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    Mass Separation Method of Magnolol from Magnoliae Cortex Radix
    2.
    发明申请
    Mass Separation Method of Magnolol from Magnoliae Cortex Radix 有权
    木兰木兰的大分离方法

    公开(公告)号：US20080188693A1

    公开(公告)日：2008-08-07

    申请号：US11915721

    申请日：2005-06-21

    申请人： Jin Sook Kim ,  Yun Mi Lee ,  Dae Sik Jang

    发明人： Jin Sook Kim ,  Yun Mi Lee ,  Dae Sik Jang

    IPC分类号： C07C39/15

    CPC分类号： C07C37/82 ,  C07C37/004 ,  C07C37/685 ,  C07C37/84 ,  C07C39/21

    摘要： The present invention related to method for the mass separation of magnolol from Magnoliae cortex or Magnoliae radix. The method comprises the steps of: 1) crushing Magnoliae cortex or Magnoliae radix, extracting the crushed material with organic solvent, adding n-hexane to the extract so as to obtain a n-hexane layer; 2) concentrating the n-hexane layer in a water bath at a temperature of 30-40 ° C. and a revolution speed of 40-200 RPM under reduced pressure so as to form a crude crystal; and 3) removing the n-hexane from the crude crystal, completely dissolving the crude crystal in chloroform, adding n-hexane to the n-hexane-containing solution, and leaving the solution to stand at room temperature so as to recrystallize the solution. In the method, a column chromatography step which is necessarily carried out in the general separation process is omitted so that separation process steps are reduced, leading to a saving in separation time. Also, expensive equipment is not required, leading a reduction in separation cost. Accordingly, the method is effective for the mass separation of expensive magnolol.

    摘要翻译： 本发明涉及厚朴与厚朴与木兰质量分离的方法。 该方法包括以下步骤：1）粉碎玉兰大麦或木兰，用有机溶剂萃取粉碎物，向提取液中加入正己烷，得到正己烷层; 2）将正己烷层在30-40℃的温度和40-200RPM的转速下在水浴中浓缩，以形成粗晶体; 3）从粗结晶中除去正己烷，将粗结晶完全溶解在氯仿中，向正己烷溶液中加入正己烷，使溶液在室温下静置，使溶液重结晶。 在该方法中，省略了在一般的分离过程中必须进行的柱色谱步骤，从而减少了分离工艺步骤，从而节省了分离时间。 此外，不需要昂贵的设备，导致分离成本的降低。 因此，该方法对于昂贵的厚朴酚的质量分离是有效的。

    Mass separation method of magnolol from Magnoliae cortex radix
    3.
    发明授权
    Mass separation method of magnolol from Magnoliae cortex radix 有权
    厚朴从大叶皮质素的质量分离方法

    公开(公告)号：US07608741B2

    公开(公告)日：2009-10-27

    申请号：US11915721

    申请日：2005-06-21

    申请人： Jin Sook Kim ,  Yun Mi Lee ,  Dae Sik Jang

    发明人： Jin Sook Kim ,  Yun Mi Lee ,  Dae Sik Jang

    IPC分类号： C07C39/12

    CPC分类号： C07C37/82 ,  C07C37/004 ,  C07C37/685 ,  C07C37/84 ,  C07C39/21

    摘要： The present invention related to method for the mass separation of magnolol from Magnoliae cortex or Magnoliae radix. The method comprises the steps of: 1) crushing Magnoliae cortex or Magnoliae radix, extracting the crushed material with organic solvent, adding n-hexane to the extract so as to obtain a n-hexane layer; 2) concentrating the n-hexane layer in a water bath at a temperature of 30-40° C. and a revolution speed of 40-200 RPM under reduced pressure so as to form a crude crystal; and 3) removing the n-hexane from the crude crystal, completely dissolving the crude crystal in chloroform, adding n-hexane to the n-hexane-containing solution, and leaving the solution to stand at room temperature so as to recrystallize the solution. In the method, a column chromatography step which is necessarily carried out in the general separation process is omitted so that separation process steps are reduced, leading to a saving in separation time. Also, expensive equipment is not required, leading a reduction in separation cost. Accordingly, the method is effective for the mass separation of expensive magnolol.

    摘要翻译： 本发明涉及厚朴与厚朴与木兰质量分离的方法。 该方法包括以下步骤：1）粉碎玉兰大麦或木兰，用有机溶剂萃取粉碎物，向提取液中加入正己烷，得到正己烷层; 2）将正己烷层在30-40℃的温度和40-200RPM的转速下在水浴中浓缩，以形成粗晶体; 3）从粗结晶中除去正己烷，将粗结晶完全溶解在氯仿中，向正己烷溶液中加入正己烷，使溶液在室温下静置，使溶液重结晶。 在该方法中，省略了在一般的分离过程中必须进行的柱色谱步骤，从而减少了分离工艺步骤，从而节省了分离时间。 此外，不需要昂贵的设备，导致分离成本的降低。 因此，该方法对于昂贵的厚朴酚的质量分离是有效的。

