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![Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof](/abs-image/US/2010/02/04/US20100029657A1/abs.jpg.150x150.jpg)
1.发明申请Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof 审中-公开吡唑并[1,5-A]嘧啶的双环杂环或螺环双环杂环衍生物，其制备方法及用途公开(公告)号：US20100029657A1
公开(公告)日：2010-02-04
申请号：US12393565
申请日：2009-02-26
申请人： Jeremy Ian Levin , Darrin William Hopper , Nancy Torres , Minu Dhanjisha Dutia , Dan Maarten Berger , Xiaolun Wang , Martin Joseph Di Grandi , Chunchun Zhang , Alejandro Lee Dunnick
发明人： Jeremy Ian Levin , Darrin William Hopper , Nancy Torres , Minu Dhanjisha Dutia , Dan Maarten Berger , Xiaolun Wang , Martin Joseph Di Grandi , Chunchun Zhang , Alejandro Lee Dunnick
IPC分类号： A61K31/4985 , C07D487/04 , A61K31/519 , A61P35/00 , A61P29/00
CPC分类号： C07D519/00
摘要： Compounds of formula A: and pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by Raf kinases.
摘要翻译： 描述了式A的化合物及其药学上可接受的盐，其选择性地抑制Raf激酶活性，并且可用于治疗由Raf激酶介导的病症。
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![PYRAZOLO[5, 1-C] [1,2,4] TRIAZINES, METHODS FOR PREPARATION AND USE THEREOF](/abs-image/US/2009/03/26/US20090082354A1/abs.jpg.150x150.jpg)
2.发明申请PYRAZOLO[5, 1-C] [1,2,4] TRIAZINES, METHODS FOR PREPARATION AND USE THEREOF 审中-公开吡咯并[5,1-C] [1,2,4]三嗪类，其制备方法和用途公开(公告)号：US20090082354A1
公开(公告)日：2009-03-26
申请号：US12233877
申请日：2008-09-19
IPC分类号： A61K31/53 , C07D487/04
CPC分类号： C07D487/04
摘要： A pyrazolo[5,1-c][1,2,4]triazine compound of formula A: and pharmaceutically acceptable sats thereof. The multiply-substituted pyrazolo[5,1-c][1,2,4]triazine compounds of the invention selectively inhibit B-Raf kinase activity and are useful for treating disorders mediated by B-Raf kinase.
摘要翻译： 式A的吡唑并[5,1-c] [1,2,4]三嗪化合物及其药学上可接受的盐。 本发明的多取代的吡唑并[5,1-c] [1,2,4]三嗪化合物选择性地抑制B-Raf激酶活性，并且可用于治疗由B-Raf激酶介导的病症。
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3.发明申请THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS 审中-公开作为B-RAF抑制剂的三亚甲基嘧啶，三亚甲基吡啶和吡咯并嘧啶公开(公告)号：US20090118276A1
公开(公告)日：2009-05-07
申请号：US12262622
申请日：2008-10-31
申请人： Ariamala Gopalsamy , Mengxiao Shi , Dan Maarten Berger , Minu Dhanjisha Dutia , Nancy Torres , Darrin William Hopper
发明人： Ariamala Gopalsamy , Mengxiao Shi , Dan Maarten Berger , Minu Dhanjisha Dutia , Nancy Torres , Darrin William Hopper
IPC分类号： A61K31/5377 , C07D495/04 , C07D487/04 , A61K31/519
CPC分类号： C07D491/04 , C07D495/04
摘要： The present invention relates to compounds of formula la: and pharmaceutically acceptable salts thereof. The thieno[3,2-d]pyrimidine, thieno[2,3-d]pyrimidine, thieno[3,2-b]pyridine, thieno[2,3-b]pyridine, and pyrrolo[2,3-d]pyrimidine compounds selectively inhibit B-Raf kinase activity and are useful for treating disorders mediated by B-Raf kinase, and for the treatment of cancer.
摘要翻译： 本发明涉及式Ia化合物及其药学上可接受的盐。 噻吩并[3,2-d]嘧啶，噻吩并[2,3-d]嘧啶，噻吩并[3,2-b]吡啶，噻吩并[2,3-b]吡啶和吡咯并[2,3-d] 嘧啶化合物选择性地抑制B-Raf激酶活性，并且可用于治疗由B-Raf激酶介导的疾病和用于治疗癌症。
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