Method of purifying a salt, sodium salt and disodium salt of pemetrexed
    1.
    发明授权
    Method of purifying a salt, sodium salt and disodium salt of pemetrexed 有权
    培美曲塞的盐,钠盐和二钠盐的纯化方法

    公开(公告)号:US08686140B2

    公开(公告)日:2014-04-01

    申请号:US12739576

    申请日:2008-10-21

    IPC分类号: C07D487/04

    CPC分类号: C07D487/04

    摘要: A method of purifying a salt of pemetrexed having a structure of formula (III) by salting-out, wherein if M3+ is H+, then each of M1+ and M2+ is independently H+, Li+, Na+ or K+, provided that both of them are not H+; if M3+ is Li+, Na+ or K+, then each of M1+ and M2+ is independently Li+, Na+ or K+.

    摘要翻译: 通过盐析纯化具有式(III)结构的培美曲塞盐的方法,其中如果M3 +为H +,则M1 +和M2 +各自独立地为H +,Li +,Na +或K +,条件是它们都不是 H +; 如果M3 +为Li +,Na +或K +,则M1 +和M2 +各自独立为Li +,Na +或K +。

    METHOD OF PURIFYING A SALT, SODIUM SALT AND DISODIUM SALT OF PEMETREXED
    2.
    发明申请
    METHOD OF PURIFYING A SALT, SODIUM SALT AND DISODIUM SALT OF PEMETREXED 有权
    盐酸盐,盐酸盐和盐酸盐的净化方法

    公开(公告)号:US20100305319A1

    公开(公告)日:2010-12-02

    申请号:US12739576

    申请日:2008-10-21

    IPC分类号: C07D487/04

    CPC分类号: C07D487/04

    摘要: A method of purifying a salt of pemetrexed have a structure of formula (III) by salting-out, wherein if M3+ is H+, then each of M1+ and M2+ is independently H+, Li+, Na+ or K+, provided that both of them are not H+; if M3+ is Li+, Na+ or K+, then each of M1+ and M2+ is independently Li+, Na+ or K+.

    摘要翻译: 纯化培美曲塞的盐的方法通过盐析得到式(III)的结构,其中如果M3 +是H +,则M1 +和M2 +各自独立地为H +,Li +,Na +或K +,条件是它们都不是 H +; 如果M3 +为Li +,Na +或K +,则M1 +和M2 +各自独立为Li +,Na +或K +。

    Morphinan derivatives and preparation methods thereof
    3.
    发明授权
    Morphinan derivatives and preparation methods thereof 失效
    吗啡喃衍生物及其制备方法

    公开(公告)号:US08563721B2

    公开(公告)日:2013-10-22

    申请号:US13000200

    申请日:2009-06-19

    IPC分类号: C07F7/02 C07D489/08

    CPC分类号: C07D489/08 C07D489/09

    摘要: The present invention relates to morphinan derivatives and preparation methods thereof, especially to ketal hydroxyl protected compounds of morphinan derivatives and preparation method thereof, and to a method for preparing corresponding alkylated morphinan derivatives by using the ketal hydroxyl protected compounds as intermediates, and more especially to a ketal hydroxyl protected compound of methylnaltrexone as intermediate for preparing methylnaltrexone and a method for preparing methylnaltrexone through said intermediate.

    摘要翻译: 本发明涉及吗啡喃衍生物及其制备方法,尤其涉及缩酮羟基保护的吗啡喃衍生物化合物及其制备方法,以及通过使用缩酮羟基保护的化合物作为中间体制备相应的烷基化吗啡喃衍生物的方法,更具体地涉及 作为制备甲基纳曲酮的中间体的甲基纳曲酮的缩酮羟基保护的化合物和通过所述中间体制备甲基纳曲酮的方法。

    MORPHINAN DERIVATIVES AND PREPARATION METHODS THEREOF
    4.
    发明申请
    MORPHINAN DERIVATIVES AND PREPARATION METHODS THEREOF 失效
    莫宁衍生物及其制备方法

    公开(公告)号:US20110112297A1

    公开(公告)日:2011-05-12

    申请号:US13000200

    申请日:2009-06-19

    IPC分类号: C07D489/08 C07F7/18

    CPC分类号: C07D489/08 C07D489/09

    摘要: The present invention relates to morphinan derivatives and preparation methods thereof, especially to ketal hydroxyl protected compounds of morphinan derivatives and preparation method thereof, and to a method for preparing corresponding alkylated morphinan derivatives by using the ketal hydroxyl protected compounds as intermediates, and more especially to a ketal hydroxyl protected compound of methylnaltrexone as intermediate for preparing methylnaltrexone and a method for preparing methylnaltrexone through said intermediate.

