中的生物学作用。
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5.发明授权Compositions for detecting and treating diseases and conditions related to chemokine receptors 有权用于检测和治疗与趋化因子受体相关的疾病和病症的组合物公开(公告)号：US07777009B2
公开(公告)日：2010-08-17
申请号：US11820743
申请日：2007-06-19
IPC分类号： A61K39/395 , C07K16/24 , C12P21/08
CPC分类号： G01N33/6863 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/26 , C07D211/42 , C07D211/56 , C07D241/04 , C07D241/42 , C07D295/13 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , G01N2500/10
摘要： Antibodies that bind CCX-CKR2 are described.
摘要翻译： 描述了结合CCX-CKR2的抗体。
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6.发明申请Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors 有权用于检测和治疗与趋化因子受体相关的疾病和病症的组合物和方法公开(公告)号：US20090054630A1
公开(公告)日：2009-02-26
申请号：US11820743
申请日：2007-06-19
IPC分类号： C07K16/44
CPC分类号： G01N33/6863 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/26 , C07D211/42 , C07D211/56 , C07D241/04 , C07D241/42 , C07D295/13 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , G01N2500/10
摘要： Antibodies that bind CCX-CKR2 are described.
摘要翻译： 描述了结合CCX-CKR2的抗体。
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7.发明授权Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors 有权用于检测和治疗与趋化因子受体相关的疾病和病症的组合物和方法公开(公告)号：US07253007B2
公开(公告)日：2007-08-07
申请号：US10698541
申请日：2003-10-30
IPC分类号： G01N33/566 , G01N33/567 , A61K45/00
CPC分类号： G01N33/6863 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/26 , C07D211/42 , C07D211/56 , C07D241/04 , C07D241/42 , C07D295/13 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , G01N2500/10
摘要： Ligands of CCX-CKR2 and the biological role of CCX-CKR2 in cancer is described.
摘要翻译： 描述了CCX-CKR2的配体和CCX-CKR2在癌症中的生物学作用。
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8.发明申请COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS 审中-公开检测和治疗与化疗受体相关的疾病和病症的组合物和方法公开(公告)号：US20110052589A1
公开(公告)日：2011-03-03
申请号：US12814163
申请日：2010-06-11
IPC分类号： A61K39/395 , A61P35/00 , A61K31/13 , A61K31/4439 , G01N33/574
CPC分类号： G01N33/6863 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/26 , C07D211/42 , C07D211/56 , C07D241/04 , C07D241/42 , C07D295/13 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , G01N2500/10
摘要： Ligands of CCX-CKR2 and the biological role of CCX-CKR2 in cancer is described.
摘要翻译： 描述了CCX-CKR2的配体和CCX-CKR2在癌症中的生物学作用。
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公开(公告)号：US06207155B1
公开(公告)日：2001-03-27
申请号：US09073599
申请日：1998-05-06
IPC分类号： A61K39395
CPC分类号： C07K16/2866 , A61K2039/505 , A61K2039/545 , Y10S514/885
摘要： Binding compositions and various methods of use of the binding compositions are provided. In particular, a method is provided which comprises administering an effective amount of the binding composition, alone or in combination with other compounds, to eosinophils, thereby reducing the level of eosinophils in an individual. Preferably, the binding composition is a monoclonal antibody specific for CCR3.
摘要翻译： 提供了结合组合物和各种使用结合组合物的方法。 特别地，提供了一种方法，其包括将有效量的结合组合物单独或与其它化合物组合施用于嗜酸性粒细胞，从而降低个体嗜酸性粒细胞的水平。 优选地，结合组合物是CCR3特异的单克隆抗体。
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