公开(公告)号：US20100029641A1

公开(公告)日：2010-02-04

申请号：US12548844

申请日：2009-08-27

申请人： Casey Cameron McComas ,  Stephen Todd Cohn ,  Andrew Fensome ,  Joel Adam Goldberg ,  Charles William Mann ,  Michael Anthony Marella ,  David John O'Neill ,  Joseph Peter Sabatucci ,  Eugene Anthony Terefenko ,  Eugene John Trybulski ,  An Thien Vu ,  Richard Page Woodworth, JR. ,  Puwen Zhang

发明人： Casey Cameron McComas ,  Stephen Todd Cohn ,  Andrew Fensome ,  Joel Adam Goldberg ,  Charles William Mann ,  Michael Anthony Marella ,  David John O'Neill ,  Joseph Peter Sabatucci ,  Eugene Anthony Terefenko ,  Eugene John Trybulski ,  An Thien Vu ,  Richard Page Woodworth, JR. ,  Puwen Zhang

IPC分类号： A61K31/5377 ,  C07D285/14 ,  C07D417/06 ,  A61K31/41 ,  A61K31/454 ,  A61P15/00 ,  A61P1/00 ,  A61P25/00 ,  A61P7/12

CPC分类号： C07D417/04 ,  C07D285/14 ,  C07D417/06

摘要： The present invention is directed to aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

摘要翻译： 本发明涉及式I的芳基磺酰胺衍生物：或其药学上可接受的盐，立体异构体或互变异构体，其是单胺再摄取抑制剂，含有这些衍生物的组合物，及其用于预防和治疗病症的方法， 尤其是血管舒缩症状，性功能障碍，胃肠道疾病和泌尿生殖器疾病，抑郁症，内源性行为障碍，认知障碍，糖尿病性神经病，疼痛和其它疾病或病症。

公开(公告)号：US07601722B2

公开(公告)日：2009-10-13

申请号：US11955018

申请日：2007-12-12

申请人： Casey Cameron McComas ,  Stephen Todd Cohn ,  Andrew Fensome ,  Joel Adam Goldberg ,  Charles William Mann ,  Michael Anthony Marella ,  David John O'Neill ,  Joseph Peter Sabatucci ,  Eugene Anthony Terefenko ,  Eugene John Trybulski ,  An Thien Vu ,  Richard Page Woodworth, Jr. ,  Puwen Zhang

发明人： Casey Cameron McComas ,  Stephen Todd Cohn ,  Andrew Fensome ,  Joel Adam Goldberg ,  Charles William Mann ,  Michael Anthony Marella ,  David John O'Neill ,  Joseph Peter Sabatucci ,  Eugene Anthony Terefenko ,  Eugene John Trybulski ,  An Thien Vu ,  Richard Page Woodworth, Jr. ,  Puwen Zhang

IPC分类号： A61K31/496 ,  A61K31/5377 ,  C07D413/06 ,  C07D403/06

CPC分类号： C07D417/04 ,  C07D285/14 ,  C07D417/06

摘要： The present invention is directed to aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

摘要翻译： 本发明涉及式I的芳基磺酰胺衍生物：或其药学上可接受的盐，立体异构体或互变异构体，其是单胺再摄取抑制剂，含有这些衍生物的组合物，及其用于预防和治疗病症的方法， 尤其是血管舒缩症状，性功能障碍，胃肠道疾病和泌尿生殖器疾病，抑郁症，内源性行为障碍，认知障碍，糖尿病性神经病，疼痛和其它疾病或病症。

公开(公告)号：US20080194654A1

公开(公告)日：2008-08-14

申请号：US11955204

申请日：2007-12-12

申请人： Casey Cameron McComas ,  Andrew Fensome ,  Joel Adam Goldberg ,  Charles William Mann ,  David John O'Neill ,  Joseph Peter Sabatucci ,  Eugene Anthony Terefenko ,  Eugene John Trybulski ,  An Thien Vu ,  Puwen Zhang

发明人： Casey Cameron McComas ,  Andrew Fensome ,  Joel Adam Goldberg ,  Charles William Mann ,  David John O'Neill ,  Joseph Peter Sabatucci ,  Eugene Anthony Terefenko ,  Eugene John Trybulski ,  An Thien Vu ,  Puwen Zhang

