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1.
公开(公告)号:US08338565B2
公开(公告)日:2012-12-25
申请号:US12544604
申请日:2009-08-20
申请人: Jinbo Lee , Julian F. Bond , Nicholas Terrett , Frank G. Favaloro, Jr. , Daniel Wang , Timothy F. Briggs , Benjamin Adam Seigal , Wei-Chuan Sun , Stephen P. Hale
发明人: Jinbo Lee , Julian F. Bond , Nicholas Terrett , Frank G. Favaloro, Jr. , Daniel Wang , Timothy F. Briggs , Benjamin Adam Seigal , Wei-Chuan Sun , Stephen P. Hale
CPC分类号: C07D273/00 , C07D257/02
摘要: Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.
摘要翻译: 本文公开了大环化合物及其合成和使用的方法。 特别地,公开了调节肿瘤坏死因子α的活性和/或可用于治疗诸如类风湿性关节炎,牛皮癣和哮喘等医学病症的大环化合物。
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2.
公开(公告)号:US20100152099A1
公开(公告)日:2010-06-17
申请号:US12544604
申请日:2009-08-20
申请人: Jinbo Lee , Julian F. Bond , Nicholas Terrett , Frank G. Favaloro, JR. , Daniel Wang , Timothy F. Briggs , Benjamin A. Seigal , Wei-Chuan Sun , Stephen P. Hale
发明人: Jinbo Lee , Julian F. Bond , Nicholas Terrett , Frank G. Favaloro, JR. , Daniel Wang , Timothy F. Briggs , Benjamin A. Seigal , Wei-Chuan Sun , Stephen P. Hale
CPC分类号: C07D273/00 , C07D257/02
摘要: The invention provides macrocyclic compounds and methods for their synthesis and use. In particular, the invention provides macrocyclic compounds that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.
摘要翻译: 本发明提供了大环化合物及其合成和使用方法。 特别地,本发明提供调节肿瘤坏死因子α活性的大环化合物和/或可用于治疗诸如类风湿性关节炎,牛皮癣和哮喘的医学病症。
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