公开(公告)号：US20120220647A1

公开(公告)日：2012-08-30

申请号：US13496108

申请日：2009-09-14

申请人： Jin-Ho Choy ,  Dae-Hwan Park ,  Jaeyong Cho

发明人： Jin-Ho Choy ,  Dae-Hwan Park ,  Jaeyong Cho

IPC分类号： A61K31/7088 ,  A61P35/00

CPC分类号： A61K9/0019

摘要： A nanohybrid of the potent gene therapeutic agent siRNA (small interfering RNA) and a target-specific layered inorganic hydroxide, a preparation method thereof, and a pharmaceutical composition for tumor treatment containing the target-specific, siRNA/layered inorganic hydroxide nanohybrid. The nanohybrid increases the in vivo stability of the siRNA, and a target-specific multifunctional ligand, which is bonded to the layered inorganic hydroxide and can bind specifically to a tumor, increases the efficiency of tumor-specific transfer of the siRNA such that the siRNA shows tumor therapeutic activity even at a relatively low dose. Thus, the nanohybrid will be widely useful for target-specific antitumor therapies.

摘要翻译： 强力基因治疗剂siRNA（小干扰RNA）和靶特异性层状无机氢氧化物的纳米杂交体及其制备方法和含有目标特异性siRNA /层状无机氢氧化物纳米混合物的肿瘤治疗用药物组合物。 纳米混合物增加了siRNA的体内稳定性，并且与层状无机氢氧化物结合并可以特异性结合到肿瘤的靶特异性多功能配体增加了siRNA的肿瘤特异性转移的效率，使得siRNA 即使在相对低的剂量下也显示肿瘤治疗活性。 因此，纳米混合物将广泛用于靶特异性抗肿瘤治疗。