IPC分类号： A61K31/433 ,  C07D285/14 ,  A61P15/00 ,  A61P1/00 ,  A61P21/00 ,  A61P25/24 ,  A61P7/12 ,  A61P29/00

CPC分类号： C07D417/04 ,  C07D285/14 ,  C07D417/06

摘要： The present invention is directed to hydroxy-substituted aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

摘要翻译： 本发明涉及式I的羟基取代的芳基磺酰胺衍生物：或其药学上可接受的盐，立体异构体或互变异构体，它们是单胺再摄取抑制剂，含有这些衍生物的组合物及其用于预防和治疗病症的方法 ，包括血管舒缩症状，性功能障碍，胃肠道疾病和泌尿生殖器疾病，抑郁症，内源性行为障碍，认知障碍，糖尿病性神经病，疼痛和其他疾病或病症。

公开(公告)号：US20080161366A1

公开(公告)日：2008-07-03

申请号：US11955195

申请日：2007-12-12

申请人： Casey Cameron McComas ,  Stephen Todd Cohn ,  Matthew Lantz Crawley ,  Andrew Fensome ,  Joel Adam Goldberg ,  Douglas John Jenkins ,  Callain Younghee Kim ,  Paige Erin Mahaney ,  Charles William Mann ,  Michael Anthony Marella ,  David John O'Neill ,  Joseph Peter Sabatucci ,  Eugene Anthony Terefenko ,  Eugene John Trybulski ,  An Thien Vu ,  Richard Page Woodworth ,  Puwen Zhang

发明人： Casey Cameron McComas ,  Stephen Todd Cohn ,  Matthew Lantz Crawley ,  Andrew Fensome ,  Joel Adam Goldberg ,  Douglas John Jenkins ,  Callain Younghee Kim ,  Paige Erin Mahaney ,  Charles William Mann ,  Michael Anthony Marella ,  David John O'Neill ,  Joseph Peter Sabatucci ,  Eugene Anthony Terefenko ,  Eugene John Trybulski ,  An Thien Vu ,  Richard Page Woodworth ,  Puwen Zhang

IPC分类号： A61K31/433 ,  C07D285/14 ,  A61P15/00 ,  A61P25/00 ,  A61P1/00 ,  A61P3/00

CPC分类号： C07D417/04 ,  C07D285/14 ,  C07D417/06

摘要： The present invention is directed to aminoalkyl-substituted aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

摘要翻译： 本发明涉及式I的氨基烷基取代的芳基磺酰胺衍生物：或其药学上可接受的盐，立体异构体或互变异构体，它们是单胺再摄取抑制剂，含有这些衍生物的组合物及其用于预防和治疗病症的方法 ，包括血管舒缩症状，性功能障碍，胃肠道疾病和泌尿生殖器疾病，抑郁症，内源性行为障碍，认知障碍，糖尿病性神经病，疼痛和其他疾病或病症。

公开(公告)号：US20080167303A1

公开(公告)日：2008-07-10

申请号：US11955018

申请日：2007-12-12

申请人： Casey Cameron McComas ,  Stephen Todd Cohn ,  Andrew Fensome ,  Joel Adam Golderg ,  Charles William Mann ,  Michael Anthony Marella ,  David John O'Neill ,  Joseph Peter Sabatucci ,  Eugene Anthony Terefenko ,  Eugene John Trybulski ,  An Thien Vu ,  Richard Page Woodworth ,  Puwen Zhang

发明人： Casey Cameron McComas ,  Stephen Todd Cohn ,  Andrew Fensome ,  Joel Adam Golderg ,  Charles William Mann ,  Michael Anthony Marella ,  David John O'Neill ,  Joseph Peter Sabatucci ,  Eugene Anthony Terefenko ,  Eugene John Trybulski ,  An Thien Vu ,  Richard Page Woodworth ,  Puwen Zhang

IPC分类号： A61K31/5377 ,  C07D285/06 ,  A61K31/433 ,  A61K31/496 ,  A61P13/00 ,  A61P25/02 ,  A61P25/00 ,  A61P15/00 ,  C07D403/06 ,  C07D417/06

CPC分类号： C07D417/04 ,  C07D285/14 ,  C07D417/06

摘要： The present invention is directed to aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

