公开(公告)号：US20110092797A1

公开(公告)日：2011-04-21

申请号：US12922257

申请日：2009-02-20

申请人： Jinnan Wang ,  Vasily Yarnykh ,  Chun Yuan

发明人： Jinnan Wang ,  Vasily Yarnykh ,  Chun Yuan

IPC分类号： A61B5/055

CPC分类号： G01R33/56 ,  A61B5/05 ,  G01R33/5607 ,  G01R33/5617 ,  G01R33/563

摘要： An improved motion-sensitization driven equilibrium (iMSDE) sequence based upon an MLEV-4 sequence is used for black-blood vessel wall imaging. The MSDE pulse pattern that is used us a preparation sequence for other procedures employed to acquire images has been modified to produce the iMSDE sequence by the addition of a second 180 degree refocusing pulse and two motion sensitization gradients. The iMSDE sequence thus includes a group of four radio frequency (RF) pulses, as well as additional magnetic gradient pulses that are not included in the conventional MSDE sequence. Computer simulations indicate that this new pulse sequence is substantially more immune to local B1 inhomogeneity than conventional sequences. In vivo experiments have demonstrated significant signal improvement at high first-order moments (m1) conditions compared to the traditional MSDE sequence.

摘要翻译： 基于MLEV-4序列的改进的运动敏化驱动平衡（iMSDE）序列用于黑血管壁成像。 使用我们用于采集图像的其他过程的准备顺序的MSDE脉冲图案已被修改，以通过添加第二180度重聚焦脉冲和两个运动敏化梯度来产生iMSDE序列。 因此，iMSDE序列包括一组四个射频（RF）脉冲以及不包括在常规MSDE序列中的附加磁梯度脉冲。 计算机模拟表明，这种新的脉冲序列比常规序列显着地更多地免疫局部B1不均匀性。 与传统的MSDE序列相比，体内实验已经证明在高一阶矩（m1）条件下显着的信号改善。

公开(公告)号：US09448296B2

公开(公告)日：2016-09-20

申请号：US12922257

申请日：2009-02-20

申请人： Jinnan Wang ,  Vasily Yarnykh ,  Chun Yuan

发明人： Jinnan Wang ,  Vasily Yarnykh ,  Chun Yuan

IPC分类号： A61B5/05 ,  G01R33/56 ,  G01R33/561 ,  G01R33/563

CPC分类号： G01R33/56 ,  A61B5/05 ,  G01R33/5607 ,  G01R33/5617 ,  G01R33/563

摘要： An improved motion-sensitization driven equilibrium (iMSDE) sequence based upon an MLEV-4 sequence is used for black-blood vessel wall imaging. The MSDE pulse pattern that is used us a preparation sequence for other procedures employed to acquire images has been modified to produce the iMSDE sequence by the addition of a second 180 degree refocusing pulse and two motion sensitization gradients. The iMSDE sequence thus includes a group of four radio frequency (RF) pulses, as well as additional magnetic gradient pulses that are not included in the conventional MSDE sequence. Computer simulations indicate that this new pulse sequence is substantially more immune to local B1 inhomogeneity than conventional sequences. In vivo experiments have demonstrated significant signal improvement at high first-order moments (m1) conditions compared to the traditional MSDE sequence.

摘要翻译： 基于MLEV-4序列的改进的运动敏化驱动平衡（iMSDE）序列用于黑血管壁成像。 使用我们用于采集图像的其他过程的准备顺序的MSDE脉冲图案已被修改，以通过添加第二180度重聚焦脉冲和两个运动敏化梯度来产生iMSDE序列。 因此，iMSDE序列包括一组四个射频（RF）脉冲以及不包括在常规MSDE序列中的附加磁梯度脉冲。 计算机模拟表明，这种新的脉冲序列比常规序列显着地更多地免疫局部B1不均匀性。 与传统的MSDE序列相比，体内实验已经证明在高一阶矩（m1）条件下显着的信号改善。

