公开(公告)号：US20110123439A1

公开(公告)日：2011-05-26

申请号：US12991503

申请日：2009-05-08

申请人： Jin Woo Cheon ,  Jin-Sil Choi ,  Jeongsoo Yoo ,  Jeong Chan Park ,  Yongmin Chang

发明人： Jin Woo Cheon ,  Jin-Sil Choi ,  Jeongsoo Yoo ,  Jeong Chan Park ,  Yongmin Chang

IPC分类号： A61K51/12

CPC分类号： A61K49/186 ,  A61K49/0002 ,  A61K49/1854 ,  A61K49/1857 ,  A61K49/1863 ,  A61K49/1869 ,  A61K49/1875 ,  A61K51/1255

摘要： The present invention relates a dual-modality PET (positron emission tomography)/MRI (magnetic resonance imaging) contrast agent, a hybrid nanoparticle comprising: (a) a magnetic signal generating core; (b) a water-soluble multi-functional ligand coated on the signal generating core; and (c) a positron emitting factor linked to the water-soluble multi-functional ligand. The contrast agent of the present invention is the dual-modality contrast agent enabling to perform PET and MR imaging and can effectively obtain images having the merits of PET (excellent sensitivity and high temporal resolution) and MR (high spatial resolution and anatomical information) imaging. The contrast agent of the present invention is very useful for non-invasive and highly sensitive real-time fault-free imaging of various biological events such as cell migration, diagnosis of various diseases (e.g., cancer diagnosis) and drug delivery.

摘要翻译： 本发明涉及双重模式PET（正电子发射断层摄影）/ MRI（磁共振成像）造影剂，混合纳米颗粒，其包括：（a）磁信号产生芯; （b）涂覆在信号产生芯上的水溶性多官能配体; 和（c）与水溶性多官能配体连接的正电子发射因子。 本发明的造影剂是能够进行PET和MR成像的双重模式对比剂，并且可以有效地获得具有PET优点（优异的灵敏度和高时间分辨率）和MR（高空间分辨率和解剖信息）成像的图像 。 本发明的造影剂对于诸如细胞迁移，各种疾病的诊断（例如癌症诊断）和药物递送的各种生物事件的非侵入性和高度灵敏度的实时无故障成像非常有用。

公开(公告)号：US20120276002A1

公开(公告)日：2012-11-01

申请号：US13503256

申请日：2010-10-22

申请人： Jeong Soo Yoo ,  Jeong Chan Park

发明人： Jeong Soo Yoo ,  Jeong Chan Park

IPC分类号： A61K51/10 ,  A61B1/06 ,  C07K16/18 ,  G01T1/164 ,  G01T1/20

CPC分类号： G01T1/164 ,  A61K49/0002 ,  A61K49/0067 ,  A61K49/1857 ,  A61K51/02 ,  A61K51/025 ,  A61K51/0491 ,  A61K51/1051 ,  A61K51/1244 ,  G01T1/2018 ,  G01T7/08

摘要： Provided are a contrast agent for optical imaging, a use thereof and an apparatus using the same.The contrast agent for optical imaging of the present disclosure allows optical imaging without requiring a fluorophore or a luminophore. As a result, the optical images can be acquired without changing the physicochemical properties of a substrate. The contrast agent for optical imaging of the present disclosure may be used as an optical/nuclear bimodal imaging contrast agent for many applications, and allows radiation therapy as well as monitoring of a therapeutic effect thereof through optical imaging at the same time. Further, when a fluorophore is attached thereto, light emission may be enhanced without energy input from outside since light is emitted from the fluorophore, thereby increasing luminescence intensity and improving tissue penetration.

摘要翻译： 提供了一种用于光学成像的造影剂，其用途和使用该造影剂的装置。 本公开的用于光学成像的造影剂允许光学成像，而不需要荧光团或发光体。 结果，可以在不改变基板的物理化学性质的情况下获取光学图像。 用于本公开的光学成像的造影剂可以用作许多应用的光/核双模式成像造影剂，并且允许放射治疗以及通过光学成像同时监测其治疗效果。 此外，当附着有荧光团时，由于从荧光团发出光，所以可以增强发光，而不会从外部输入能量，从而增加发光强度并改善组织穿透。