摘要翻译： 本发明涉及式I的芳基磺酰胺衍生物：或其药学上可接受的盐，立体异构体或互变异构体，其是单胺再摄取抑制剂，含有这些衍生物的组合物，及其用于预防和治疗病症的方法， 尤其是血管舒缩症状，性功能障碍，胃肠道疾病和泌尿生殖器疾病，抑郁症，内源性行为障碍，认知障碍，糖尿病性神经病，疼痛和其它疾病或病症。

公开(公告)号：US20090093469A1

公开(公告)日：2009-04-09

申请号：US12335245

申请日：2008-12-15

申请人： Callain Younghee Kim ,  Paige Erin Mahaney ,  Eugene John Trybulski ,  Puwen Zhang ,  Eugene Anthony Terefenko ,  Casey Cameron McComas ,  Michael Anthony Marella ,  Richard Dale Coghlan ,  Gavin David Heffernan ,  Stephen Todd Cohn ,  An Thien Vu ,  Joseph Peter Sabatucci ,  Fei Ye

发明人： Callain Younghee Kim ,  Paige Erin Mahaney ,  Eugene John Trybulski ,  Puwen Zhang ,  Eugene Anthony Terefenko ,  Casey Cameron McComas ,  Michael Anthony Marella ,  Richard Dale Coghlan ,  Gavin David Heffernan ,  Stephen Todd Cohn ,  An Thien Vu ,  Joseph Peter Sabatucci ,  Fei Ye

IPC分类号： A61K31/5415 ,  C07D403/06 ,  A61K31/496 ,  C07D413/06 ,  A61K31/5377 ,  C07D209/04 ,  A61K31/404 ,  C07D401/06 ,  A61K31/4439 ,  A61K31/454 ,  C07D265/36 ,  A61K31/538 ,  C07D241/38 ,  A61K31/498 ,  C07D235/04 ,  A61K31/4184 ,  C07D471/04 ,  A61K31/437 ,  A61P29/00 ,  A61P25/00 ,  A61P25/24 ,  C07D409/06 ,  C07D209/96 ,  C07D279/16

CPC分类号： C07D209/08 ,  C07D209/30 ,  C07D209/42 ,  C07D235/06 ,  C07D241/42 ,  C07D265/36 ,  C07D471/04

摘要： The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

公开(公告)号：US20090099164A1

公开(公告)日：2009-04-16

申请号：US12335144

申请日：2008-12-15

申请人： Callain Younghee Kim ,  Paige Erin Mahaney ,  Eugene John Trybulski ,  Puwen Zhang ,  Eugene Anthony Terefenko ,  Casey Cameron McComas ,  Michael Anthony Marella ,  Richard Dale Coghlan ,  Gavin David Heffernan ,  Stephen Todd Cohn ,  An Thien Vu ,  Joseph Peter Sabatucci ,  Fei Ye

发明人： Callain Younghee Kim ,  Paige Erin Mahaney ,  Eugene John Trybulski ,  Puwen Zhang ,  Eugene Anthony Terefenko ,  Casey Cameron McComas ,  Michael Anthony Marella ,  Richard Dale Coghlan ,  Gavin David Heffernan ,  Stephen Todd Cohn ,  An Thien Vu ,  Joseph Peter Sabatucci ,  Fei Ye

IPC分类号： A61K31/538 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/498 ,  A61K31/437 ,  A61P25/24 ,  A61P15/00 ,  A61P1/00 ,  A61P25/22 ,  A61P29/00 ,  A61K31/4184 ,  A61K31/404 ,  A61K31/4439

CPC分类号： C07D209/08 ,  C07D209/30 ,  C07D209/42 ,  C07D235/06 ,  C07D241/42 ,  C07D265/36 ,  C07D471/04

摘要： The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

摘要翻译： 本发明涉及式I的苯基氨基丙醇衍生物：或其药学上可接受的盐，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，所述方法尤其包括血管舒缩症状（VMS） 特别是选自重度抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛等的那些情况，特别是选自以下的那些病症：血管紧张素转换酶，抑制性功能障碍，性功能障碍，胃肠道和泌尿生殖系统疾病，慢性疲劳综合征，纤维瘤病综合征，神经系统疾病及其组合， 糖尿病性神经病变及其组合。

