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    COMPOSITIONS AND METHODS FOR TREATING COAGULATION RELATED DISORDERS
    1.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING COAGULATION RELATED DISORDERS 审中-公开
    用于治疗凝血相关疾病的组合物和方法

    公开(公告)号：US20110182900A1

    公开(公告)日：2011-07-28

    申请号：US13013767

    申请日：2011-01-25

    申请人： Jin-An JIAO ,  Hing C. Wong ,  Jack O. Egan

    发明人： Jin-An JIAO ,  Hing C. Wong ,  Jack O. Egan

    IPC分类号： A61K39/395 ,  A61P11/00

    CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55

    摘要： Disclosed are methods for preventing or treating sepsis, a sepsis-related condition or an inflammatory disease in a mammal. In one embodiment, the method includes administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that binds specifically to tissue factor (TF) to form a complex in which factor X or factor IX binding to the complex is inhibited and the administration is sufficient to prevent or treat the sepsis in the mammal. The invention has a wide spectrum of useful applications including treating sepsis, disorders related to sepsis, and inflammatory diseases such as arthritis.

    摘要翻译： 公开了用于预防或治疗哺乳动物中败血症，败血症相关病症或炎性疾病的方法。 在一个实施方案中，所述方法包括向哺乳动物施用治疗有效量的至少一种特异性结合组织因子（TF）的人源化抗体，嵌合抗体或其片段，以形成其中因子X或因子IX与 复合物被抑制，并且给药足以预防或治疗哺乳动物的败血症。 本发明具有广泛的有用应用，包括治疗败血症，与败血症有关的疾病，以及诸如关节炎的炎性疾病。

    COMPOSITIONS AND METHODS FOR TREATING COAGULATION RELATED DISORDERS
    2.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING COAGULATION RELATED DISORDERS 审中-公开

    公开(公告)号：US20130011389A1

    公开(公告)日：2013-01-10

    申请号：US13327659

    申请日：2011-12-15

    申请人： Jin-An JIAO ,  Hing C. Wong ,  Jack O. Egan

    发明人： Jin-An JIAO ,  Hing C. Wong ,  Jack O. Egan

    IPC分类号： A61K39/395 ,  A61P11/00

    CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55

    摘要： Disclosed are methods for preventing or treating sepsis, a sepsis-related condition or an inflammatory disease in a mammal. In one embodiment, the method includes administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that binds specifically to tissue factor (TF) to form a complex in which factor X or factor IX binding to the complex is inhibited and the administration is sufficient to prevent or treat the sepsis in the mammal. The invention has a wide spectrum of useful applications including treating sepsis, disorders related to sepsis, and inflammatory diseases such as arthritis.

    COMPOSITIONS AND METHODS FOR TREATING COAGULATION RELATED DISORDERS
    3.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING COAGULATION RELATED DISORDERS 审中-公开
    用于治疗凝血相关疾病的组合物和方法

    公开(公告)号：US20090136501A1

    公开(公告)日：2009-05-28

    申请号：US12036188

    申请日：2008-02-22

    申请人： Jin-An JIAO ,  Hing C. Wong ,  Jack O. Egan

    发明人： Jin-An JIAO ,  Hing C. Wong ,  Jack O. Egan

    IPC分类号： A61K39/395

    CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55

    摘要： Disclosed are methods for preventing or treating sepsis, a sepsis-related condition or an inflammatory disease in a mammal. In one embodiment, the method includes administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that binds specifically to tissue factor (TF) to form a complex in which factor X or factor IX binding to the complex is inhibited and the administration is sufficient to prevent or treat the sepsis in the mammal. The invention has a wide spectrum of useful applications including treating sepsis, disorders related to sepsis, and inflammatory diseases such as arthritis.

    摘要翻译： 公开了用于预防或治疗哺乳动物中败血症，败血症相关病症或炎性疾病的方法。 在一个实施方案中，所述方法包括向哺乳动物施用治疗有效量的至少一种特异性结合组织因子（TF）的人源化抗体，嵌合抗体或其片段，以形成其中因子X或因子IX与 复合物被抑制，并且给药足以预防或治疗哺乳动物的败血症。 本发明具有广泛的有用应用，包括治疗败血症，与败血症有关的疾病，以及诸如关节炎的炎性疾病。

    Anti-tissue factor antibodies and methods of use thereof
    4.
    发明授权
    Anti-tissue factor antibodies and methods of use thereof 有权
    抗组织因子抗体及其使用方法

