摘要:
The present invention is related to hybrid conjugates formed by covalently bonding siRNA (small interfering RNA) molecules to hydrophilic polymers for improving stability of the siRNA molecules effective for delivering the siRNA in vivo, and polyelectrolyte complex micelles formed by ionic interactions between the conjugates and multifunctional cationic compounds. The siRNA-hydrophilic polymer conjugates and polyelectrolyte complex micelles derived therefrom can be used for improving stability of the siRNA molecules in vivo. Consequently, the delivery of siRNA molecules for therapeutic applications into cells can be facilitated, and the siRNA is still active even though a small dose of the siRNA is used.
摘要:
Disclosed is a conjugate for gene transfer, which is capable of being used for treatment of incurable diseases, comprising an oligonucleotide intended to be transferred into target cells and a hydrophilic polymer, wherein an end of the oligonucleotide is covalently conjugated to the hydrophilic polymer. Also, the present invention discloses polyelectrolyte complex micelles formed from such a conjugate and a cationic polymer or cationic peptide. Such polyelectrolyte complex micelles can effectively transfer oligonucleotides as therapeutic agents into target cells, making it possible to obtain desired activities of the delivered oligonucleotides in target cells even when the micelles are clinically applied at a relatively low concentration. Therefore, the conjugate and the polyelectrolyte complex micelle are very useful in basic life science research and the medical field.
摘要:
A drum-type washing machine including at least one lifter for supplying wash water from the outside of a drum to the inside of the drum, and a controller for controlling water supply operations and washing operations based on the angle of rotation of the drum sensed by an angle sensing device. The controller positions the lifter under a water supply pipe so that the wash water is directly supplied from the outside of the drum to the inside of the drum through the lifter. Thus, laundry loaded in the drum is uniformly and rapidly wetted with the wash water. The controller also causes the laundry carried by the lifter to fall from the top position of the drum to maximize dropping power in a wash mode.
摘要:
A stacked organic light emitting device that includes an anode connected to an external power source, a cathode connected to the external power source, at least two light emitting sections aligned between the anode and the cathode, including a light emitting layer, and an internal electrode aligned between the light emitting sections. The internal electrode is a single-layered internal electrode which is made from one selected from the group consisting of a metal, alloys of the metal, and metal oxides thereof, having a work function below 4.5 eV, each light emitting section includes an organic material layer containing an organic material having an electron affinity above 4 eV, and the organic material layer is formed between the light emitting layer of the light emitting section and the electrode facing the anode connected to the external power source in two electrodes which make contact with the light emitting section.
摘要:
A washing machine and a control method thereof are provided, which control a rotational speed of a rotary tub (or revolutions per minute: RPM of a motor) according to a vibration level thereof to attenuate a vibration of the rotary tub. The washing machine includes the rotary tub, the motor, a vibration detecting unit and a control unit. The motor is linked to the rotary tub to be supplied with drive power and rotates the rotary tub. The vibration detecting unit detects the vibration level of the rotary tub using a variation of the drive power supplied to the motor when the motorrotates. The control unit controls a current rotational speed of the motor to be increased, maintained or decreased according to the vibration level of the rotary tub detected by the vibration detecting unit.
摘要:
A remote monitoring device for a laundry machine is disclosed. The remote monitoring device for a laundry machine includes a case for defining an exterior thereof, a communication modem board provided within the case for transmitting/receiving data with a laundry machine performing washing and drying to control the laundry machine, a display window for displaying a condition of the laundry machine operation, a first mounting part provided on a rear surface of the case, and a stand installed in a remote place from the laundry machine for fastening the first mounting part thereto. An object of the present invention is to provide a remote monitoring device for a laundry machine which enables a user to recognize and control an operation condition of a laundry device at a remote place.
摘要:
Noise from fuel returning to a cylinder and from bubbles contained in the returning fuel is reduced by positioning a nozzle with a plurality of penetration holes, each with much less sectional area than a flow sectional area for returning fuel. The nozzle is also equipped with a guide section installed to change the proceeding direction of the fuel passing through the penetration holes and the fuel return valve.