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公开(公告)号：US07435726B2
公开(公告)日：2008-10-14
申请号：US09853617
申请日：2001-05-14
申请人： Jerome B. Zeldis , Andrew L. Zeitlin , Sol Barer
发明人： Jerome B. Zeldis , Andrew L. Zeitlin , Sol Barer
CPC分类号： A61K31/4745 , A61K31/454 , A61K31/47 , A61K31/7056 , A61K31/724 , A61K31/445 , A61K2300/00
摘要： This invention relates to compositions comprising thalidomide and another anti-cancer drug which can be used in the treatment or prevention of cancer. Preferred anti-cancer drugs are topoisomerase inhibitors. A particular composition comprises thalidomide, or a pharmaceutically acceptable salt, solvate, or clathrate thereof, and irinotecan. The invention also relates to methods of treating or preventing cancer which comprise the administration of a thalidomide and another anti-cancer drug to a patient in need of such treatment or prevention. The invention further relates to methods of reducing or avoiding adverse side effects associated with the administration of chemotherapy or radiation therapy which comprise the administration of thalidomide to a patient in need of such reduction or avoidance.
摘要翻译： 本发明涉及可用于治疗或预防癌症的沙利度胺和另一种抗癌药物的组合物。 优选的抗癌药物是拓扑异构酶抑制剂。 特定组合物包含沙利度胺或其药学上可接受的盐，溶剂合物或包合物和伊立替康。 本发明还涉及治疗或预防癌症的方法，其包括向需要这种治疗或预防的患者施用沙利度胺和另一种抗癌药物。 本发明还涉及减少或避免与化疗或放射治疗相关的不良副作用的方法，其包括向需要这种减少或避免的患者施用沙利度胺。
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2.发明申请METHODS FOR TREATMENT OF COGNITIVE AND MENOPAUSAL DISORDERS WITH D-THREO METHYLPHENIDATE 审中-公开用甲基苯甲酸D-THREO治疗认知障碍和男性疾病的方法公开(公告)号：US20130053414A1
公开(公告)日：2013-02-28
申请号：US13661472
申请日：2012-10-26
申请人： Jerome B. Zeldis , Herbert J. Faleck , Vikram Khetani , Andrew L. Zeitlin , Maghsoud M. Dariani , David I. Stirling
发明人： Jerome B. Zeldis , Herbert J. Faleck , Vikram Khetani , Andrew L. Zeitlin , Maghsoud M. Dariani , David I. Stirling
IPC分类号： A61K31/4458 , A61P25/00 , A61P25/24 , A61P3/00
CPC分类号： C07D211/34 , A61K31/4458 , A61K45/06 , C12P17/12 , C12P41/006 , A61K2300/00
摘要： In one aspect, the present invention is directed to methods for treating fatigue, neurobehavioral slowing and other cognitive disorders and defects due to cancers and treatments associated with cancers, and similar conditions. In a further aspect, the present invention is directed to methods for treating disorders related to menopause, including executive function defects. The methods involve the administration of a composition comprising D-threo methylphenidate that is substantially free of L-threo methylphenidate and of erythro forms of methylphenidate.
摘要翻译： 一方面，本发明涉及用于治疗疲劳，神经行为减缓以及由于与癌症相关的癌症和治疗以及类似病症引起的其他认知障碍和缺陷的方法。 在另一方面，本发明涉及治疗与绝经相关的疾病的方法，包括执行功能缺陷。 所述方法包括施用包含基本上不含L-苏雷哌甲酯的D-苏雷哌甲酯和红皮质哌甲酯的组合物。
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公开(公告)号：US06602887B2
公开(公告)日：2003-08-05
申请号：US09864617
申请日：2001-05-24
IPC分类号： A61K31445
CPC分类号： A61K31/445 , A61K9/1676 , A61K9/2886 , A61K9/5078 , A61K9/5084 , A61K31/4458 , C07D211/34 , C12P17/12 , C12P41/006
摘要： Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the invention are useful in treating nervous system disorders including attention deficit disorder, attention deficit hyperactivity disorder, and cognitive decline associated with systemic diseases such as acquired immunodeficiency syndrome.