    公开(公告)号：US08007795B2

    公开(公告)日：2011-08-30

    申请号：US12404256

    申请日：2009-03-13

    申请人： Jin-an Jiao ,  Hing C. Wong ,  Esperanza Liliana Nieves ,  Luis A. Mosquera

    发明人： Jin-an Jiao ,  Hing C. Wong ,  Esperanza Liliana Nieves ,  Luis A. Mosquera

    IPC分类号： A61K39/395

    CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K16/467 ,  C07K2317/24 ,  C07K2319/00

    摘要： The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:FVIIa complex, effectively preventing factor X or FIX binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site. Also provided are humanized antibodies and fragments thereof that bind to the TF.

    摘要翻译： 本发明包括通过以高亲和力和特异性结合天然人TF而提供优异的抗凝血活性的抗体。 本发明的抗体可有效抑制体内血液凝固。 本发明的抗体可以单独或存在于TF：FVIIa复合物中的天然人TF结合，有效地防止因子X或FIX与TF或该复合物的结合，从而减少血液凝固。 本发明优选的抗体特异性结合主要为天然人TF的构象表位，该表位提供意想不到的强抗体结合位点。 还提供了结合TF的人源化抗体及其片段。

    Method for using antibodies for inhibiting blood coagulation
    8.
    发明授权
    Method for using antibodies for inhibiting blood coagulation 有权
    使用抗体抑制血液凝固的方法

    公开(公告)号：US07824677B2

    公开(公告)日：2010-11-02

    申请号：US12136718

    申请日：2008-06-10

    申请人： Hing C. Wong ,  Jin-An Jiao ,  Esperanza Liliana Nieves ,  Lawrence Luepschen

    发明人： Hing C. Wong ,  Jin-An Jiao ,  Esperanza Liliana Nieves ,  Lawrence Luepschen

    IPC分类号： A61K39/395

    CPC分类号： C07K16/36 ,  A61K38/00 ,  A61K39/395 ,  A61K2300/00

    摘要： The invention includes methods of inhibiting blood coagulation using antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Methods of the invention can effectively inhibit blood coagulation in vivo. Antibodies used in the methods of the invention can bind native human TF, either alone or present in a TF:VIIa complex, effectively preventing factor X binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies used in the methods of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site.

    摘要翻译： 本发明包括使用通过以高亲和性和特异性结合天然人TF提供优异抗凝血活性的抗体来抑制血液凝固的方法。 本发明的方法可有效抑制体内血液凝固。 用于本发明方法的抗体可以单独或存在于TF：VIIa复合物中的天然人TF结合，有效地防止因子X结合TF或该复合物，从而减少血液凝固。 用于本发明方法的优选抗体特异性结合构成天然人TF的构象表位，该表位提供了意想不到的强抗体结合位点。

    MHC molecules and uses thereof
    10.
    发明授权
    MHC molecules and uses thereof 失效
    MHC分子及其用途

    公开(公告)号：US06309645B1

    公开(公告)日：2001-10-30

    申请号：US09067615

    申请日：1998-04-28

    申请人： Peter R. Rhode ,  Jin-An Jiao ,  Martin Burkhardt ,  Hing C. Wong

    发明人： Peter R. Rhode ,  Jin-An Jiao ,  Martin Burkhardt ,  Hing C. Wong

    IPC分类号： A61K3900

    CPC分类号： C07K14/70539 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/6043 ,  A61K2039/622 ,  C07K2319/00 ,  C07K2319/02

    摘要： The present invention relates to novel complexes of major histocomability complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to loaded MHC complexes that include at least one MHC molecule with a peptide-binding groove and a presenting peptide non-covalently linked to the MHC protein. In another aspect, the invention features single chain MHC class II peptide fusion complexes with a presenting peptide covalently linked to the peptide binding grove of the complex. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.

    摘要翻译： 本发明涉及主要组织学复合物（MHC）分子的新型复合物和这种复合物的用途。 一方面，本发明涉及包含至少一个具有肽结合槽的MHC分子和与MHC蛋白非共价连接的呈递肽的负载的MHC复合物。 另一方面，本发明的特征在于具有与复合物的肽结合树共价连接的呈递肽的单链MHC II类肽融合复合物。 本发明的MHC复合物可用于多种应用，包括：1）用于鉴定和分离调节所选T细胞活性的肽的体外筛选，包括作为T细胞受体拮抗剂和部分激动剂的肽，以及2） 抑制或诱导哺乳动物的免疫应答。