公开(公告)号：US20130011389A1

公开(公告)日：2013-01-10

申请号：US13327659

申请日：2011-12-15

申请人： Jin-An JIAO ,  Hing C. Wong ,  Jack O. Egan

发明人： Jin-An JIAO ,  Hing C. Wong ,  Jack O. Egan

IPC分类号： A61K39/395 ,  A61P11/00

CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55

摘要： Disclosed are methods for preventing or treating sepsis, a sepsis-related condition or an inflammatory disease in a mammal. In one embodiment, the method includes administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that binds specifically to tissue factor (TF) to form a complex in which factor X or factor IX binding to the complex is inhibited and the administration is sufficient to prevent or treat the sepsis in the mammal. The invention has a wide spectrum of useful applications including treating sepsis, disorders related to sepsis, and inflammatory diseases such as arthritis.

公开(公告)号：US20110182900A1

公开(公告)日：2011-07-28

申请号：US13013767

申请日：2011-01-25

申请人： Jin-An JIAO ,  Hing C. Wong ,  Jack O. Egan

发明人： Jin-An JIAO ,  Hing C. Wong ,  Jack O. Egan

IPC分类号： A61K39/395 ,  A61P11/00

CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55

摘要： Disclosed are methods for preventing or treating sepsis, a sepsis-related condition or an inflammatory disease in a mammal. In one embodiment, the method includes administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that binds specifically to tissue factor (TF) to form a complex in which factor X or factor IX binding to the complex is inhibited and the administration is sufficient to prevent or treat the sepsis in the mammal. The invention has a wide spectrum of useful applications including treating sepsis, disorders related to sepsis, and inflammatory diseases such as arthritis.

摘要翻译： 公开了用于预防或治疗哺乳动物中败血症，败血症相关病症或炎性疾病的方法。 在一个实施方案中，所述方法包括向哺乳动物施用治疗有效量的至少一种特异性结合组织因子（TF）的人源化抗体，嵌合抗体或其片段，以形成其中因子X或因子IX与 复合物被抑制，并且给药足以预防或治疗哺乳动物的败血症。 本发明具有广泛的有用应用，包括治疗败血症，与败血症有关的疾病，以及诸如关节炎的炎性疾病。

公开(公告)号：US20090136501A1

公开(公告)日：2009-05-28

申请号：US12036188

申请日：2008-02-22

申请人： Jin-An JIAO ,  Hing C. Wong ,  Jack O. Egan

发明人： Jin-An JIAO ,  Hing C. Wong ,  Jack O. Egan

IPC分类号： A61K39/395

CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55

摘要： Disclosed are methods for preventing or treating sepsis, a sepsis-related condition or an inflammatory disease in a mammal. In one embodiment, the method includes administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that binds specifically to tissue factor (TF) to form a complex in which factor X or factor IX binding to the complex is inhibited and the administration is sufficient to prevent or treat the sepsis in the mammal. The invention has a wide spectrum of useful applications including treating sepsis, disorders related to sepsis, and inflammatory diseases such as arthritis.

摘要翻译： 公开了用于预防或治疗哺乳动物中败血症，败血症相关病症或炎性疾病的方法。 在一个实施方案中，所述方法包括向哺乳动物施用治疗有效量的至少一种特异性结合组织因子（TF）的人源化抗体，嵌合抗体或其片段，以形成其中因子X或因子IX与 复合物被抑制，并且给药足以预防或治疗哺乳动物的败血症。 本发明具有广泛的有用应用，包括治疗败血症，与败血症有关的疾病，以及诸如关节炎的炎性疾病。