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1.发明授权公开(公告)号：US07718652B2
公开(公告)日：2010-05-18
申请号：US11955004
申请日：2007-12-12
IPC分类号： C07D285/16 , A61K31/5415
CPC分类号： C07D285/16
摘要： The present invention is directed to substituted benzothiadiazinedioxide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.
摘要翻译： 本发明涉及式I的取代苯并噻二嗪二
醇衍生物：或其药学上可接受的盐，立体异构体或互变异构体，其是单胺再摄取抑制剂，含有这些衍生物的组合物，及其用于预防和治疗病症的方法， 尤其是血管舒缩症状，性功能障碍，胃肠道疾病和泌尿生殖器疾病，抑郁症，内源性行为障碍，认知障碍，糖尿病性神经病，疼痛和其它疾病或病症。-
2.发明申请公开(公告)号：US20080161295A1
公开(公告)日：2008-07-03
申请号：US11955004
申请日：2007-12-12
IPC分类号： A61K31/5415 , C07D285/16 , A61P43/00
CPC分类号： C07D285/16
摘要： The present invention is directed to substituted benzothiadiazinedioxide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.
摘要翻译： 本发明涉及式I的取代苯并噻二嗪二
醇衍生物：或其药学上可接受的盐，立体异构体或互变异构体，其是单胺再摄取抑制剂，含有这些衍生物的组合物，及其用于预防和治疗病症的方法， 尤其是血管舒缩症状，性功能障碍，胃肠道疾病和泌尿生殖器疾病，抑郁症，内源性行为障碍，认知障碍，糖尿病性神经病，疼痛和其它疾病或病症。-
公开(公告)号：US20100029641A1
公开(公告)日：2010-02-04
申请号：US12548844
申请日：2009-08-27
申请人： Casey Cameron McComas , Stephen Todd Cohn , Andrew Fensome , Joel Adam Goldberg , Charles William Mann , Michael Anthony Marella , David John O'Neill , Joseph Peter Sabatucci , Eugene Anthony Terefenko , Eugene John Trybulski , An Thien Vu , Richard Page Woodworth, JR. , Puwen Zhang
发明人： Casey Cameron McComas , Stephen Todd Cohn , Andrew Fensome , Joel Adam Goldberg , Charles William Mann , Michael Anthony Marella , David John O'Neill , Joseph Peter Sabatucci , Eugene Anthony Terefenko , Eugene John Trybulski , An Thien Vu , Richard Page Woodworth, JR. , Puwen Zhang
IPC分类号： A61K31/5377 , C07D285/14 , C07D417/06 , A61K31/41 , A61K31/454 , A61P15/00 , A61P1/00 , A61P25/00 , A61P7/12
CPC分类号： C07D417/04 , C07D285/14 , C07D417/06
摘要： The present invention is directed to aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.
摘要翻译： 本发明涉及式I的芳基磺酰胺衍生物：或其药学上可接受的盐，立体异构体或互变异构体，其是单胺再摄取抑制剂，含有这些衍生物的组合物，及其用于预防和治疗病症的方法， 尤其是血管舒缩症状，性功能障碍，胃肠道疾病和泌尿生殖器疾病，抑郁症，内源性行为障碍，认知障碍，糖尿病性神经病，疼痛和其它疾病或病症。
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公开(公告)号：US07601722B2
公开(公告)日：2009-10-13
申请号：US11955018
申请日：2007-12-12
申请人： Casey Cameron McComas , Stephen Todd Cohn , Andrew Fensome , Joel Adam Goldberg , Charles William Mann , Michael Anthony Marella , David John O'Neill , Joseph Peter Sabatucci , Eugene Anthony Terefenko , Eugene John Trybulski , An Thien Vu , Richard Page Woodworth, Jr. , Puwen Zhang
发明人： Casey Cameron McComas , Stephen Todd Cohn , Andrew Fensome , Joel Adam Goldberg , Charles William Mann , Michael Anthony Marella , David John O'Neill , Joseph Peter Sabatucci , Eugene Anthony Terefenko , Eugene John Trybulski , An Thien Vu , Richard Page Woodworth, Jr. , Puwen Zhang
IPC分类号： A61K31/496 , A61K31/5377 , C07D413/06 , C07D403/06
CPC分类号： C07D417/04 , C07D285/14 , C07D417/06
摘要： The present invention is directed to aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.
