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1.发明申请Methods and Compositions for Correlating Genetic Markers with Prostate Cancer Risk 有权将遗传标记与前列腺癌风险相关的方法和组合公开(公告)号：US20140057795A1
公开(公告)日：2014-02-27
申请号：US13818602
申请日：2011-09-02
申请人： Jianfeng Xu , Siqun Lilly Zheng , Jielin Sun , Andrew Karim Kader
发明人： Jianfeng Xu , Siqun Lilly Zheng , Jielin Sun , Andrew Karim Kader
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides methods of assessing an individual subject's risk of developing prostate cancer, comprising: a) analyzing a nucleic acid sample obtained from the subject and determining a genotype for the subject at a plurality of biallelic polymorphic loci, wherein each of said plurality has an associated allele and an unassociated allele, wherein the genotype is selected from the group consisting of homozygous for the associated allele, heterozygous, and homozygous for the unassociated allele; and b) calculating a cumulative relative risk (CRR) for the subject based on the genotype determined in step (a). A CRR of greater than 1.00 identifies a subject as having an increased risk of developing prostate cancer and also can identify a subject who is a candidate for early PSA screening, prostate biopsy and/or chemoprevention.
摘要翻译： 本发明提供了评估个体受试者发展前列腺癌风险的方法，包括：a）分析从受试者获得的核酸样品，并在多个双向多态位点确定受试者的基因型，其中所述多个基因座中的每一个具有 相关等位基因和非相关等位基因，其中所述基因型选自对于所述相关等位基因的相关等位基因纯合，杂合和纯合的基因型; 和b）基于步骤（a）中确定的基因型计算受试者的累积相对风险（CRR）。 大于1.00的CRR确定受试者具有发展前列腺癌的风险增加，并且还可以鉴定作为早期PSA筛选，前列腺活检和/或化学预防的候选者的受试者。
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公开(公告)号：US09732389B2
公开(公告)日：2017-08-15
申请号：US13818602
申请日：2011-09-02
申请人： Jianfeng Xu , Siqun Lilly Zheng , Jielin Sun , Andrew Karim Kader
发明人： Jianfeng Xu , Siqun Lilly Zheng , Jielin Sun , Andrew Karim Kader
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides methods of assessing an individual subject's risk of developing prostate cancer, comprising: a) analyzing a nucleic acid sample obtained from the subject and determining a genotype for the subject at a plurality of biallelic polymorphic loci, wherein each of said plurality has an associated allele and an unassociated allele, wherein the genotype is selected from the group consisting of homozygous for the associated allele, heterozygous, and homozygous for the unassociated allele; and b) calculating a cumulative relative risk (CRR) for the subject based on the genotype determined in step (a). A CRR of greater than 1.00 identifies a subject as having an increased risk of developing prostate cancer and also can identify a subject who is a candidate for early PSA screening, prostate biopsy and/or chemoprevention.
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3.发明申请TETHERED AND/OR VISUALLY CODED BRACHYTHERAPY DEVICES AND RELATED METHODS 有权方法和/或视觉编码的BRACHYTHERAPY设备及相关方法公开(公告)号：US20120065454A1
公开(公告)日：2012-03-15
申请号：US13197345
申请日：2011-08-03
CPC分类号： A61N5/1007 , A61B17/3468 , A61B90/92 , A61B2017/00274 , A61B2017/3411 , A61B2090/3987 , A61N5/1001 , A61N2005/1009 , A61N2005/1012 , A61N2005/1024 , Y10T29/49826
摘要： Bracytherapy devices include a respective tether attached to a proximal end portion of the strands. The tether can be color-coded to match a color associated with the corresponding strand.
摘要翻译： Bracytherapy装置包括连接到股线的近端部分的相应系绳。 系绳可以进行颜色编码以匹配与相应链条相关联的颜色。
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4.发明授权Tethered and/or visually coded brachytherapy devices and related methods 有权束缚和/或视觉编码的近距离放射治疗装置及相关方法公开(公告)号：US09272160B2
公开(公告)日：2016-03-01
申请号：US13197345
申请日：2011-08-03
CPC分类号： A61N5/1007 , A61B17/3468 , A61B90/92 , A61B2017/00274 , A61B2017/3411 , A61B2090/3987 , A61N5/1001 , A61N2005/1009 , A61N2005/1012 , A61N2005/1024 , Y10T29/49826
摘要： Bracytherapy devices include a respective tether attached to a proximal end portion of the strands. The tether can be color-coded to match a color associated with the corresponding strand.
摘要翻译： Bracytherapy装置包括连接到股线的近端部分的相应系绳。 系绳可以进行颜色编码以匹配与相应链条相关联的颜色。
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