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    Recombitope peptides
    2.
    发明授权
    Recombitope peptides 失效
    重组单抗肽

    公开(公告)号：US07211408B2

    公开(公告)日：2007-05-01

    申请号：US10463113

    申请日：2003-06-16

    申请人： Bruce L. Rogers ,  Jay P. Morgenstern ,  Julian F. Bond ,  Richard D. Garman ,  Julia L. Greenstein ,  Mei-Chang Kuo ,  Malcolm Morville

    发明人： Bruce L. Rogers ,  Jay P. Morgenstern ,  Julian F. Bond ,  Richard D. Garman ,  Julia L. Greenstein ,  Mei-Chang Kuo ,  Malcolm Morville

    IPC分类号： G01N33/00 ,  C12N15/09 ,  C07K1/00

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/415 ,  C07K14/47 ,  C07K14/4705 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/40 ,  C12N15/62 ,  G01N33/5091 ,  Y10S530/806 ,  Y10S530/858 ,  Y10S530/868

    摘要： The present invention provides peptides having T cell stimulating activity termed recombitope peptides. Recombitope peptides of the invention preferably comprise at least two T cell epitopes derived from the same or from different protein antigens, and more preferably comprise at least two regions, each region preferably having human T cell stimulating activity and each region comprising at least one T cell epitope derived from a protein antigen. Recombitope peptides of the invention can be derived from protein allergens, autoantigens, or other protein antigens. The invention also provides methods of diagnosing sensitivity to a protein allergen or other protein antigen in an individual, methods to treat such sensitivity and therapeutic compositions comprising one or more recombitope peptides. The invention further provides methods for designing recombitope peptides of the invention where the protein antigen to which the individual is sensitive has unknown or ill-defined T cell epitopes.

    摘要翻译： 本发明提供了称为重组竞争肽的具有T细胞刺激活性的肽。 本发明的重组匹配肽优选包含至少两种衍生自相同或不同蛋白质抗原的T细胞表位，更优选包含至少两个区域，每个区域优选具有人T细胞刺激活性，每个区域包含至少一个T细胞 衍生自蛋白质抗原的表位。 本发明的重组蛋白多肽可以衍生自蛋白质过敏原，自身抗原或其他蛋白质抗原。 本发明还提供诊断个体中蛋白质变应原或其他蛋白质抗原的敏感性的方法，治疗这种敏感性的方法和包含一种或多种重组蛋白多肽的治疗组合物的方法。 本发明还提供了用于设计本发明的重组蛋白肽的方法，其中个体敏感的蛋白质抗原具有未知或不明确的T细胞表位。

    Allergenic proteins and peptides from Japanese cedar pollen
    4.
    发明授权
    Allergenic proteins and peptides from Japanese cedar pollen 有权
    来自日本雪松花粉的过敏蛋白和肽

    公开(公告)号：US08540999B2

    公开(公告)日：2013-09-24

    申请号：US10931260

    申请日：2004-08-30

    申请人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-Chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    发明人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-Chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    IPC分类号： A61K39/00 ,  A61K39/35 ,  A61K39/36 ,  A61K39/38 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00

    CPC分类号： C07K14/415 ,  A61K38/00 ,  A61K39/00 ,  C07K16/16

    摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.

    摘要翻译： 本发明提供了编码粳稻主要花粉过敏原Cryj I，Cryj II，Jun s I和Jun v I的核酸序列及其片段或肽。 本发明还提供纯化的Cry j I，Cryj II，Jun s I和Jun v I，以及在用编码Cryj I，Cryj II，Jun的核酸序列转化的宿主细胞中产生的至少一个片段 I和Jun v I或其至少一个片段，以及Cry j I，Cry j II，Jun s I或Jun v I或其至少一个片段的片段，以及Cryj I，Cryj II，Jun 我或Jun v我合成了。 Cry j I，Cry j II，Jun s I和Jun v I及其片段可用于诊断，治疗和预防日本雪松花粉病。 本发明还提供了Cryj I和Cryj II的分离的肽。 本发明范围内的肽包含至少一个T细胞表位，或优选至少两个Cryj I或Cryj II的T细胞表位。 本发明还涉及与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的改性肽。 还提供了治疗或诊断个体对日本雪松花粉和治疗组合物的方法，以及包含一种或多种本发明的肽的多肽制剂。

    Allergenic proteins and peptides from Japanese cedar pollen
    5.
    发明授权
    Allergenic proteins and peptides from Japanese cedar pollen 失效

    公开(公告)号：US06982326B1

    公开(公告)日：2006-01-03

    申请号：US09240203

    申请日：1999-01-29

    申请人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    发明人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    IPC分类号： C07H21/04

    CPC分类号： C07K14/415 ,  A61K38/00 ,  A61K39/00 ,  C07K16/16

    摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.

    T cell peptides of the CRX JII allergen
    7.
    发明授权
    T cell peptides of the CRX JII allergen 失效
    CRX JII变应原的T细胞肽

    公开(公告)号：US6090386A

    公开(公告)日：2000-07-18

    申请号：US467023

    申请日：1995-06-06

    申请人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    发明人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    IPC分类号： A61K39/00 ,  C07K14/415 ,  C07K14/725 ,  A61K38/10 ,  A61K39/36 ,  C07K7/08

    CPC分类号： C07K14/415 ,  A61K39/00

    摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.

    摘要翻译： 本发明提供了编码粳稻主要花粉过敏原Cryj I，Cryj II，Jun s I和Jun v I的核酸序列及其片段或肽。 本发明还提供纯化的Cry j I，Cryj II，Jun s I和Jun v I，以及在用编码Cryj I，Cryj II，Jun的核酸序列转化的宿主细胞中产生的至少一个片段 I和Jun v I或其至少一个片段，以及Cry j I，Cry j II，Jun s I或Jun v I或其至少一个片段的片段，以及Cryj I，Cryj II，Jun 我或Jun v我合成了。 Cry j I，Cry j II，Jun s I和Jun v I及其片段可用于诊断，治疗和预防日本雪松花粉病。 本发明还提供了Cryj I和Cryj II的分离的肽。 本发明范围内的肽包含至少一个T细胞表位，或优选至少两个Cryj I或Cryj II的T细胞表位。 本发明还涉及与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的改性肽。 还提供了治疗或诊断个体对日本雪松花粉和治疗组合物的方法，以及包含一种或多种本发明的肽的多肽制剂。