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公开(公告)号：US08007795B2
公开(公告)日：2011-08-30
申请号：US12404256
申请日：2009-03-13
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , A61K2039/505 , C07K16/467 , C07K2317/24 , C07K2319/00
摘要： The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:FVIIa complex, effectively preventing factor X or FIX binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site. Also provided are humanized antibodies and fragments thereof that bind to the TF.
摘要翻译： 本发明包括通过以高亲和力和特异性结合天然人TF而提供优异的抗凝血活性的抗体。 本发明的抗体可有效抑制体内血液凝固。 本发明的抗体可以单独或存在于TF：FVIIa复合物中的天然人TF结合，有效地防止因子X或FIX与TF或该复合物的结合，从而减少血液凝固。 本发明优选的抗体特异性结合主要为天然人TF的构象表位，该表位提供意想不到的强抗体结合位点。 还提供了结合TF的人源化抗体及其片段。
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公开(公告)号：US07968094B2
公开(公告)日：2011-06-28
申请号：US12184205
申请日：2008-07-31
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , A61K2039/505 , C07K16/467 , C07K2317/24 , C07K2319/00
摘要： Disclosed is a method for preventing or treating thrombosis in a mammal such as a primate and particularly a human patient. A preferred method includes administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that binds specifically to human tissue factor (TF). Additional methods and kits are provided.
摘要翻译： 公开了一种预防或治疗哺乳动物如灵长类动物，特别是人类患者血栓形成的方法。 优选的方法包括向哺乳动物施用治疗有效量的与人组织因子（TF）特异性结合的至少一种人源化抗体，嵌合抗体或其片段。 提供其他方法和试剂盒。
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公开(公告)号：US20090252726A1
公开(公告)日：2009-10-08
申请号：US12404256
申请日：2009-03-13
IPC分类号： A61K39/395 , C07K16/18 , C12P21/02 , A61P7/02
CPC分类号： C07K16/36 , A61K2039/505 , C07K16/467 , C07K2317/24 , C07K2319/00
摘要： The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:FVIIa complex, effectively preventing factor X or FIX binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site. Also provided are humanized antibodies and fragments thereof that bind to the TF.
摘要翻译： 本发明包括通过以高亲和力和特异性结合天然人TF而提供优异的抗凝血活性的抗体。 本发明的抗体可有效抑制体内血液凝固。 本发明的抗体可以单独或存在于TF：FVIIa复合物中的天然人TF结合，有效地防止因子X或FIX与TF或该复合物的结合，从而减少血液凝固。 本发明优选的抗体特异性结合主要为天然人TF的构象表位，该表位提供意想不到的强抗体结合位点。 还提供了结合TF的人源化抗体及其片段。
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公开(公告)号：US5986065A
公开(公告)日：1999-11-16
申请号：US814806
申请日：1997-03-10
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P7/02 , A61P9/00 , C07K16/28 , C07K16/36 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/08 , C12Q1/68
CPC分类号： C07K16/36 , A61K39/395 , A61K38/00
摘要： The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:VIIa complex, effectively preventing factor X binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site.
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公开(公告)号：US07824677B2
公开(公告)日：2010-11-02
申请号：US12136718
申请日：2008-06-10
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , A61K38/00 , A61K39/395 , A61K2300/00
摘要： The invention includes methods of inhibiting blood coagulation using antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Methods of the invention can effectively inhibit blood coagulation in vivo. Antibodies used in the methods of the invention can bind native human TF, either alone or present in a TF:VIIa complex, effectively preventing factor X binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies used in the methods of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site.
摘要翻译： 本发明包括使用通过以高亲和性和特异性结合天然人TF提供优异抗凝血活性的抗体来抑制血液凝固的方法。 本发明的方法可有效抑制体内血液凝固。 用于本发明方法的抗体可以单独或存在于TF：VIIa复合物中的天然人TF结合，有效地防止因子X结合TF或该复合物，从而减少血液凝固。 用于本发明方法的优选抗体特异性结合构成天然人TF的构象表位，该表位提供了意想不到的强抗体结合位点。
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公开(公告)号：US20090041766A1
公开(公告)日：2009-02-12
申请号：US12136718
申请日：2008-06-10
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , A61K38/00 , A61K39/395 , A61K2300/00
摘要： The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:VIIa complex, effectively preventing factor X binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site.
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公开(公告)号：US06555319B2
公开(公告)日：2003-04-29
申请号：US09293854
申请日：1999-04-16
IPC分类号： G01N3353
CPC分类号： C07K16/36 , A61K38/00 , A61K39/395 , A61K2300/00
摘要： The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:VIIa complex, effectively preventing factor X binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site.
摘要翻译： 本发明包括通过以高亲和力和特异性结合天然人TF而提供优异抗凝血活性的抗体。 本发明的抗体可有效抑制体内血液凝固。 本发明的抗体可以单独或存在于TF：VIIa复合物中的天然人TF结合，有效地防止因子X结合TF或该复合物，从而减少血液凝固。 本发明优选的抗体特异性结合主要为天然人TF的构象表位，该表位提供意想不到的强抗体结合位点。
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