摘要翻译： 提供了D-三苯哌甲酯的慢性推注。 D-苏糖异构体的给药消除了与DL外消旋相关的不利副作用，并提供了改善的效果。 本发明的组合物和方法可用于治疗神经系统疾病，包括注意力缺陷障碍，注意缺陷多动障碍以及与系统性疾病如获得性免疫缺陷综合征相关的认知衰退。
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4.发明申请Methods For Treatment Of Cognitive And Menopausal Disorders With D-Threo Methylphenidate 审中-公开用D-Threo哌甲酯治疗认知障碍和绝经期疾病的方法公开(公告)号：US20100093797A1
公开(公告)日：2010-04-15
申请号：US12640734
申请日：2009-12-17
申请人： Jerome B. Zeldis , Herbert J. Faleck , Vikram Khetani , Andrew L. Zeitlin , Maghsoud M. Dariani , David I. Stirling
发明人： Jerome B. Zeldis , Herbert J. Faleck , Vikram Khetani , Andrew L. Zeitlin , Maghsoud M. Dariani , David I. Stirling
IPC分类号： A61K31/445 , A61P15/00 , A61P35/04
CPC分类号： C07D211/34 , A61K31/4458 , A61K45/06 , C12P17/12 , C12P41/006 , A61K2300/00
摘要： In one aspect, the present invention is directed to methods for treating fatigue, neurobehavioral slowing and other cognitive disorders and defects due to cancers and treatments associated with cancers, and similar conditions. In a further aspect, the present invention is directed to methods for treating disorders related to menopause, including executive function defects. The methods involve the administration of a composition comprising D-threo methylphenidate that is substantially free of L-threo methylphenidate and of erythro forms of methylphenidate.
摘要翻译： 一方面，本发明涉及用于治疗疲劳，神经行为减缓以及由于与癌症相关的癌症和治疗以及类似病症引起的其他认知障碍和缺陷的方法。 在另一方面，本发明涉及治疗与绝经相关的疾病的方法，包括执行功能缺陷。 所述方法包括施用包含基本上不含L-苏雷哌甲酯的D-苏雷哌甲酯和红皮质哌甲酯的组合物。
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公开(公告)号：US06255325B1
公开(公告)日：2001-07-03
申请号：US09337310
申请日：1999-06-21
IPC分类号： A61K31445
CPC分类号： A61K31/445 , A61K9/1676 , A61K9/2886 , A61K9/5078 , A61K9/5084 , A61K31/4458 , C07D211/34 , C12P17/12 , C12P41/006
摘要： Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the invention are useful in treating nervous system disorders including attention deficit disorder, attention deficit hyperactivity disorder, and cognitive decline associated with systemic diseases such as acquired immunodeficiency syndrome.
摘要翻译： 提供了
D - 特异哌甲酯的慢性推注。 D - 苏氨酸异构体的给药消除了与 DL 外消旋体相关的不良副作用，并提供更好的效果。 本发明的组合物和方法可用于治疗神经系统疾病，包括注意力缺陷障碍，注意缺陷多动障碍以及与系统性疾病如获得性免疫缺陷综合征相关的认知衰退。 -
公开(公告)号：US5922736A
公开(公告)日：1999-07-13
申请号：US937684
申请日：1997-09-29
IPC分类号： A61K9/16 , A61K9/28 , A61K9/50 , A61K9/54 , A61K31/4458 , A61P25/28 , C07D211/34 , C12P17/12 , C12P41/00 , A61K31/445
CPC分类号： A61K31/445 , A61K31/4458 , A61K9/1676 , A61K9/2886 , A61K9/5078 , A61K9/5084 , C07D211/34 , C12P17/12 , C12P41/006
摘要： Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the invention are useful in treating nervous system disorders including attention deficit disorder, attention deficit hyperactivity disorder, and cognitive decline associated with systemic diseases such as acquired immunodeficiency syndrome.
