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公开(公告)号:US20070010534A1
公开(公告)日:2007-01-11
申请号:US11533034
申请日:2006-09-19
申请人: Jerry Adams , Neil Johnson , Jeffrey Murray
发明人: Jerry Adams , Neil Johnson , Jeffrey Murray
IPC分类号: A61K31/513 , A61K31/506 , A61K31/4439 , C07D403/04
CPC分类号: C07D409/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/14
摘要: The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases, in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred.
摘要翻译: 本发明涉及用于治疗哺乳动物疾病发生不适当,过度或不需要的血管发生和/或发生过度Tie2受体活性的新型式(I)化合物。
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公开(公告)号:US20110269774A1
公开(公告)日:2011-11-03
申请号:US13097271
申请日:2011-04-29
申请人: Jerry ADAMS , Thomas Faitg , Neil Johnson , Jiri Kasparec , Hong Lin , Mark Mellinger , Xin Peng , Ren Xie
发明人: Jerry ADAMS , Thomas Faitg , Neil Johnson , Jiri Kasparec , Hong Lin , Mark Mellinger , Xin Peng , Ren Xie
IPC分类号: A61K31/497 , C07D401/12 , A61P35/00 , A61K31/44 , A61K31/4439 , C07D211/72 , C07D409/14
CPC分类号: A61K31/4439 , A61K31/337 , A61K31/4375 , A61K31/47 , C07D401/12 , C07D401/14 , G01N33/57423
摘要: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中R 1,R 2,R 3,R 11,R 12,R 13,Q,Z和p如本文所述。 本发明的化合物可用于治疗癌症。
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公开(公告)号:US20140308104A1
公开(公告)日:2014-10-16
申请号:US14251406
申请日:2014-04-11
申请人: Neil Johnson , Jay Ragsdale
发明人: Neil Johnson , Jay Ragsdale
IPC分类号: B60P1/40
CPC分类号: B60P1/40 , B65G43/08 , B65G47/19 , B65G47/5195 , B65G65/005
摘要: The present disclosure is directed to a system for controlling dispersal of a granular material from a transport assembly. In an implementation, a system includes a transport assembly including a transport storage receptacle configured to receive granular material, and a payload deposit assembly coupled to transport storage receptacle. The payload assembly configured to disperse the granular material. A location-determining device coupled to the transport assembly. The location-determining device is configured to determine a position of the transport assembly with respect to a storage receptacle. A control mechanism is coupled to the transport storage receptacle, and the control mechanism is configured to control dispersal of the granular material. An electronic device is operatively coupled to the control mechanism. The electronic device is configured to allow dispersal of the granular material from the transport storage receptacle when the transport assembly is correctly positioned with respect to the storage receptacle.
摘要翻译: 本公开涉及一种用于控制从运输组件分散粒状材料的系统。 在一个实施方案中,系统包括传输组件,其包括配置成接收颗粒材料的运输存储容器以及耦合到运输存储容器的有效载荷沉积组件。 有效载荷组件构造成分散颗粒材料。 耦合到所述输送组件的位置确定装置。 位置确定装置被配置为确定运输组件相对于存储容器的位置。 控制机构联接到运输存储容器,并且控制机构被配置为控制颗粒材料的分散。 电子设备可操作地耦合到控制机构。 电子设备被构造成当运输组件相对于存储容器正确定位时允许从运输存储容器分散粒状材料。
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公开(公告)号:US20130059849A1
公开(公告)日:2013-03-07
申请号:US13696601
申请日:2011-05-05
申请人: Joelle Lorraine Burgess , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma , Dominic Suarez
发明人: Joelle Lorraine Burgess , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma , Dominic Suarez
IPC分类号: A61K31/444 , A61P35/00 , A61K31/506 , A61K31/5377 , A61K31/496 , A61K31/513 , C07D471/04 , A61K31/4545
CPC分类号: C07D471/04 , C07D519/00
摘要: Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.
