公开(公告)号：US20210002388A1

公开(公告)日：2021-01-07

申请号：US17004067

申请日：2020-08-27

申请人： Jiangnan University

发明人： Jian YIN ,  Jing HU ,  Juntao CAI

IPC分类号： C08B37/00 ,  C07H3/04 ,  C07H3/06 ,  C07H1/00 ,  C07H5/10 ,  C07H9/04 ,  C07H15/26

摘要： The present disclosure discloses a method for preparation of derivatives of gram-positive bacteria surface capsular polysaccharide, and belongs to the field of carbohydrate chemistry. The present disclosure takes glucose as a glycosyl donor to obtain a target β-glucosidic bond, then successfully synthesizes a disaccharide building block through a method of redox of a glucose C-2 site, and then takes the disaccharide building block as a repeat unit to synthesize a target oligosaccharide structure such as a derivative [→3)-α-D-Manp-(1→4)-β-D-Rhap-(1→]5-Linker of gram-positive bacteria cell wall capsular polysaccharide. A reduction end of decose is linked with a linker to be linked with a protein to make glycoconjugates for immunological studies. The method provided by the present disclosure is simple, time-saving, labor-saving and low-cost, and the resultant derivatives of the gram-positive bacteria surface capsular polysaccharide may be used for development and preparation of medicine related to autism.