公开(公告)号：US20100028359A1

公开(公告)日：2010-02-04

申请号：US12437715

申请日：2009-05-08

申请人： Jijie GU ,  Chung-Ming HSIEH ,  Zhen WU ,  Enrico L. DiGIAMMARINO ,  Feng LUO ,  Gerard B. FOX ,  John E. HARLAN ,  Martin SCHMIDT ,  Ralf LOEBBERT ,  Reinhold MUELLER ,  Ulrich EBERT ,  Volker NIMMRICH

发明人： Jijie GU ,  Chung-Ming HSIEH ,  Zhen WU ,  Enrico L. DiGIAMMARINO ,  Feng LUO ,  Gerard B. FOX ,  John E. HARLAN ,  Martin SCHMIDT ,  Ralf LOEBBERT ,  Reinhold MUELLER ,  Ulrich EBERT ,  Volker NIMMRICH

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K16/00 ,  A61P25/28 ,  C12N15/63 ,  C12N5/10 ,  C12P21/02

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/464 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C12P21/005 ,  Y02A50/466

摘要： The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example misfolded proteins like amyloid B and advanced glycation-end-products.

摘要翻译： 本申请涉及分离的蛋白质，特别是单克隆抗体，特别是结合RAGE蛋白质的CDR-移植的人源化抗体。 具体地说，这些抗体具有抑制RAGE与其各种配体结合的能力。 本申请中描述的抗体或其部分可用于治疗由RAGE的病理生理学配体表征或诱导的疾病或病症，例如错误折叠的蛋白质，如淀粉样蛋白B和晚期糖基化终产物。

公开(公告)号：US20100308814A1

公开(公告)日：2010-12-09

申请号：US12749498

申请日：2010-03-29

申请人： Zhen WU

发明人： Zhen WU

IPC分类号： G01R33/02

CPC分类号： G01R33/032 ,  A61B5/04008

摘要： The present invention relates to a method and system for high spatial resolution measurement of a magnetic field or gradient. The method determines Zeeman polarization at a submicron distance from cell surfaces of an optical pumping cell using two laser beams. A strong pump beam produces Zeeman polarization in the vicinity of surfaces inside the optical pumping cell. The Zeeman polarization precesses around the magnetic field that is to be measured and is probed by the evanescent wave of a weak probe beam. The precessing Zeeman polarization can be monitored by measuring reflectivity of the probe beam at an interface between the active medium and the cell. The polarization can be used to measure the magnetic field or gradient. In one embodiment a second probe beam in the yz-plane is incident on the same position as the pump beam and the first probe beam that is in the xz-plane. Both probe beams undergo total internal reflection at an interface between the cell surface and the active medium. The reflectivities of the two probe beams are measured, from which the x, y and z components of the magnetic field can be determined simultaneously.

摘要翻译： 本发明涉及用于磁场或梯度的高空间分辨率测量的方法和系统。 该方法使用两个激光束确定与光泵浦单元的单元表面亚微米距离的塞曼极化。 强泵浦光束在光泵浦单元内的表面附近产生塞曼极化。 塞曼极化围绕要测量的磁场进行，并由弱探针光束的ev逝波探测。 可以通过测量探针光束在活性介质和电池之间的界面处的反射率来监测进动中塞曼极化。 极化可用于测量磁场或梯度。 在一个实施例中，yz平面中的第二探测光束入射在与泵浦光束和位于xz平面中的第一探测光束相同的位置上。 两个探针光束在单元表面和活性介质之间的界面处经历全内反射。 测量两个探测光束的反射率，可同时确定磁场的x，y和z分量。

公开(公告)号：US20120182220A1

公开(公告)日：2012-07-19

申请号：US13353811

申请日：2012-01-19

申请人： Zhen WU

发明人： Zhen WU

IPC分类号： G06F3/02 ,  G06F3/041

CPC分类号： G06F3/04886 ,  G06F3/018 ,  G06F3/0236

摘要： A mobile terminal and a method of character entry, wherein the mobile terminal includes a keypad keys that receive a first input, wherein the keys correspond to characters; a display; and a processor that receives the first input through a key of the keypad, controls the display to display a level key that includes a set of characters corresponding to the key and displays each character of the set of characters in separate areas, where the separate areas correspond to the plurality of keys of the keypad, receives a second input through one of keys, and controls the display to display a character from the set of characters of the level key corresponding to the second input, as a character entry.

摘要翻译： 一种移动终端和字符输入方法，其中所述移动终端包括接收第一输入的键区键，其中所述键对应于字符; 一个显示器 以及处理器，其通过键盘的键接收第一输入，控制显示器以显示包括与该键对应的一组字符的级别键，并将该组字符的每个字符显示在分开的区域中， 对应于键盘的多个键，通过其中一个键接收第二输入，并且控制显示器以从与第二输入相对应的电平键的字符集中显示字符作为字符条目。