公开(公告)号：US07557089B2

公开(公告)日：2009-07-07

申请号：US10541082

申请日：2003-12-31

申请人： Jianjun Zhang ,  Jiangong Shi ,  Yafang Wang ,  Dan Zhang ,  Mei Gao ,  Yongchun Yang ,  Shengyang Huang

发明人： Jianjun Zhang ,  Jiangong Shi ,  Yafang Wang ,  Dan Zhang ,  Mei Gao ,  Yongchun Yang ,  Shengyang Huang

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  C07H15/04

CPC分类号： A61K31/194 ,  A61K31/222 ,  A61K31/7012 ,  A61K31/7028

摘要： The use of extract form Wangla (coeloglossum viride (L) Hartm. Var. Bracteatum (Willd.) Richter), succinate derivative esters, and a derivative and pharmaceutical acceptable salts thereof, for the manufacture of a pharmaceutical preparation for the treatment of dementia, particularly for the treatment of Alzheimer' disease and Vascular dementia. Through Animal experiment, it has been demonstrated that, succinate derivative esters can improve learning and memory ability in dementia rats induced by scopolamine and cyclohexenyl imine; improve learning and memory ability in dementia rats induced by β-amyloid; improve learning and memory ability in dementia rats induced by permanent ligation of bilateral carotid; and improve memory ability of normal animals. It has the advantage of high activity, low toxicity and no inhibition to cholinesterase.

摘要翻译： 使用提取物形式用于制备用于治疗痴呆症的药物制剂的王of提取物（枸杞子（L）Hartm .V.B.Barleumum（Willd。）Richter），琥珀酸酯衍生物酯及其衍生物和药学上可接受的盐， 特别是用于治疗阿尔茨海默病和血管性痴呆。 通过动物实验，已经证明，琥珀酸衍生物酯可以改善由东莨菪碱和环己烯基亚胺诱导的痴呆大鼠的学习和记忆能力; 提高由β-淀粉样蛋白诱导的痴呆大鼠的学习和记忆能力; 提高双侧颈动脉永久性结扎引起的痴呆大鼠的学习记忆能力; 并提高正常动物的记忆能力。 具有活性高，毒性低，对胆碱酯酶无抑制作用。

公开(公告)号：US20060281692A1

公开(公告)日：2006-12-14

申请号：US10541082

申请日：2003-12-31

申请人： Jianjun Zhang ,  Jiangong Shi ,  Yafang Wang ,  Dan Zhang ,  Mei Gao ,  Yongchun Yang

发明人： Jianjun Zhang ,  Jiangong Shi ,  Yafang Wang ,  Dan Zhang ,  Mei Gao ,  Yongchun Yang

IPC分类号： A61K31/7034 ,  C07H15/04

CPC分类号： A61K31/194 ,  A61K31/222 ,  A61K31/7012 ,  A61K31/7028

摘要： The use of extract form Wangla (coeloglossum viride (L) Hartm. Var. Bracteatum (Willd.) Richter), succinate derivative esters, and a derivative and pharmaceutical acceptable salts thereof, for the manufacture of a pharmaceutical preparation for the treatment of dementia, particularly for the treatment of Alzheimer' disease and Vascular dementia. Through Animal experiment, it has been demonstrated that, succinate derivative esters can improve learning and memory ability in dementia rats induced by scopolamine and cyclohexenyl imine; improve learning and memory ability in dementia rats induced by β-amyloid; improve learning and memory ability in dementia rats induced by permanent ligation of bilateral carotid; and improve memory ability of normal animals. It has the advantage of high activity, low toxicity and no inhibition to cholinesterase.

公开(公告)号：US10174033B2

公开(公告)日：2019-01-08

申请号：US13515152

申请日：2009-12-10

申请人： Jiangong Shi ,  Jianjun Zhang ,  Zhenggang Yue ,  Min Li ,  Chenggen Zhu ,  Ying Zhang ,  Jiachen Zi ,  Yafang Wang ,  Xiaona Fan ,  Ruiming Xu ,  Sheng Lin ,  Yan Li ,  Yongchun Yang ,  Li Sheng

发明人： Jiangong Shi ,  Jianjun Zhang ,  Zhenggang Yue ,  Min Li ,  Chenggen Zhu ,  Ying Zhang ,  Jiachen Zi ,  Yafang Wang ,  Xiaona Fan ,  Ruiming Xu ,  Sheng Lin ,  Yan Li ,  Yongchun Yang ,  Li Sheng

IPC分类号： C07D473/34 ,  C07H19/167

摘要： The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.

公开(公告)号：US20130045942A1

公开(公告)日：2013-02-21

申请号：US13515152

申请日：2009-12-10

申请人： Jiangong Shi ,  Jianjun Zhang ,  Zhenggang Yue ,  Min Li ,  Chenggen Zhu ,  Ying Zhang ,  Jiachen Zi ,  Yafang Wang ,  Xiaona Fan ,  Ruiming Xu ,  Sheng Lin ,  Yan Li ,  Yongchun Yang ,  Li Sheng

发明人： Jiangong Shi ,  Jianjun Zhang ,  Zhenggang Yue ,  Min Li ,  Chenggen Zhu ,  Ying Zhang ,  Jiachen Zi ,  Yafang Wang ,  Xiaona Fan ,  Ruiming Xu ,  Sheng Lin ,  Yan Li ,  Yongchun Yang ,  Li Sheng

IPC分类号： A61K31/7076 ,  C07D473/34 ,  A61P25/28 ,  A61P25/08 ,  A61P25/16 ,  C07H19/167 ,  A61P25/20

CPC分类号： C07D473/34 ,  C07H19/167

摘要： The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.

摘要翻译： 本发明提供了N6取代的腺苷衍生物和N6-取代的腺嘌呤衍生物，其制备方法，包含上述化合物的药物组合物，以及这些化合物在制备用于治疗失眠，抽搐，癫痫的药物和保健产品中的用途， 和帕金森病，以及预防和治疗痴呆症。