公开(公告)号：US20140221507A1

公开(公告)日：2014-08-07

申请号：US14131212

申请日：2012-07-02

申请人： Jochen Schwenk ,  Peter Nilsson ,  Mathias Uhlén

发明人： Jochen Schwenk ,  Peter Nilsson ,  Mathias Uhlén

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/493 ,  G01N2800/347

摘要： There is provided a method of determining whether a subject belongs to a first or a second group of subjects, wherein the risk of having or developing of a renal impairment is higher in the first group than in the second group, comprising the steps of: a) measuring an amount of fibulin 1 in a sample from the subject to obtain a sample value; b) comparing the sample value to a reference value; and if the sample value is higher than the reference value, c1) concluding that the subject belongs to the first group; and if the sample value is lower than the reference value, c2) concluding that the subject belongs to the second group, wherein the sample is an optionally modified sample derived from urine or blood, such as an optionally diluted serum or plasma sample. Associated means are also provided.

摘要翻译： 提供了确定受试者是否属于第一组或第二组受试者的方法，其中在第一组中具有或发展肾损伤的风险高于第二组，其包括以下步骤：a ）测量来自受试者的样品中的纤维蛋白1的量以获得样品值; b）将样本值与参考值进行比较; 并且如果样本值高于参考值，则c1）认定该受试者属于第一组; 并且如果样品值低于参考值，则c2）断定受试者属于第二组，其中样品是衍生自尿液或血液的任选修饰的样品，例如任选稀释的血清或血浆样品。 还提供了相关的手段。

公开(公告)号：US20120178108A1

公开(公告)日：2012-07-12

申请号：US13379798

申请日：2009-06-26

申请人： Mathias Uhlén ,  Jochen Schwenk

发明人： Mathias Uhlén ,  Jochen Schwenk

IPC分类号： G01N21/64 ,  G01N33/82 ,  G01N33/53

CPC分类号： G01N33/5306 ,  G01N33/5375

摘要： In the present disclosure, there is provided a method for improving the immunodetectability of at least one protein in an optionally diluted sample of blood, serum or plasma, comprising a step of heating the sample to a temperature of 64-85° C. prior to a contact between the sample and at least one affinity ligand for detection and/or quantification of the at least one protein.

摘要翻译： 在本公开内容中，提供了一种用于提高任选稀释的血液，血清或血浆样品中至少一种蛋白质的免疫检测性的方法，包括将样品加热至温度为64-85℃， 所述样品和至少一种亲和配体之间的接触用于所述至少一种蛋白质的检测和/或定量。