公开(公告)号：US06488959B2

公开(公告)日：2002-12-03

申请号：US09864472

申请日：2001-05-24

申请人： Theodore Stanley ,  Wade Hull ,  Larry Rigby ,  Jie Zhang

发明人： Theodore Stanley ,  Wade Hull ,  Larry Rigby ,  Jie Zhang

IPC分类号： A61F1300

CPC分类号： A61K9/7084 ,  A61N1/30

摘要： The present invention relates to a transdermal drug delivery system comprising a dermal drug delivery patch and a heating element compartment securable to the dermal drug delivery patch. A freely transferrable heating element is securable within the heating element compartment. A drug can be administered transdermally using the present invention by placing the dermal drug delivery patch upon a patient's skin at an administration site. A heating element compartment is secured to the dermal drug delivery patch and a freely transferrable heating element is placed within the heating element compartment. The heating element provides controlled heat to the dermal drug patch and the patient's skin and thereby improves dermal drug administration.

公开(公告)号：US06756053B2

公开(公告)日：2004-06-29

申请号：US09878558

申请日：2001-06-11

申请人： Jie Zhang ,  Wade Hull ,  Larry Rigby

发明人： Jie Zhang ,  Wade Hull ,  Larry Rigby

IPC分类号： A61K970

CPC分类号： A61K9/0024 ,  A61B2017/00765 ,  A61F7/02 ,  A61F7/032 ,  A61F7/034 ,  A61F2013/00187 ,  A61F2013/00204 ,  A61F2013/00906 ,  A61F2013/0091 ,  A61K9/0009 ,  A61K9/7023 ,  A61K31/4468 ,  A61K31/4535 ,  A61M31/002 ,  A61M37/00 ,  A61M2037/0007 ,  A61N1/30

摘要： The present invention is directed to a method and system for delivering a drug into the systemic circulation. The method comprises establishing a drug depot in a patient's skin and/or sub-skin tissues by applying a transdermal drug delivery system on the patients skin, for a predetermined time so that a drug depot is formed in said user's skin and/or sub-skin tissues. A heating source is placed proximate to the skin area to rapidly release a bolus of the drug from the depot into the systemic circulation when there is a need to rapidly increase the drug's concentrations in the systemic circulation.

摘要翻译： 本发明涉及一种将药物输送到体循环中的方法和系统。 该方法包括通过在患者皮肤上施用透皮药物递送系统在患者皮肤和/或亚皮肤组织中建立药物库，预定时间，使得在所述使用者的皮肤和/或子部分中形成药物库， 皮肤组织。 当需要快速增加药物在体循环中的浓度时，将加热源放置在皮肤区域附近，以迅速将药物从药剂释放到体循环中。

公开(公告)号：US07094228B2

公开(公告)日：2006-08-22

申请号：US10208662

申请日：2002-07-30

申请人： Jie Zhang ,  Larry Rigby ,  Wade Hull

发明人： Jie Zhang ,  Larry Rigby ,  Wade Hull

IPC分类号： A61M31/00

CPC分类号： A61M31/002 ,  A61M2037/0007 ,  A61M2205/36 ,  A61N5/062

摘要： An apparatus to rapidly deliver a drug to a patient, the invention comprising the method of locating a drug beneath a patient's skin in a drug depot site, placing a heating component near the drug depot site and generating heat in and near the drug depot site. A control component connected to the heating component is used to control the magnitude and duration of heat generated by the heating component.

公开(公告)号：US06955819B2

公开(公告)日：2005-10-18

申请号：US09796250

申请日：2001-02-28

申请人： Jie Zhang ,  Wade Hull ,  Larry Rigby ,  Theodore Stanley

发明人： Jie Zhang ,  Wade Hull ,  Larry Rigby ,  Theodore Stanley

IPC分类号： A61F7/03 ,  A61F13/00 ,  A61K9/00 ,  A61K9/70 ,  A61M31/00 ,  A61N1/30

CPC分类号： A61K9/0024 ,  A61F7/032 ,  A61F2013/00646 ,  A61K9/0004 ,  A61K9/0009 ,  A61K9/703 ,  A61M31/002 ,  A61M2037/0007 ,  A61N1/30

摘要： The present invention is directed toward an apparatus to rapidly deliver a drug to a patient The invention comprises a drug beneath a patient's skin in a drug depot site. A heating component is placed near the drug depot site and generates heat in and near the drug depot site. A control component connected to the heating component is used to control the magnitude and duration of heat generated by the heating component.

摘要翻译： 本发明涉及一种将药物快速输送给患者的装置。本发明包括在药物库位点的患者皮肤下面的药物。 加热部件放置在药物库位附近，并在药物库位置内和附近产生热量。 连接到加热部件的控制部件用于控制由加热部件产生的热量的大小和持续时间。

公开(公告)号：US06261595B1

公开(公告)日：2001-07-17

申请号：US09515722

申请日：2000-02-29

申请人： Theodore Stanley ,  Wade Hull ,  Larry Rigby

发明人： Theodore Stanley ,  Wade Hull ,  Larry Rigby

IPC分类号： A61F1300

CPC分类号： A61K9/7084 ,  A61N1/30

摘要： The present invention relates to a transdermal drug delivery system comprising a dermal drug delivery patch and a heating element compartment securable to the dermal drug delivery patch. A freely transferrable heating element is securable within the heating element compartment. A drug can be administered transdermally using the present invention by placing the dermal drug delivery patch upon a patient's skin at an administration site. A heating element compartment is secured to the dermal drug delivery patch and a freely transferrable heating element is placed within the heating element compartment. The heating element provides controlled heat to the dermal drug patch and the patient's skin aid thereby improves dermal drug administration.

摘要翻译： 本发明涉及一种透皮药物递送系统，其包括皮肤药物递送贴片和可固化至真皮药物递送贴剂的加热元件隔室。 可自由传递的加热元件可在加热元件隔室内固定。 可以通过将皮肤药物递送贴片放置在给药部位的患者皮肤上，通过本发明透皮给药。 加热元件隔室被固定到皮肤药物递送贴片上，并且将可自由转移的加热元件放置在加热元件隔室内。 加热元件为皮肤药物贴剂提供受控的热量，并且患者的皮肤助剂从而改善皮肤药物给药。

公开(公告)号：US11642356B2

公开(公告)日：2023-05-09

申请号：US16343690

申请日：2016-10-21

申请人： Wade Hull ,  Ngoc Truc-Chi Vo ,  Dominic King-Smith

发明人： Wade Hull ,  Ngoc Truc-Chi Vo ,  Dominic King-Smith

IPC分类号： A61K31/573 ,  A61K9/08 ,  A61K47/12 ,  A61K47/14 ,  A61P17/06 ,  A61K9/00

CPC分类号： A61K31/573 ,  A61K9/0014 ,  A61K9/08 ,  A61K47/12 ,  A61K47/14 ,  A61P17/06

摘要： In one example presented herein, is a pharmaceutical composition. The pharmaceutical composition can include halobetasol propionate, from 0 wt % to 3 wt % ethoxylated castor oil, a first compound, and a second compound. The first compound and the second compound can be selected from; N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate, and sodium lauryl sulfoacetate. The first compound and the second compound are not the same.