公开(公告)号：US06534004B2

公开(公告)日：2003-03-18

申请号：US09752313

申请日：2000-12-28

申请人： Ji-Feng Chen ,  Kent Wika

发明人： Ji-Feng Chen ,  Kent Wika

IPC分类号： B01J1900

CPC分类号： A61L27/3691 ,  A01N1/00 ,  A01N1/02 ,  A01N1/0221 ,  A61L2/0094 ,  A61L2/08 ,  A61L2/20 ,  A61L2/206 ,  A61L27/36 ,  A61L27/3683 ,  A61L2202/21

摘要： A method that allows for dry storage of bioprosthetic devices comprising a tissue component is provided. The method comprises the steps of providing a device comprising a chemically cross-linked animal tissue component; treating the tissue component with an aqueous solution comprising a biocompatible, water soluble, organic molecule comprising a plurality of carbon atoms and a plurality of hydroxyl groups for a time sufficient to allow equilibration between the fluids in the interstices of the tissue component and the aqueous solution; and then sterilizing the treated tissue component using a sterilizing gas or ionizing radiation. The present invention also relates to an implantable tissue component that can be stored dry. The tissue component is chemically-fixed and comprises within the interstices thereof a dimensional stabilizer selected from the group consisting of a polyhydric alcohol and derivatives thereof, a water soluble carbohydrate, and a water soluble gum. The tissue component is disposed within the chamber of a package, the chamber being defined by one or more members formed from a material that is resistant to penetration by micro-organisms, particularly bacteria and fungi. The chamber and tissue component are sterile and essentially free of an aldehyde solution. Except for the liquids contained within the tissue component, the chamber is also essentially free of liquid.

摘要翻译： 提供允许包含组织成分的生物假体装置的干燥储存的方法。 该方法包括提供包括化学交联动物组织成分的装置的步骤; 用含有包含多个碳原子和多个羟基的生物相容的水溶性有机分子的水溶液处理组织成分足以允许组织组分和水溶液间隙中的流体之间的平衡的时间 ; 然后使用灭菌气体或电离辐射对经处理的组织组分进行灭菌。 本发明还涉及可以干燥储存的可植入组织成分。 组织组分是化学固定的，并且在其间隙内包含选自多元醇及其衍生物，水溶性碳水化合物和水溶性胶质的尺寸稳定剂。 组织部件设置在包装的腔室内，该腔室由一种或多种由能够被微生物特别是细菌和真菌穿透的材料形成的构件限定。 腔室和组织组分是无菌的，基本上不含醛溶液。 除了包含在组织部件内的液体之外，室也基本上没有液体。

公开(公告)号：US20080015546A1

公开(公告)日：2008-01-17

申请号：US11776149

申请日：2007-07-11

申请人： Jesus Casas ,  Adam Blakstvedt ,  Molly Schiltgen ,  Kent Wika ,  Gyongike Molnar

发明人： Jesus Casas ,  Adam Blakstvedt ,  Molly Schiltgen ,  Kent Wika ,  Gyongike Molnar

IPC分类号： A61M31/00

CPC分类号： A61K9/0019 ,  A61B5/0515 ,  A61B5/416 ,  A61K9/10 ,  A61K9/127 ,  A61K35/12 ,  A61K49/0461 ,  A61K49/0471 ,  A61K49/1896 ,  A61K51/1203 ,  A61K51/1234

摘要： The present invention relates to methods, kits, and compositions for safe and efficient delivery of a bioagent to a targeted area of an organ. The method comprises preparing a suspension comprising the bioagent, a contrast agent, and a vehicle, wherein said suspension has an osmolarity from about 270 mOsm to about 440 mOsm; and dispensing at least a portion of said suspension into the targeted area. The invention further provides a kit for delivering a bioagent into a targeted area of an organ comprising: a delivery device; a contrast agent; and a vehicle.

摘要翻译： 本发明涉及用于将生物剂安全有效地递送至器官的目标区域的方法，试剂盒和组合物。 该方法包括制备包含生物剂，造影剂和载体的悬浮液，其中所述悬浮液具有约270mOsm至约440mOsm的渗透压浓度; 以及将所述悬架的至少一部分分配到所述目标区域中。 本发明还提供了用于将生物体递送到器官的目标区域的试剂盒，其包括：递送装置; 造影剂 和车辆。