公开(公告)号：US09266878B2

公开(公告)日：2016-02-23

申请号：US14686418

申请日：2015-04-14

申请人： Jerry Evarts ,  Leena Patel ,  Jennifer A. Treiberg ,  Stephane Perreault ,  Arthur Yeung ,  Lafe J. Purvis, II ,  Musong Kim

发明人： Jerry Evarts ,  Leena Patel ,  Jennifer A. Treiberg ,  Stephane Perreault ,  Arthur Yeung ,  Lafe J. Purvis, II ,  Musong Kim

IPC分类号： C07D417/14 ,  C07D403/12 ,  C07D401/14 ,  C07D403/14 ,  C07D471/08

CPC分类号： C07D417/14 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D471/08

摘要： The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (I), or pharmaceutically acceptable salts thereof, in which R1, R2, n, R3, R4, R5 and R6 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more PI3K isoforms, such as PI3Kδ. The present disclosure further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms, such as PI3Kδ.

公开(公告)号：US20150218154A1

公开(公告)日：2015-08-06

申请号：US14686418

申请日：2015-04-14

申请人： Jerry Evarts ,  Leena Patel ,  Jennifer A. Treiberg ,  Stephane Perreault ,  Arthur Yeung ,  Lafe J. Purvis, II ,  Musong Kim

发明人： Jerry Evarts ,  Leena Patel ,  Jennifer A. Treiberg ,  Stephane Perreault ,  Arthur Yeung ,  Lafe J. Purvis, II ,  Musong Kim

IPC分类号： C07D417/14 ,  C07D403/14 ,  C07D403/12 ,  C07D401/14

CPC分类号： C07D417/14 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D471/08

摘要： The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (I), or pharmaceutically acceptable salts thereof, in which R1, R2, n, R3, R4, R5 and R6 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more PI3K isoforms, such as PI3Kδ. The present disclosure further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms, such as PI3Kδ.

摘要翻译： 本公开提供式（I）的磷脂酰肌醇3-激酶（PI3K）抑制剂或其药学上可接受的盐，其中R 1，R 2，n，R 3，R 4，R 5和R 6如本文所定义。 这些化合物可用于治疗由一种或多种PI3K异构体如PI3Kδ介导的病症。 本公开进一步提供了包含式（I）化合物或其药学上可接受的盐的药物组合物，以及使用这些化合物和组合物治疗由一种或多种PI3K异构体如PI3Kδ介导的病症的方法。