公开(公告)号：US20060184002A1

公开(公告)日：2006-08-17

申请号：US11385201

申请日：2006-03-21

申请人： Vasily Yarnykh ,  Chun Yuan

发明人： Vasily Yarnykh ,  Chun Yuan

IPC分类号： A61B5/05

CPC分类号： G01R33/5607 ,  G01R33/5601

摘要： A reduced field-of-view (FOV) imaging technique combines suppression of signals from outer volume and inflowing blood. Both outer volume and blood suppression are achieved using an SFQIR (Small-FOV Quadruple-inversion-Recovery) preparative pulse sequence including two double-inversion pulse pairs separated by appropriate delays. Within each pair, inversion pulses are successively applied to the imaged slice and the slab orthogonal to the imaging plane, with the thickness equal to the FOV size in the phase-encoding direction. Each double-inversion results in a reinversion of the magnetization in a central part of the FOV, while outer areas of the FOV and inflowing blood remain inverted. The SFQIR module was implemented for single-slice and multislice acquisition with a fast spin-echo readout sequence. Timing parameters of the sequence corresponding to the maximal suppression efficiency can be found by niiziig variation of the normalized signal over the entire range of T1 occurring in tissues.

摘要翻译： 减少的视野（FOV）成像技术结合了来自外部体积和流入血液的信号的抑制。 外部体积和血液抑制都使用包含两个双反转脉冲对的SFQIR（小FOV四重反转 - 恢复）制备脉冲序列来实现，该两个双反转脉冲对由适当的延迟分开。 在每对中，反转脉冲被连续施加到成像的切片和与成像平面垂直的平板，其厚度等于相位编码方向上的FOV大小。 每次双反转导致FOV中心部分的磁化反转，FOV和流入血液的外部区域保持反转。 SFQIR模块实现了具有快速自旋回波读出序列的单片和多分辨率采集。 对应于最大抑制效率的序列的定时参数可以通过归一化信号在组织中发生的整个T 1范围内的微分变化来发现。

公开(公告)号：US20100142784A1

公开(公告)日：2010-06-10

申请号：US12594784

申请日：2008-05-15

申请人： Vasily Yarnykh

发明人： Vasily Yarnykh

IPC分类号： G06K9/54 ,  G06T7/00

CPC分类号： G01R33/563 ,  G01R33/4608 ,  G01R33/48 ,  G01R33/5605 ,  G01R33/56366

摘要： A two-point reconstruction technique provides an efficient clinical method for measuring parametric bound pool fraction and cross-relaxation rate constant spatial distributions in biological objects from two experimental measurements based on magnetization transfer effect obtained in magnetic resonance imaging (MRI). The method is based on linearization of an analytical pulsed magnetization transfer mathematical model so that spatial distribution maps of the bound pool fraction and cross-relaxation rate constant can be obtained in a time-efficient manner by using only two experimental magnetization transfer images of the bio-logical object in which water and macromolecules are present.

摘要翻译： 基于在磁共振成像（MRI）中获得的磁化转移效应，两次实验测量，两点重建技术提供了用于测量生物对象中参数结合池分数和交叉弛豫率恒定空间分布的有效临床方法。 该方法基于分析脉冲磁化传递数学模型的线性化，使得可以以有效的方式通过仅使用生物的两个实验磁化转移图像来获得结合池部分和交叉弛豫速率常数的空间分布图 存在水和大分子的物质。

公开(公告)号：US08369599B2

公开(公告)日：2013-02-05

申请号：US12594784

申请日：2008-05-15

申请人： Vasily Yarnykh

发明人： Vasily Yarnykh

IPC分类号： A61B6/03

CPC分类号： G01R33/563 ,  G01R33/4608 ,  G01R33/48 ,  G01R33/5605 ,  G01R33/56366

摘要： A two-point reconstruction technique provides an efficient clinical method for measuring parametric bound pool fraction and cross-relaxation rate constant spatial distributions in biological objects from two experimental measurements based on magnetization transfer effect obtained in magnetic resonance imaging (MRI). The method is based on linearization of an analytical pulsed magnetization transfer mathematical model so that spatial distribution maps of the bound pool fraction and cross-relaxation rate constant can be obtained in a time-efficient manner by using only two experimental magnetization transfer images of the bio-logical object in which water and macromolecules are present.

摘要翻译： 基于在磁共振成像（MRI）中获得的磁化转移效应，两次实验测量，两点重建技术提供了用于测量生物对象中参数结合池分数和交叉弛豫率恒定空间分布的有效临床方法。 该方法基于分析脉冲磁化传递数学模型的线性化，使得可以以有效的方式通过仅使用生物的两个实验磁化转移图像来获得结合池部分和交叉弛豫速率常数的空间分布图 存在水和大分子的物质。