公开(公告)号：US07601744B2

公开(公告)日：2009-10-13

申请号：US11528792

申请日：2006-09-27

申请人： Casey Cameron McComas ,  Puwen Zhang ,  Eugene John Trybulski ,  An Thien Vu ,  Eugene Anthony Terefenko

发明人： Casey Cameron McComas ,  Puwen Zhang ,  Eugene John Trybulski ,  An Thien Vu ,  Eugene Anthony Terefenko

IPC分类号： A61K31/41 ,  C07D285/06

CPC分类号： C07D285/14

摘要： The present invention is directed to benzothiadiazolylphenylalkylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

摘要翻译： 本发明涉及式I的苯并噻二唑基苯基烷基胺衍生物：或其药学上可接受的盐，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，所述方法尤其包括血管舒缩症状（VMS） 特别是选自重症抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛等的那些病症，其中，所述疾病，性功能障碍，胃肠道和泌尿生殖系统疾病，慢性疲劳综合征，纤维肌痛综合征，神经系统疾病及其组合， 糖尿病性神经病变及其组合。

公开(公告)号：US07517899B2

公开(公告)日：2009-04-14

申请号：US11091885

申请日：2005-03-28

申请人： Callain Younghee Kim ,  Paige Erin Mahaney ,  Eugene John Trybulski ,  Puwen Zhang ,  Eugene Anthony Terefenko ,  Casey McComas ,  Michael Anthony Marella ,  Richard Dale Coghlan ,  Gavin David Heffernan ,  Stephen Todd Cohn ,  An Thien Vu ,  Joseph Peter Sabatucci ,  Fei Ye

发明人： Callain Younghee Kim ,  Paige Erin Mahaney ,  Eugene John Trybulski ,  Puwen Zhang ,  Eugene Anthony Terefenko ,  Casey McComas ,  Michael Anthony Marella ,  Richard Dale Coghlan ,  Gavin David Heffernan ,  Stephen Todd Cohn ,  An Thien Vu ,  Joseph Peter Sabatucci ,  Fei Ye

IPC分类号： A61K31/40 ,  A61K31/415 ,  C07D235/00 ,  C07D209/04

CPC分类号： C07D209/08 ,  C07D209/30 ,  C07D209/42 ,  C07D235/06 ,  C07D241/42 ,  C07D265/36 ,  C07D471/04

摘要： The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

摘要翻译： 本发明涉及式I的苯基氨基丙醇衍生物：或其药学上可接受的盐，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，所述方法尤其包括血管舒缩症状（VMS） 特别是选自重度抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛等的那些情况，特别是选自以下的那些病症：血管紧张素转换酶，抑制性功能障碍，性功能障碍，胃肠道和泌尿生殖系统疾病，慢性疲劳综合征，纤维瘤病综合征，神经系统疾病及其组合， 糖尿病性神经病变及其组合。

公开(公告)号：US20080085938A1

公开(公告)日：2008-04-10

申请号：US11866158

申请日：2007-10-02

申请人： An Thien Vu ,  Stephen Todd Cohn ,  Eugene Anthony Terefenko ,  William Jay Moore ,  Puwen Zhang ,  Paige Erin Mahaney ,  Eugene John Trybulski

发明人： An Thien Vu ,  Stephen Todd Cohn ,  Eugene Anthony Terefenko ,  William Jay Moore ,  Puwen Zhang ,  Paige Erin Mahaney ,  Eugene John Trybulski

IPC分类号： A61K31/136 ,  A61P1/00 ,  A61P13/00 ,  A61P15/00 ,  A61P25/00 ,  C07C211/44

CPC分类号： C07C215/28 ,  C07C217/64 ,  C07C217/84

摘要： The present invention is directed to arylamino-arylpropanolamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

摘要翻译： 本发明涉及式I的芳基氨基 - 芳基丙醇胺衍生物：或其药学上可接受的盐，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，所述方法尤其包括血管舒缩症状（ VMS），性功能障碍，胃肠道和泌尿生殖系统疾病，慢性疲劳综合征，纤维肌痛综合征，神经系统疾病及其组合，特别是选自重度抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛， 疼痛，糖尿病性神经病，及其组合。