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1.发明申请公开(公告)号：US20080081815A1
公开(公告)日：2008-04-03
申请号：US11541269
申请日：2006-09-29
申请人： Jinhwa Lee , Jeong Min Kim , Chong-Hwan Jonathan Chang , Suk Youn Kang , Hee Jeong Seo , Kwang-Seop Song , Sung-Han Lee , Kwang-Woo Ahn
发明人： Jinhwa Lee , Jeong Min Kim , Chong-Hwan Jonathan Chang , Suk Youn Kang , Hee Jeong Seo , Kwang-Seop Song , Sung-Han Lee , Kwang-Woo Ahn
IPC分类号： A61K31/501 , A61K31/497 , A61K31/433 , A61K31/4245 , A61K31/4196 , C07D413/14 , C07D417/14 , C07D403/14
CPC分类号： C07D413/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要： A novel heteroaryl-pyrazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB1 receptor inverse agonist or antagonist, which is useful for preventing or treating obesity and obesity-related metabolic disorders. The prevention also provide a method for preparing same, a pharmaceutical composition containing same, and a method for preventing or treating obesity and obesity-related metabolic disorders.
摘要翻译： 式（I）的新型杂芳基 - 吡唑化合物或其药学上可接受的盐作为大麻素CB 1受体反向激动剂或拮抗剂是有效的，其可用于预防或治疗肥胖症和肥胖相关代谢 疾病 预防还提供其制备方法，含有该组合物的药物组合物，以及预防或治疗肥胖症和与肥胖有关的代谢紊乱的方法。
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2.发明授权公开(公告)号：US07875647B2
公开(公告)日：2011-01-25
申请号：US11863501
申请日：2007-09-28
申请人： Jinhwa Lee , Jeong Min Kim , Chong-Hwan Jonathan Chang , Suk Ho Lee , Hee Jeong Seo , Suk Youn Kang , Kwang-Seop Song , Jong Yup Kim , Min-ah Kim , Sung-han Lee , Kwang-Woo Ahn , Myung Eun Jung , Ji-Hyun Park
发明人： Jinhwa Lee , Jeong Min Kim , Chong-Hwan Jonathan Chang , Suk Ho Lee , Hee Jeong Seo , Suk Youn Kang , Kwang-Seop Song , Jong Yup Kim , Min-ah Kim , Sung-han Lee , Kwang-Woo Ahn , Myung Eun Jung , Ji-Hyun Park
IPC分类号： A61K31/415 , A61K31/4196 , C07D231/10 , C07D285/12 , C07D417/14
CPC分类号： C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： A heteroaryl-pyrazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB1 receptor inverse agonist or antagonist, which is useful for preventing or treating obesity and obesity-related metabolic disorders. The present invention also provides a method for preparing the inventive heteroaryl-pyrasole compounds or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and a method for preventing or treating obesity and obesity-related metabolic disorders.
摘要翻译： 式（I）的杂芳基 - 吡唑化合物或其药学上可接受的盐作为大麻素CB1受体反向激动剂或拮抗剂是有效的，其可用于预防或治疗肥胖症和与肥胖有关的代谢紊乱。 本发明还提供了制备本发明的杂芳基 - 吡咯烷酮化合物或其药学上可接受的盐，含有它们的药物组合物的方法，以及用于预防或治疗肥胖症和与肥胖相关的代谢紊乱的方法。
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公开(公告)号：US20110015377A1
公开(公告)日：2011-01-20
申请号：US12812176
申请日：2009-01-09
申请人： Hee-Bok Oh , Bong-Su Kim , Gi-Eun Rhie , Jeong-Hoon Chun , Hun Kim , Sinkoo Yeo , Mahnhoon Park , Chong-Hwan Jonathan Chang , Mi Sun Ahn
发明人： Hee-Bok Oh , Bong-Su Kim , Gi-Eun Rhie , Jeong-Hoon Chun , Hun Kim , Sinkoo Yeo , Mahnhoon Park , Chong-Hwan Jonathan Chang , Mi Sun Ahn
IPC分类号： C07K1/36
摘要： The method of the present invention comprising successive column chromatography processes for the purification of an anthrax protective antigen can achieve an improved purity of the anthrax protective antigen product by effectively removing impurities (e.g., cellular residual proteins in the culture solution) without the loss of anthrax protective antigen. Therefore, the method of the present invention can be advantageously used for economically producing the anthrax protective antigen on a large scale.
摘要翻译： 包含用于纯化炭疽保护性抗原的连续柱层析方法的本发明的方法可以通过有效地除去杂质（例如培养液中的细胞残留蛋白质）而不损失炭疽来实现改善的炭疽保护性抗原产物的纯度 保护性抗原。 因此，本发明的方法可有利地用于大规模经济地生产炭疽保护抗原。
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公开(公告)号：US08519108B2
公开(公告)日：2013-08-27
申请号：US12812176
申请日：2009-01-09
申请人： Hee-Bok Oh , Bong-Su Kim , Gi-Eun Rhie , Jeong-Hoon Chun , Hun Kim , SinKoo Yeo , MahnHoon Park , Chong-Hwan Jonathan Chang , Mi Sun Ahn
发明人： Hee-Bok Oh , Bong-Su Kim , Gi-Eun Rhie , Jeong-Hoon Chun , Hun Kim , SinKoo Yeo , MahnHoon Park , Chong-Hwan Jonathan Chang , Mi Sun Ahn
IPC分类号： C07K14/32
摘要： The method of the present invention comprising successive column chromatography processes for the purification of an anthrax protective antigen can achieve an improved purity of the anthrax protective antigen product by effectively removing impurities (e.g., cellular residual proteins in the culture solution) without the loss of anthrax protective antigen. Therefore, the method of the present invention can be advantageously used for economically producing the anthrax protective antigen on a large scale.
摘要翻译： 包含用于纯化炭疽保护性抗原的连续柱层析方法的本发明的方法可以通过有效地除去杂质（例如培养液中的细胞残留蛋白质）而不损失炭疽来实现改善的炭疽保护性抗原产物的纯度 保护性抗原。 因此，本发明的方法可有利地用于大规模经济地生产炭疽保护抗原。
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