公开(公告)号：US07115655B2

公开(公告)日：2006-10-03

申请号：US10510923

申请日：2002-04-09

申请人： Jeong-Seon Yoon ,  Ji-Young Lee ,  Young-Choong Kim ,  Ki-Yong Lee ,  Sang-Hyun Sung ,  Hak-Joong Kim ,  So-Young Kang

发明人： Jeong-Seon Yoon ,  Ji-Young Lee ,  Young-Choong Kim ,  Ki-Yong Lee ,  Sang-Hyun Sung ,  Hak-Joong Kim ,  So-Young Kang

IPC分类号： A61K31/35

CPC分类号： C07D493/04

摘要： The present invention relates to compounds of the following formula (I) or pharmaceutically acceptable salts thereof. The present invention also relates to use for a cognitive-enhancing agent of compounds of the following formula (I) or pharmaceutically acceptable salts thereof and to a process for preparing the same. Further, the present invention relates to use for a congnitive-enhancing agent of decursin of the following formula (II) or pharmaceutically acceptable salts thereof. In addition, the present invention relates to extracts of Angelica gigantis Radix comprising decursin of the following formula (II), having cognitive-enhancing effects.

摘要翻译： 本发明涉及下式（I）的化合物或其药学上可接受的盐。 本发明还涉及下式（I）化合物或其药学上可接受的盐的认知增强剂及其制备方法的用途。 此外，本发明涉及下式（II）的前胡素的认知增强剂或其药学上可接受的盐的用途。 此外，本发明涉及包含具有认知增强作用的下式（II）的前胡素的当归提取物。

公开(公告)号：US20050222245A1

公开(公告)日：2005-10-06

申请号：US10510923

申请日：2002-04-09

申请人： Jeong-Seon Yoon ,  Ji-Young Lee ,  Young-Choong Kim ,  Ki-Yong Lee ,  Sang-Hyun Sung ,  Hak-Joong Kim ,  So-Young Kang

发明人： Jeong-Seon Yoon ,  Ji-Young Lee ,  Young-Choong Kim ,  Ki-Yong Lee ,  Sang-Hyun Sung ,  Hak-Joong Kim ,  So-Young Kang

IPC分类号： C07D493/04 ,  A61K31/366 ,  C07D493/02

CPC分类号： C07D493/04

摘要： The present invention relates to compounds of the following formula (I) or pharmaceutically acceptable salts thereof. The present invention also relates to use for a cognitive-enhancing agent of compounds of the following formula (I) or pharmaceutically acceptable salts thereof and to a process for preparing the same. Further, the present invention relates to use for a congnitive-enhancing agent of decursin of the following formula (II) or pharmaceutically acceptable salts thereof. In addition, the present invention relates to extracts of Angelica gigantis Radix comprising decursin of the following formula (II), having cognitive-enhancing effects.

摘要翻译： 本发明涉及下式（I）的化合物或其药学上可接受的盐。 本发明还涉及下式（I）化合物或其药学上可接受的盐的认知增强剂及其制备方法的用途。 此外，本发明涉及下式（II）的前胡素的认知增强剂或其药学上可接受的盐的用途。 此外，本发明涉及包含具有认知增强作用的下式（II）的前胡素的当归提取物。

公开(公告)号：US06511978B1

公开(公告)日：2003-01-28

申请号：US09958478

申请日：2001-10-11

申请人： Jong-Sung Koh ,  Hyun-Il Lee ,  You-Seung Shin ,  Hak-Joong Kim ,  Jin-Ho Lee ,  Jong-Hyun Kim ,  Hyun-Ho Chung ,  Shin-Wu Jeong ,  Tae-Saeng Choi ,  Jung-Kwon Yoo ,  Chung-Mi Kim ,  Kwi-Hwa Kim ,  Sun-Hwa Lee ,  Sang-Kyun Lee

发明人： Jong-Sung Koh ,  Hyun-Il Lee ,  You-Seung Shin ,  Hak-Joong Kim ,  Jin-Ho Lee ,  Jong-Hyun Kim ,  Hyun-Ho Chung ,  Shin-Wu Jeong ,  Tae-Saeng Choi ,  Jung-Kwon Yoo ,  Chung-Mi Kim ,  Kwi-Hwa Kim ,  Sun-Hwa Lee ,  Sang-Kyun Lee

IPC分类号： C07D40306

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14

摘要： The present invention relates to a novel pyrrole derivative which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof; to a process for preparation of said compound; and to a pharmaceutical composition such as anti-cancer composition, etc. comprising said compound as an active ingredient together with pharmaceutically acceptable carrier.

摘要翻译： 本发明涉及对法呢基转移酶或其药学上可接受的盐或异构体具有抑制活性的新型吡咯衍生物; 涉及制备所述化合物的方法; 以及包含所述化合物作为活性成分以及药学上可接受的载体的药物组合物，例如抗癌组合物等。