摘要翻译: 本文公开了式(I)的氮杂吲唑,其中各种基团在本文中定义,并且其可用于治疗癌症。
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公开(公告)号:US20130053383A1
公开(公告)日:2013-02-28
申请号:US13696436
申请日:2011-05-05
申请人: Celine Duquenne , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma
发明人: Celine Duquenne , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma
IPC分类号: A61K31/4439 , A61P35/00 , A61P35/02 , C07D401/14 , A61K31/4545 , A61K31/496 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D409/14 , C07D401/12 , A61K31/444
CPC分类号: C07D409/14 , C07D401/12 , C07D401/14 , C07D471/04
摘要: Herein are disclosed indazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.
摘要翻译: 本文公开了式(I)的吲唑,其中各种基团在本文中定义,并且其可用于治疗癌症。
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公开(公告)号:US20110295583A1
公开(公告)日:2011-12-01
申请号:US13118114
申请日:2011-05-27
申请人: STEPHEN HOLLOCK , Neil Johnson , Nicola Cross
发明人: STEPHEN HOLLOCK , Neil Johnson , Nicola Cross
IPC分类号: G06G7/60
CPC分类号: G06K9/00335 , G06K9/00771 , G08B21/0476 , G08B31/00
摘要: A system and method of identifying changes in behavior of a human subject comprises monitoring the movements of the subject within a space using one or more sensors, processing signals from the sensor(s) to determine values for one or more parameters associated with one or more patterns of behavior of the subject, using values for the one or more parameters accumulated over a period of time to establish one or more models of a typical pattern of behavior for the subject, monitoring the ongoing behavior of the subject to obtain current values for one or more of the parameters; and using the current values and the model(s) of a typical pattern of behavior to identify atypical behavior of the subject.An alert may be generated if the current value of one or more of the parameters is outside the acceptable limit(s). Advantageously low resolution thermal imagers are used so as to minimise intrusiveness and invasion of privacy.
摘要翻译: 识别人类对象的行为变化的系统和方法包括使用一个或多个传感器来监测在空间内的对象的运动,处理来自传感器的信号以确定与一个或多个相关联的一个或多个参数的值 利用一段时间内累积的一个或多个参数的值来确定受试者的典型行为模式的一个或多个模型,监测受试者的持续行为以获得当前值 或更多的参数; 并使用当前值和典型行为模式的模型来识别受试者的非典型行为。 如果一个或多个参数的当前值超出可接受的限制,则可能会生成警报。 有利的是使用低分辨率热成像仪来最小化隐私的侵入性和侵入性。
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公开(公告)号:US06170364B2
公开(公告)日:2001-01-09
申请号:US09358758
申请日:1999-07-22
申请人: Neil Johnson
发明人: Neil Johnson
IPC分类号: B25B1356
CPC分类号: B25B13/48
摘要: A golf shoe spike tool used for installing or removing golf spikes made of polyurethane or similar material. The tool has a handle, a head and shaft between the head and handle. The head has a plurality of teeth with engage a spike. Through rotational force, the spike is installed or removed from a golf.
摘要翻译: 用于安装或去除由聚氨酯或类似材料制成的高尔夫球钉的高尔夫球鞋钉工具。 该工具在头部和手柄之间具有手柄,头部和轴。 头部具有多个啮合尖峰的齿。 通过旋转力,尖峰安装或从高尔夫球上移除。
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公开(公告)号:US09481281B2
公开(公告)日:2016-11-01
申请号:US14251406
申请日:2014-04-11
申请人: Neil Johnson , Jay Ragsdale
发明人: Neil Johnson , Jay Ragsdale
CPC分类号: B60P1/40 , B65G43/08 , B65G47/19 , B65G47/5195 , B65G65/005
摘要: The present disclosure is directed to a system for controlling dispersal of a granular material from a transport assembly. In an implementation, a system includes a transport assembly including a transport storage receptacle configured to receive granular material, and a payload deposit assembly coupled to transport storage receptacle. The payload assembly configured to disperse the granular material. A location-determining device coupled to the transport assembly. The location-determining device is configured to determine a position of the transport assembly with respect to a storage receptacle. A control mechanism is coupled to the transport storage receptacle, and the control mechanism is configured to control dispersal of the granular material. An electronic device is operatively coupled to the control mechanism. The electronic device is configured to allow dispersal of the granular material from the transport storage receptacle when the transport assembly is correctly positioned with respect to the storage receptacle.