摘要翻译： 本发明涉及式I的芳基磺酰胺衍生物：或其药学上可接受的盐，立体异构体或互变异构体，其是单胺再摄取抑制剂，含有这些衍生物的组合物，及其用于预防和治疗病症的方法， 尤其是血管舒缩症状，性功能障碍，胃肠道疾病和泌尿生殖器疾病，抑郁症，内源性行为障碍，认知障碍，糖尿病性神经病，疼痛和其它疾病或病症。
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5.发明申请公开(公告)号：US20080194654A1
公开(公告)日：2008-08-14
申请号：US11955204
申请日：2007-12-12
申请人： Casey Cameron McComas , Andrew Fensome , Joel Adam Goldberg , Charles William Mann , David John O'Neill , Joseph Peter Sabatucci , Eugene Anthony Terefenko , Eugene John Trybulski , An Thien Vu , Puwen Zhang
发明人： Casey Cameron McComas , Andrew Fensome , Joel Adam Goldberg , Charles William Mann , David John O'Neill , Joseph Peter Sabatucci , Eugene Anthony Terefenko , Eugene John Trybulski , An Thien Vu , Puwen Zhang
IPC分类号： A61K31/433 , C07D285/14 , A61P15/00 , A61P1/00 , A61P21/00 , A61P25/24 , A61P7/12 , A61P29/00
CPC分类号： C07D417/04 , C07D285/14 , C07D417/06
摘要： The present invention is directed to hydroxy-substituted aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.
摘要翻译： 本发明涉及式I的羟基取代的芳基磺酰胺衍生物：或其药学上可接受的盐，立体异构体或互变异构体，它们是单胺再摄取抑制剂，含有这些衍生物的组合物及其用于预防和治疗病症的方法 ，包括血管舒缩症状，性功能障碍，胃肠道疾病和泌尿生殖器疾病，抑郁症，内源性行为障碍，认知障碍，糖尿病性神经病，疼痛和其他疾病或病症。
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6.发明申请AMINOALKYL SUBSTITUTED ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE 审中-公开氨基取代的芳基磺酰胺衍生物及其使用方法公开(公告)号：US20080161366A1
公开(公告)日：2008-07-03
申请号：US11955195
申请日：2007-12-12
申请人： Casey Cameron McComas , Stephen Todd Cohn , Matthew Lantz Crawley , Andrew Fensome , Joel Adam Goldberg , Douglas John Jenkins , Callain Younghee Kim , Paige Erin Mahaney , Charles William Mann , Michael Anthony Marella , David John O'Neill , Joseph Peter Sabatucci , Eugene Anthony Terefenko , Eugene John Trybulski , An Thien Vu , Richard Page Woodworth , Puwen Zhang
发明人： Casey Cameron McComas , Stephen Todd Cohn , Matthew Lantz Crawley , Andrew Fensome , Joel Adam Goldberg , Douglas John Jenkins , Callain Younghee Kim , Paige Erin Mahaney , Charles William Mann , Michael Anthony Marella , David John O'Neill , Joseph Peter Sabatucci , Eugene Anthony Terefenko , Eugene John Trybulski , An Thien Vu , Richard Page Woodworth , Puwen Zhang
IPC分类号： A61K31/433 , C07D285/14 , A61P15/00 , A61P25/00 , A61P1/00 , A61P3/00
CPC分类号： C07D417/04 , C07D285/14 , C07D417/06
摘要： The present invention is directed to aminoalkyl-substituted aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.
摘要翻译： 本发明涉及式I的氨基烷基取代的芳基磺酰胺衍生物：或其药学上可接受的盐，立体异构体或互变异构体，它们是单胺再摄取抑制剂，含有这些衍生物的组合物及其用于预防和治疗病症的方法 ，包括血管舒缩症状，性功能障碍，胃肠道疾病和泌尿生殖器疾病，抑郁症，内源性行为障碍，认知障碍，糖尿病性神经病，疼痛和其他疾病或病症。
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公开(公告)号：US20080171737A1
公开(公告)日：2008-07-17
申请号：US11954466
申请日：2007-12-12
申请人： Andrew Fensome , Joel Adam Goldberg , Casey Cameron McComas , Charles William Mann , Edward George Melenski , Joseph Peter Sabatucci , Richard Page Woodworth
发明人： Andrew Fensome , Joel Adam Goldberg , Casey Cameron McComas , Charles William Mann , Edward George Melenski , Joseph Peter Sabatucci , Richard Page Woodworth
IPC分类号： A61K31/551 , C07D279/02 , A61K31/5415 , C07D291/08 , A61P1/00 , A61P25/00 , A61P13/00 , A61P15/00 , C07D285/15 , C07D243/08
CPC分类号： C07D279/02 , C07D285/15 , C07D291/08 , C07D417/04 , C07D419/04 , C07D419/06 , C07D487/08
摘要： The present invention is directed to cyclic sulfonamide derivatives of formula I: or a pharmaceutically acceptable salt thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behaviorial disorder, cognitive disorder, diabetic neuropathy, pain, and other diseases or disorders.
摘要翻译： 本发明涉及式I的环状磺酰胺衍生物或其药学上可接受的盐，它们是单胺再摄取抑制剂，含有这些衍生物的组合物，及其用于预防和治疗病症的方法，包括尤其是血管舒缩 症状，性功能障碍，胃肠道疾病和泌尿生殖器疾病，抑郁症，内源性行为障碍，认知障碍，糖尿病性神经病，疼痛和其他疾病或障碍。
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