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1.发明申请公开(公告)号：US20110293562A1
公开(公告)日：2011-12-01
申请号：US13201431
申请日：2010-02-10
CPC分类号： A61K38/204 , A61K38/28
摘要： The invention is related to the use of cardiotrophin-1 (CT-1) for the treatment of obesity and associated disorders: hyperglycaemias, insulin resistance, development of type 2 diabetes and dyslipemias and given its anorexigenic role, fat oxidation stimulant, hypoglycaemic, sensitizing agent of the action of insulin on a skeletal muscle level and inhibitor of the intestinal transport of glucose by enterocytes.
摘要翻译： 本发明涉及心肌营养因子-1（CT-1）用于治疗肥胖症和相关疾病的用途：高血糖症，胰岛素抵抗，2型糖尿病和血脂异常的发展并给予其厌食症作用，脂肪氧化兴奋剂，低血糖，致敏 胰岛素对骨骼肌水平的作用的药剂和由肠细胞肠葡萄糖转运的抑制剂。
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公开(公告)号：US07732397B2
公开(公告)日：2010-06-08
申请号：US10798219
申请日：2004-03-11
申请人： Matilde Bustos De Abajo , Jesús Prieto Valtueña , Juan José Lasarte Sagastibelza , Elena Baixeras Llano
发明人： Matilde Bustos De Abajo , Jesús Prieto Valtueña , Juan José Lasarte Sagastibelza , Elena Baixeras Llano
CPC分类号： A61K38/19
摘要： Use of cardiotrophin in liver diseases. The invention describes the increased expression of cardiotrophin (CT-1) during the process of hepatic regeneration coinciding with maximum proliferation of hepatocytes and the role of CT-1 as a stimulator of hepatic regeneration. Furthermore, it describes the hepatoprotective role of CT-1 in various models of acute liver damage.The importance of using CT-1 in the manufacture of compositions for use in the treatment of hepatopathies is demonstrated. The invention describes such use in various forms and methods, including the recombinant protein and the use of the gene sequences that code for CT-1.
摘要翻译： 心肌营养蛋白在肝脏疾病中的应用 本发明描述了肝再生过程中心肌营养因子（CT-1）的表达增加与肝细胞的最大增殖和CT-1作为肝再生的刺激剂的作用。 此外，它描述了CT-1在各种急性肝损伤模型中的肝保护作用。 证明了使用CT-1制造用于治疗肝病的组合物的重要性。 本发明以各种形式和方法描述了这种用途，包括重组蛋白和使用编码CT-1的基因序列。
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