    COMPOSITIONS AND FUNCTIONAL FOODS FOR TREATING AND PREVENTING OBESITY USING POLYGONUM CUSPIDATUM BUTANOL FRACTION AND ETHYL ACETATE FRACTION
    5.
    发明申请
    COMPOSITIONS AND FUNCTIONAL FOODS FOR TREATING AND PREVENTING OBESITY USING POLYGONUM CUSPIDATUM BUTANOL FRACTION AND ETHYL ACETATE FRACTION 有权
    组合物和功能性食品，用于处理和预防使用多酚丁醇脂肪酸酯和乙酸乙酯酯的成分

    公开(公告)号：US20120183633A1

    公开(公告)日：2012-07-19

    申请号：US13498247

    申请日：2009-12-29

    申请人： Jin Sook Kim ,  Dae Sik Jang ,  Young Sook Kim ,  Junghyun Kim ,  Chan-Sik Kim

    发明人： Jin Sook Kim ,  Dae Sik Jang ,  Young Sook Kim ,  Junghyun Kim ,  Chan-Sik Kim

    IPC分类号： A61K36/704 ,  A61P3/06 ,  A61P3/00 ,  A61P3/04

    CPC分类号： A61K36/704 ,  A23L33/105

    摘要： The present invention relates to the obesity-curative or obesity-preventive effect of a Polygonum cuspidatum butanol fraction and a Polygonum cuspidatum ethylacetate fraction, and more particularly, to a pharmaceutical composition and a functional food for treating obesity, the pharmaceutical composition and the functional food comprising a Polygonum cuspidatum butanol fraction (POCU-1b) and an ethylacetate fraction as active ingredients, wherein the Polygonum cuspidatum butanol fraction and the ethylacetate fraction inhibit effectively the activity of pancreatic lipase, an important enzyme involving in fat absorption in a living body, and have excellent inhibitory effect on fat absorption in the short term fat absorption-inhibitory animal experiments using lipid emulsions.

    摘要翻译： 本发明涉及枸杞子枸杞子和枸杞子乙酸乙酯级分的肥胖治疗或肥胖预防效果，更具体地说，涉及用于治疗肥胖症的药物组合物和功能性食品，药物组合物和功能性食品 包括枸杞子丁醇级分（POCU-1b）和乙酸乙酯级分作为活性成分，其中枸杞子丁醇级分和乙酸乙酯级分有效地抑制了胰脂肪酶的活性，胰脂肪酶是涉及活体脂肪吸收的重要酶， 在使用脂质乳剂的短期脂肪吸收抑制动物实验中对脂肪吸收具有优异的抑制作用。

    Compositions and functional foods for treating and preventing obesity using polygonum cuspidatum butanol fraction and ethyl acetate fraction
    6.
    发明授权
    Compositions and functional foods for treating and preventing obesity using polygonum cuspidatum butanol fraction and ethyl acetate fraction 有权
    用于治疗和预防肥胖的组合物和功能性食物，使用枸杞子丁醇部分和乙酸乙酯部分

    公开(公告)号：US09504725B2

    公开(公告)日：2016-11-29

    申请号：US13498247

    申请日：2009-12-29

    申请人： Jin Sook Kim ,  Dae Sik Jang ,  Young Sook Kim ,  Junghyun Kim ,  Chan-Sik Kim

    发明人： Jin Sook Kim ,  Dae Sik Jang ,  Young Sook Kim ,  Junghyun Kim ,  Chan-Sik Kim

    IPC分类号： A61K36/704

    CPC分类号： A61K36/704 ,  A23L33/105

    摘要： The present invention relates to the obesity-curative or obesity-preventive effect of a Polygonum cuspidatum butanol fraction and a Polygonum cuspidatum ethylacetate fraction, and more particularly, to a pharmaceutical composition and a functional food for treating obesity, the pharmaceutical composition and the functional food comprising a Polygonum cuspidatum butanol fraction (POCU-1b) and an ethylacetate fraction as active ingredients, wherein the Polygonum cuspidatum butanol fraction and the ethylacetate fraction inhibit effectively the activity of pancreatic lipase, an important enzyme involving in fat absorption in a living body, and have excellent inhibitory effect on fat absorption in the short term fat absorption-inhibitory animal experiments using lipid emulsions.

    摘要翻译： 本发明涉及枸杞子枸杞子和枸杞子乙酸乙酯级分的肥胖治疗或肥胖预防效果，更具体地说，涉及用于治疗肥胖症的药物组合物和功能性食品，药物组合物和功能性食品 包括枸杞子丁醇级分（POCU-1b）和乙酸乙酯级分作为活性成分，其中枸杞子丁醇级分和乙酸乙酯级分有效地抑制了胰脂肪酶的活性，胰脂肪酶是涉及活体脂肪吸收的重要酶， 在使用脂质乳剂的短期脂肪吸收抑制动物实验中对脂肪吸收具有优异的抑制作用。