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公开(公告)号：US06664286B1
公开(公告)日：2003-12-16
申请号：US09787332
申请日：2001-03-15
IPC分类号： A61K31405
CPC分类号： A61K31/4045 , A61K31/00 , Y10S514/913
摘要： Compounds with 5HT2 receptor agonist activity useful for treating glaucoma, including lowering intraocular pressure. Compositions and methods for their use are also disclosed.
摘要翻译： 具有5HT2受体激动剂活性的化合物，可用于治疗青光眼，包括降低眼内压。 还公开了其使用的组合物和方法。
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2.发明授权(Indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines for treating glaucoma and controlling intraocular pressure 失效（吲唑-5-基） - 吡嗪和用于治疗青光眼并控制眼内压的（1,3-二氢 - 吲哚-2-酮） - 吡嗪公开(公告)号：US07655662B2
公开(公告)日：2010-02-02
申请号：US11612894
申请日：2006-12-19
IPC分类号： A61K31/496 , A61K31/55 , A61K31/50 , A61K31/52 , A61K31/19
CPC分类号： C07D403/14 , A61K9/0048 , A61K31/4965 , A61K31/497 , A61K31/557 , C07D403/04
摘要： Methods for using (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines, are disclosed herein.
摘要翻译： 本文公开了使用（吲唑-5-基） - 吡嗪和（1,3-二氢 - 吲哚-2-酮） - 吡嗪的方法来治疗rho激酶介导的疾病或rho激酶介导的病症，包括控制眼内压和 治疗青光眼。 用于治疗眼睛疾病如青光眼的眼用药物组合物，另外可用于控制眼内压，所述组合物包含有效量的（吲唑-5-基） - 吡嗪和（1,3-二氢 - 吲哚-2-基） 一种） - 吡嗪，这里公开。
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公开(公告)号：US07060704B2
公开(公告)日：2006-06-13
申请号：US11100918
申请日：2005-04-07
IPC分类号： C07D241/02 , C07D279/02 , C07D401/12 , A61K31/443 , A61K31/4965
CPC分类号： C07D295/088 , C07D209/08 , C07D217/04 , C07D235/26 , C07D295/13 , C07D401/12 , C07D513/04
摘要： Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.
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4.发明授权Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders 有权用于治疗眼睛和CNS疾病的5-羟色胺能5HT7受体化合物公开(公告)号：US07285553B2
公开(公告)日：2007-10-23
申请号：US11265030
申请日：2005-11-02
IPC分类号： C07D403/00 , C07D401/00 , C07D241/04 , A61K31/495
CPC分类号： C07D295/088 , C07D209/08 , C07D217/04 , C07D235/26 , C07D295/13 , C07D401/12 , C07D513/04
摘要： Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.
摘要翻译： 公开了可用于降低IOP，改善视神经头和视网膜的血流量，提供神经保护和治疗视网膜疾病的具有5HT 7受体亲和力（其中一些是新颖的）的化合物。 化合物还可用于治疗睡眠障碍，抑郁症和其他精神病学障碍，例如精神分裂症，焦虑症，强迫症，昼夜节律紊乱以及中枢和外周介导的高血压。 还公开了其使用的组合物和方法。
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公开(公告)号：US06960579B1
公开(公告)日：2005-11-01
申请号：US09674403
申请日：1999-05-10
IPC分类号： C07D209/08 , C07D295/088 , C07D295/13 , C07D513/04 , A61K31/443 , A61K31/4965 , C07D241/02 , C07D279/02 , C07D401/12
CPC分类号： C07D295/088 , C07D209/08 , C07D217/04 , C07D235/26 , C07D295/13 , C07D401/12 , C07D513/04
摘要： Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.
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公开(公告)号：US07235556B2
公开(公告)日：2007-06-26
申请号：US10824013
申请日：2004-04-14
申请人： Najam A. Sharif , Mark R. Hellberg
发明人： Najam A. Sharif , Mark R. Hellberg
IPC分类号： A61K31/50
CPC分类号： A61K31/5025 , Y10S514/912
摘要： Fused pyridazine derivatives are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
摘要翻译： 稠合的哒嗪衍生物可用于治疗需要润湿眼睛的干眼病和其它病症。
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7.发明授权Bradykinin receptor agonists and uses thereof to treat ocular hypertension and glaucoma 失效缓激肽受体激动剂及其用途来治疗眼高压和青光眼公开(公告)号：US08252793B2
公开(公告)日：2012-08-28
申请号：US13211827
申请日：2011-08-17
申请人： Keith D. Combrink , Suchismita Mohapatra , Mark R. Hellberg , Najam A. Sharif , Ganesh Prasanna , Iok-Hou Pang , Bryon Severns , Hwang-Hsing Chen , Abdelmoula Namil
发明人： Keith D. Combrink , Suchismita Mohapatra , Mark R. Hellberg , Najam A. Sharif , Ganesh Prasanna , Iok-Hou Pang , Bryon Severns , Hwang-Hsing Chen , Abdelmoula Namil
IPC分类号： A61K31/5377 , A61K31/444 , A61K31/496 , A61K31/4545 , A61K31/506 , A61K31/4439 , C07D401/14 , C07D498/04 , C07D413/14 , C07D401/06 , A61P9/12 , A61P27/06
CPC分类号： C07D401/14 , C07D401/06 , C07D401/12 , C07D403/06 , C07D413/14 , C07D498/04
摘要： The invention provides compositions and methods for treating and/or preventing ocular disorders associated with increased intraocular pressure. In particular, the compounds are bradykinin agonists.