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公开(公告)号：US20090088455A1
公开(公告)日：2009-04-02
申请号：US12331127
申请日：2008-12-09
IPC分类号： A61K31/4458 , A61P25/00
CPC分类号： A61K31/445 , A61K9/1676 , A61K9/2886 , A61K9/5078 , A61K9/5084 , A61K31/4458 , C07D211/34 , C12P17/12 , C12P41/006
摘要： Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the invention are useful in treating nervous system disorders including attention deficit disorder, attention deficit hyperactivity disorder, and cognitive decline associated with systemic diseases such as acquired immunodeficiency syndrome.
摘要翻译： 提供了D-三苯哌甲酯的慢性推注。 D-苏糖异构体的给药消除了与DL外消旋相关的不利副作用，并提供了改善的效果。 本发明的组合物和方法可用于治疗神经系统疾病，包括注意力缺陷障碍，注意缺陷多动障碍以及与系统性疾病如获得性免疫缺陷综合征相关的认知衰退。
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公开(公告)号：US08440194B2
公开(公告)日：2013-05-14
申请号：US12070451
申请日：2008-02-19
申请人： Jerome B. Zeldis
发明人： Jerome B. Zeldis
IPC分类号： A61K39/395 , A61K31/70 , A61K31/445 , A01N43/04 , A01N43/40
CPC分类号： A61K31/454 , A61K31/00 , A61K31/198 , A61K31/40 , A61K31/425 , A61K31/445 , A61K31/515 , A61K31/573 , A61K31/7076 , A61K38/00 , A61K39/39541 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2887 , C07K2317/24 , A61K2300/00
摘要： Methods of treating, preventing or managing leukemias are disclosed. The methods encompass the administration of an immunomodulatory compound of the invention known as Revlimid® or lenalidomide. The invention further relates to methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods of the invention are also disclosed.
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9.发明授权Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione in combination with a proteasome inhibitor 有权使用3-（4-氨基-1-氧代-1,3-二氢异吲哚-2-基） - 哌啶-2,6-二酮与蛋白酶体抑制剂联合治疗多发性骨髓瘤的方法公开(公告)号：US08198306B2
公开(公告)日：2012-06-12
申请号：US12640702
申请日：2009-12-17
申请人： Jerome B. Zeldis
发明人： Jerome B. Zeldis
IPC分类号： A01N43/40
CPC分类号： A61K31/454 , A61K9/0053 , A61K9/4858 , A61K9/4866 , A61K31/00 , A61K31/198 , A61K31/40 , A61K31/4035 , A61K31/425 , A61K31/4439 , A61K31/445 , A61K31/475 , A61K31/515 , A61K31/573 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K35/12 , A61K39/0011 , A61K39/3955 , A61K45/06 , A61K2300/00
摘要： Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
摘要翻译： 公开了治疗，预防和/或控制癌症以及与不期望的血管发生相关或特征在于不期望的血管生成的疾病和病症的方法。 具体方法包括单独或与第二活性成分组合施用免疫调节化合物。 本发明还涉及减少或避免与包括施用免疫调节化合物的化学疗法，放射疗法，激素疗法，生物疗法或免疫疗法相关的不良副作用的方法。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。
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10.发明申请METHODS AND COMPOSITIONS USING PDE4 INHIBITORS FOR THE TREATMENT AND MANAGEMENT OF CANCERS 审中-公开使用PDE4抑制剂治疗癌症的方法和组合物公开(公告)号：US20100129363A1
公开(公告)日：2010-05-27
申请号：US12621445
申请日：2009-11-18
申请人： Jerome B. Zeldis , Peter H. Schafer
发明人： Jerome B. Zeldis , Peter H. Schafer
IPC分类号： A61K39/395 , A61K31/40 , A61P35/02
CPC分类号： A61K31/4035 , A61K31/496 , A61K31/704 , A61K31/724
摘要： Methods of treating, preventing and/or managing hematological cancers are disclosed. Specific methods encompass the administration of a PDE4 inhibitor alone or in combination with a second active agent. The invention further relates to methods of treating leukemias and lymphomas which comprise the administration of a PDE4 inhibitor. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
摘要翻译： 公开了治疗，预防和/或治疗血液癌症的方法。 具体方法包括单独或与第二活性剂组合施用PDE4抑制剂。 本发明还涉及治疗白血病和淋巴瘤的方法，其包括施用PDE4抑制剂。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。
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