    摘要翻译: 本发明涉及吗啡喃衍生物及其制备方法,尤其涉及缩酮羟基保护的吗啡喃衍生物化合物及其制备方法,以及通过使用缩酮羟基保护的化合物作为中间体制备相应的烷基化吗啡喃衍生物的方法,更具体地涉及 作为制备甲基纳曲酮的中间体的甲基纳曲酮的缩酮羟基保护的化合物和通过所述中间体制备甲基纳曲酮的方法。

    FIBER BRAGG GRATING (FBG) SENSOR
    5.
    发明申请
    FIBER BRAGG GRATING (FBG) SENSOR 有权
    光纤光栅(FBG)传感器

    公开(公告)号:US20140119687A1

    公开(公告)日:2014-05-01

    申请号:US14115507

    申请日:2012-05-04

    IPC分类号: G02B6/34 G01L1/24

    摘要: A fiber Bragg grating (FBG) sensor structure, a method of fabricating a FBG sensor structure, and a method of employing a FBG sensor structure comprising an optical fiber portion having at least one FBG formed therein. The FBG sensor structure comprises an optical fiber portion having at least one FBG formed therein; and a sleeve structure capable of transferring vibrations and/or strain along a length thereof; wherein the optical fiber portion is coupled to the sleeve structure such that the central wavelength of the FBG, is variable under the transferred vibrations and/or strain.

    摘要翻译: 光纤布拉格光栅(FBG)传感器结构,FBG传感器结构的制造方法以及采用FBG传感器结构的方法,所述FBG传感器结构包括其中形成有至少一个FBG的光纤部分。 FBG传感器结构包括其中形成有至少一个FBG的光纤部分; 以及能够沿其长度传递振动和/或应变的套筒结构; 其中光纤部分耦合到套筒结构,使得FBG的中心波长在转移的振动和/或应变下是可变的。

    Channel condition dependent scheduling
    6.
    发明授权
    Channel condition dependent scheduling 有权
    通道条件相关调度

    公开(公告)号:US08542642B2

    公开(公告)日:2013-09-24

    申请号:US12997096

    申请日:2008-06-26

    申请人: Bo Lin Wim Rouwet

    发明人: Bo Lin Wim Rouwet

    IPC分类号: H04W72/10 H04W72/12 H04L12/26

    CPC分类号: H04W4/20

    摘要: An apparatus for data traffic scheduling comprises a scheduler assigning at least one priority parameter value prioritizing usage of a communication resource comprising a plurality of logical channels, to each of a plurality of users of the communication resource, a channel analyzer providing at least one channel condition indicator for each logical channel, and a filter providing a scheduling parameter value for each logical channel to the scheduler determining the priority parameter value, the scheduling parameter value being a weighted average of a plurality of values of the at least one channel condition indicator.

    摘要翻译: 一种用于数据业务调度的装置包括调度器,其向通信资源的多个用户中的每一个分配分配包括多个逻辑信道的通信资源的使用优先权的至少一个优先级参数值,信道分析器提供至少一个信道条件 指示符,以及向确定优先级参数值的调度器提供每个逻辑信道的调度参数值的过滤器,调度参数值是至少一个信道条件指示符的多个值的加权平均值。

    Packet based data cell delineation
    8.
    发明授权
    Packet based data cell delineation 有权
    基于数据包的数据单元描述

    公开(公告)号:US08194528B2

    公开(公告)日:2012-06-05

    申请号:US12532769

    申请日:2007-03-26

    IPC分类号: H04L12/26

    CPC分类号: H04L12/5601 H04L12/5602

    摘要: A method of delineation of a packet-based data stream in order to identify a boundary between neighbouring packets in the data stream, wherein the data stream comprises a predetermined number of bits (N); the method comprising the steps of: processing the data stream to search for the boundary between neighbouring packets in the data stream; characterised in that the method further comprises calculating the greatest common divisor (GCD) of a bit skip integer (n) where (N) and (n) are co-primes; iteratively checking after each n bits to identify the boundary between the neighbouring packets.

    摘要翻译: 一种描述基于分组的数据流以便识别数据流中的相邻分组之间的边界的方法,其中所述数据流包括预定数量的比特(N); 该方法包括以下步骤:处理数据流以搜索数据流中相邻分组之间的边界; 其特征在于,所述方法进一步包括:其中(N)和(n)是协同素数的比特跳过整数(n)的最大公约数(GCD) 在每个n位之后迭代地检查以识别相邻分组之间的边界。