摘要翻译: 本公开涉及一种用于控制从运输组件分散粒状材料的系统。 在一个实施方案中,系统包括传输组件,其包括配置成接收颗粒材料的运输存储容器以及耦合到运输存储容器的有效载荷沉积组件。 有效载荷组件构造成分散颗粒材料。 耦合到所述输送组件的位置确定装置。 位置确定装置被配置为确定运输组件相对于存储容器的位置。 控制机构联接到运输存储容器,并且控制机构被配置为控制颗粒材料的分散。 电子设备可操作地耦合到控制机构。 电子设备被构造成当运输组件相对于存储容器正确定位时允许从运输存储容器分散粒状材料。
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公开(公告)号:US09000926B2
公开(公告)日:2015-04-07
申请号:US13118127
申请日:2011-05-27
申请人: Stephen Hollock , Neil Johnson , Nicola Cross
发明人: Stephen Hollock , Neil Johnson , Nicola Cross
CPC分类号: G08B21/245
摘要: A method of monitoring hand washing by individuals comprises monitoring the movements of individuals in an area using one or more sensors, identifying the performance of an act by an individual that requires the hands of the individual to be washed and determining whether the hands of the individual are washed after the performance of the act, wherein the determining includes tracking the motion of that individual using the one or more sensors. Sensors comprising arrays of thermal detectors are preferred, but other types of sensor could be included.
摘要翻译: 监控个人手洗的方法包括使用一个或多个传感器来监测个人在某个区域中的移动,识别需要个人的手洗涤的个人的行为的表现,并且确定个体的手 在所述动作的执行之后被洗涤,其中所述确定包括使用所述一个或多个传感器跟踪所述个体的运动。 包括热检测器阵列的传感器是优选的,但是可以包括其它类型的传感器。
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公开(公告)号:US08731241B2
公开(公告)日:2014-05-20
申请号:US12977745
申请日:2010-12-23
申请人: Neil Johnson , Glyn Cowe
发明人: Neil Johnson , Glyn Cowe
CPC分类号: G06K9/00771 , G07C9/00 , G07C2011/04 , G08B13/19613
摘要: A system for monitoring the motion of objects is configured to identify objects meeting predetermined criteria appearing in a scene and to track the motion of identified objects across the scene. In a particular embodiment the system is configured to compile statistical data for multiple points or regions to indicate one or both of: the frequency with which objects are initialised at that region or point; and the frequency with which initialised objects cross the region or point. The initialisation data will indicate the areas in the scene where objects are most frequently initialised. If the statistical data shows an area of the scene in which objects are never initialised this might indicate that there is an obstruction between objects that need to be tracked and the detector. The path data will indicate the paths most frequently followed by objects. If there is a particularly well trodden path to and fro in a particular part of the scene this might distort the result of a count of people entering and leaving a region in the scene.
摘要翻译: 用于监视对象的运动的系统被配置为识别符合出现在场景中的预定标准的对象,并且跟踪所述场景上识别的对象的运动。 在特定实施例中,系统被配置为编辑多个点或区域的统计数据,以指示以下一个或两个:在该区域或点处对象被初始化的频率; 以及初始化对象穿过区域或点的频率。 初始化数据将指示对象最常被初始化的场景中的区域。 如果统计数据显示对象从未被初始化的场景的区域,则这可能表明需要跟踪的对象与检测器之间存在阻塞。 路径数据将指示对象最为常见的路径。 如果在场景的特定部分有一个特别好的道路,这可能会扭曲人们进入和离开现场的一个地区的结果。
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