摘要翻译： 本发明提供用于治疗和/或预防与增加的眼内压有关的眼部疾病的组合物和方法。 特别地，化合物是缓激肽激动剂。
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8.发明授权Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions 失效用于治疗rho激酶介导的疾病和病症的羟基氨基和氨基取代的吡啶类似物公开(公告)号：US07867999B1
公开(公告)日：2011-01-11
申请号：US11612932
申请日：2006-12-19
IPC分类号： A61K31/35 , A61K31/44 , A61K31/551 , C07D213/75
CPC分类号： A61K31/35 , A61K31/44 , C07D401/12 , Y10S514/913
摘要： Methods for using hydroxyamino- and amino-substituted pyridine analogs are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of hydroxyamino- and amino-substituted pyridine analogs, are disclosed herein.
摘要翻译： 本文公开了使用羟基氨基 - 和氨基取代的吡啶类似物的方法来治疗rho激酶介导的疾病或rho激酶介导的病症，包括控制眼内压和治疗青光眼。 用于治疗眼部疾病例如青光眼并且还可用于控制眼内压的眼用药物组合物，本文公开了包含有效量的羟基氨基和氨基取代的吡啶类似物的组合物。
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9.发明申请BRADYKININ RECEPTOR AGONISTS AND USES THEREOF TO TREAT OCULAR HYPERTENSION AND GLAUCOMA 审中-公开BRADYKININ受体激动剂及其用于治疗高血压和GLAUCOMA的用途公开(公告)号：US20120283260A1
公开(公告)日：2012-11-08
申请号：US13556670
申请日：2012-07-24
申请人： Keith D. Combrink , Suchismita Mohapatra , Mark R. Hellberg , Najam A. Sharif , Ganesh Prasanna , Iok-Hou Pang , Bryon Severns , Hwang-Hsing Chen , Abdelmoula Namil
发明人： Keith D. Combrink , Suchismita Mohapatra , Mark R. Hellberg , Najam A. Sharif , Ganesh Prasanna , Iok-Hou Pang , Bryon Severns , Hwang-Hsing Chen , Abdelmoula Namil
IPC分类号： A61K31/4439 , C07D401/14 , A61K31/444 , C07D498/04 , A61K31/496 , A61K31/4545 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D471/04 , C07D401/12 , A61K31/4709 , C07D403/04 , A61K31/4184 , A61P27/02 , A61P27/06 , A61P9/12 , C07D401/06
CPC分类号： C07D401/14 , C07D401/06 , C07D401/12 , C07D403/06 , C07D413/14 , C07D498/04
摘要： The invention provides compositions and methods for treating and/or preventing ocular disorders associated with increased intraocular pressure. In particular, the compounds are bradykinin agonists.
摘要翻译： 本发明提供用于治疗和/或预防与增加的眼内压有关的眼部疾病的组合物和方法。 特别地，化合物是缓激肽激动剂。
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公开(公告)号：US20120046285A1
公开(公告)日：2012-02-23
申请号：US13211827
申请日：2011-08-17
申请人： Keith D. Combrink , Suchismita Mohapatra , Mark R. Hellberg , Najam A. Sharif , Ganesh Prasanna , Iok-Hou Pang , Bryon Severns , Hwang-Hsing Chen , Abdelmoula Namil
发明人： Keith D. Combrink , Suchismita Mohapatra , Mark R. Hellberg , Najam A. Sharif , Ganesh Prasanna , Iok-Hou Pang , Bryon Severns , Hwang-Hsing Chen , Abdelmoula Namil
IPC分类号： A61K31/5377 , C07D401/14 , C07D498/04 , C07D413/14 , A61P9/12 , A61K31/444 , A61K31/496 , A61K31/4545 , A61K31/506 , A61P27/06 , C07D401/06 , A61K31/4439
CPC分类号： C07D401/14 , C07D401/06 , C07D401/12 , C07D403/06 , C07D413/14 , C07D498/04
摘要： The invention provides compositions and methods for treating and/or preventing ocular disorders associated with increased intraocular pressure. In particular, the compounds are bradykinin agonists.
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