Method of purifying a salt, sodium salt and disodium salt of pemetrexed
    1.
    发明授权
    Method of purifying a salt, sodium salt and disodium salt of pemetrexed 有权
    培美曲塞的盐,钠盐和二钠盐的纯化方法

    公开(公告)号:US08686140B2

    公开(公告)日:2014-04-01

    申请号:US12739576

    申请日:2008-10-21

    IPC分类号: C07D487/04

    CPC分类号: C07D487/04

    摘要: A method of purifying a salt of pemetrexed having a structure of formula (III) by salting-out, wherein if M3+ is H+, then each of M1+ and M2+ is independently H+, Li+, Na+ or K+, provided that both of them are not H+; if M3+ is Li+, Na+ or K+, then each of M1+ and M2+ is independently Li+, Na+ or K+.

    摘要翻译: 通过盐析纯化具有式(III)结构的培美曲塞盐的方法,其中如果M3 +为H +,则M1 +和M2 +各自独立地为H +,Li +,Na +或K +,条件是它们都不是 H +; 如果M3 +为Li +,Na +或K +,则M1 +和M2 +各自独立为Li +,Na +或K +。

    METHOD OF PURIFYING A SALT, SODIUM SALT AND DISODIUM SALT OF PEMETREXED
    2.
    发明申请
    METHOD OF PURIFYING A SALT, SODIUM SALT AND DISODIUM SALT OF PEMETREXED 有权
    盐酸盐,盐酸盐和盐酸盐的净化方法

    公开(公告)号:US20100305319A1

    公开(公告)日:2010-12-02

    申请号:US12739576

    申请日:2008-10-21

    IPC分类号: C07D487/04

    CPC分类号: C07D487/04

    摘要: A method of purifying a salt of pemetrexed have a structure of formula (III) by salting-out, wherein if M3+ is H+, then each of M1+ and M2+ is independently H+, Li+, Na+ or K+, provided that both of them are not H+; if M3+ is Li+, Na+ or K+, then each of M1+ and M2+ is independently Li+, Na+ or K+.

    摘要翻译: 纯化培美曲塞的盐的方法通过盐析得到式(III)的结构,其中如果M3 +是H +,则M1 +和M2 +各自独立地为H +,Li +,Na +或K +,条件是它们都不是 H +; 如果M3 +为Li +,Na +或K +,则M1 +和M2 +各自独立为Li +,Na +或K +。