公开(公告)号：US20180056266A1

公开(公告)日：2018-03-01

申请号：US15322672

申请日：2015-08-04

Applicant: Jiangnan University

Inventor： Zhengyu JIN ,  Yaoqi TIAN ,  Bao ZHANG ,  Han TAO ,  Benxi WEI ,  Xiuting HU ,  Chunsen WU ,  Xueming XU ,  Na YANG

IPC: B01J13/00 ,  C08L3/10 ,  C08L33/26

CPC classification number: B01J13/0065 ,  C08B31/18 ,  C08F2/32 ,  C08F220/54 ,  C08F222/38 ,  C08L3/02 ,  C08L3/10 ,  C08L33/26 ,  C08L2205/04

Abstract: The present disclosure discloses a triple-responsive starch-based microgel and a preparation method thereof. The present disclosure prepares C6 oxidized starch and PNIPAM semi-interpenetrating network microgel, namely the triple-responsive starch-based microgel, mainly with pH sensitive C6 oxidized starch and temperature sensitive NIPAM (N-isopropylacrylamide) as raw materials, and using an inverse emulsion polymerization method. The triple-responsive starch-based microgel according to the present disclosure is a spherical particle with the particle diameter of 15-25 μm, has pH, temperature and ionic strength-sensitivity, good biocompatibility and biodegradability, and can be widely used in the fields of nutrient protection, controlled drug release, protein separation and purification and the like. Meanwhile, its preparation process is simple and controllable with mild reaction conditions, and is suitable for large-scale production.