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    Method for immunizing animal, composition for immunization, method for producing antibody, method for producing hybridoma, and method for producing monoclonal antibody
    1.
    发明授权
    Method for immunizing animal, composition for immunization, method for producing antibody, method for producing hybridoma, and method for producing monoclonal antibody 有权
    免疫动物的方法，免疫组合物，抗体的制造方法，杂交瘤的制造方法以及单克隆抗体的制造方法

    公开(公告)号：US08901099B2

    公开(公告)日：2014-12-02

    申请号：US13681700

    申请日：2012-11-20

    申请人： Joe Chiba ,  Sekisui Chemical Co., Ltd.

    发明人： Joe Chiba ,  Jun-ichi Hata ,  Naoki Nishiguchi ,  Masahiro Furutani

    IPC分类号： A61K48/00 ,  C12N5/04 ,  C12N15/06 ,  A61K39/00 ,  A61K39/385 ,  C07K16/28

    CPC分类号： A61K39/00 ,  A61K39/0005 ,  A61K39/385 ,  A61K2039/53 ,  A61K2039/6068 ,  C07K16/2869 ,  C07K2319/35

    摘要： It is an object of the present invention to a method whereby a humoral immune response is induced more efficiently in producing an antibody against an antigen protein by gene immunization. A fusion gene composed of a gene encoding the full-length of a part of the antigen protein or a gene encoding a chaperonin subunit or a chaperonin subunit linkage linked thereto is administered to express the fusion gene in the animal, thereby inducing a humoral immune response to an antigen protein by administering. An example of the chaperonin includes Escherichia coli GroEL. There is also provided with a composition for immunization, a method for producing an antibody, a method for producing a hybridoma, and a method for producing a monoclonal antibody.

    摘要翻译： 本发明的目的是提供一种通过基因免疫在产生针对抗原蛋白的抗体中更有效地诱导体液免疫应答的方法。 施用由编码全长一部分抗原蛋白的基因或编码伴侣伴侣亚基的基因或与其相连的伴侣伴侣亚基的基因组成的融合基因，以表达动物中的融合基因，由此诱导体液免疫应答 通过给予抗原蛋白。 伴侣蛋白的一个实例包括大肠杆菌GroEL。 还提供了用于免疫的组合物，抗体的制备方法，杂交瘤的制备方法和单克隆抗体的制备方法。

    Anti-human CCR7 antibody, hybridoma, nucleic acid, vector, cell, pharmaceutical composition, and antibody-immobilized carrier
    2.
    发明授权
    Anti-human CCR7 antibody, hybridoma, nucleic acid, vector, cell, pharmaceutical composition, and antibody-immobilized carrier 有权
    抗人CCR7抗体，杂交瘤，核酸，载体，细胞，药物组合物和抗体固定载体

    公开(公告)号：US09505844B2

    公开(公告)日：2016-11-29

    申请号：US14489898

    申请日：2014-09-18

    申请人： Sekisui Chemical Co., Ltd. ,  NB HEALTH LABORATORY CO., LTD.

    发明人： Naoki Nishiguchi ,  Akiyoshi Hirayama ,  Masahiro Furutani ,  Tatsuo Shimizu ,  Kiyoshi Takayama ,  Tomoko Shimizu ,  Kazuya Suzuki

    IPC分类号： C07K16/28 ,  A61K31/713 ,  A61K39/00

    CPC分类号： C07K16/2866 ,  A61K31/713 ,  A61K2039/505 ,  C07K2317/70 ,  C07K2317/76

    摘要： An anti-human-CC-motif-receptor-7 (anti-human-CCR7) antibody which is useful as a therapeutic agent for tissue fibrosis or cancer, and a pharmaceutical composition containing the anti-human CCR7 antibody, and the like is described. An anti-human CCR7 antibody specifically binding to an extracellular domain of human CCR7, having a heavy chain CDR3 containing an amino acid sequence represented by SEQ ID NO: 7, SEQ ID NO: 17, SEQ ID NO: 27, SEQ ID NO: 37, SEQ ID NO: 47, SEQ ID NO: 57, SEQ ID NO: 67, or SEQ ID NO: 77 is provided. Also provided is an anti-human CCR7 antibody having heavy chain CDRs 1-3 and light chain CDRs 1-3 containing amino acid sequences represented by SEQ ID NOs: 5-10, 15-20, 25-30, 35-40, 45-50, 55-60, 65-70, or 75-80. The anti-human CCR7 antibody of the present invention may be used as an active ingredient of a therapeutic agent for tissue fibrosis or cancer.

    摘要翻译： 描述可用作组织纤维化或癌症治疗剂的抗人CC-motif-receptor-7（抗人CCR7）抗体和含有抗人CCR7抗体的药物组合物等 。 特异性结合人CCR7细胞外结构域的抗人CCR7抗体，其具有含有SEQ ID NO：7，SEQ ID NO：17，SEQ ID NO：27，SEQ ID NO：17，SEQ ID NO：27，SEQ ID NO：17所示氨基酸序列的重链CDR3。 提供了37，SEQ ID NO：47，SEQ ID NO：57，SEQ ID NO：67或SEQ ID NO：77。 还提供了具有重链CDR 1-3的抗人CCR7抗体和含有由SEQ ID NO：5-10，15-20,25-30,35-40,45表示的氨基酸序列的轻链CDR 1-3 -50,55-60,65-70或75-80。 本发明的抗人CCR7抗体可以用作组织纤维化或癌症治疗剂的活性成分。