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1.
公开(公告)号:US07892802B2
公开(公告)日:2011-02-22
申请号:US12252988
申请日:2008-10-16
发明人: Heinz Redl , Guenther Schlag , Johann Eibl
IPC分类号: C12N9/00
CPC分类号: A61L24/106
摘要: The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.
摘要翻译: 本发明提供含有弹性蛋白酶抑制剂的纤维蛋白原组织粘合剂。
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公开(公告)号:US07091015B1
公开(公告)日:2006-08-15
申请号:US09486516
申请日:1998-08-26
申请人: Heinz Redl , Guenther Schlag , Johann Eibl
发明人: Heinz Redl , Guenther Schlag , Johann Eibl
IPC分类号: C12N9/00
CPC分类号: A61L24/106
摘要: The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.
摘要翻译: 本发明提供含有弹性蛋白酶抑制剂的纤维蛋白原组织粘合剂。
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公开(公告)号:US4735616A
公开(公告)日:1988-04-05
申请号:US875080
申请日:1986-06-17
申请人: Johann Eibl , Thomas Seelich , Heinz Redl , Georg Habison
发明人: Johann Eibl , Thomas Seelich , Heinz Redl , Georg Habison
CPC分类号: A61B17/00491 , A61M5/19 , A61B2017/00495 , A61M5/284
摘要: An arrangement for applying a tissue adhesive based on human or animal proteins, to seamlessly or seam-supportingly connect human or animal tissue or organ parts by uniting with blood-clot-promoting coagulation factors (thrombin). The arrangement includes a plurality of syringe bodies commonly actuatable by pistons and to which a connecting head is attachable. The syringe bodies have equal effective strokes, yet one of them, i.e., that destined to contain the protein solution, has a cross sectional area that is two to nine times larger than the other one(s). There may be applied tissue adhesives having a fibrinogen content of from 2 to 12%.
摘要翻译: 用于施加基于人或动物蛋白质的组织粘合剂的装置,通过与促凝血促凝血因子(凝血酶)结合而无缝地或缝合地连接人或动物组织或器官部分。 该装置包括通常由活塞致动的多个注射器体,并且可连接头部。 注射器本体具有相同的有效冲程,但是其中一个,即注定含有蛋白质溶液的横截面面积的横截面面积比另一个的横截面积大2至9倍。 可以使用纤维蛋白原含量为2至12%的组织粘合剂。
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4.
公开(公告)号:US08425947B2
公开(公告)日:2013-04-23
申请号:US13021551
申请日:2011-02-04
申请人: Heinz Redl , Johann Eibl , Irmgard Schlag
发明人: Heinz Redl , Guenther Schlag , Johann Eibl
IPC分类号: A01N65/00
CPC分类号: A61L24/106
摘要: The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.
摘要翻译: 本发明提供含有弹性蛋白酶抑制剂的纤维蛋白原组织粘合剂。
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5.
公开(公告)号:US07459295B2
公开(公告)日:2008-12-02
申请号:US11443925
申请日:2006-05-30
申请人: Heinz Redl , Gunther Schlag , Johann Eibl
发明人: Heinz Redl , Gunther Schlag , Johann Eibl
IPC分类号: C12N9/00
CPC分类号: A61L24/106
摘要: The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.
摘要翻译: 本发明提供含有弹性蛋白酶抑制剂的纤维蛋白原组织粘合剂。
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公开(公告)号:US20090275011A1
公开(公告)日:2009-11-05
申请号:US12368010
申请日:2009-02-09
申请人: Johann Eibl , Heinz Redl
发明人: Johann Eibl , Heinz Redl
IPC分类号: A01N1/02
CPC分类号: C12N5/0605
摘要: Sterile, virally safe, heterologous, homologous, isologous or autologous tissue, tissue-typed or not tissue-typed, which contains predifferentiated and/or differentiable sessile stem cells and which can be used for wound closure and/or promotion of wound healing.
摘要翻译: 无菌,病毒安全,异源,同源,异源或自体组织,组织型或非组织型组织型,其含有预分化和/或可分化的无柄干细胞,其可用于伤口闭合和/或促进伤口愈合。
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7.
公开(公告)号:US20090041748A1
公开(公告)日:2009-02-12
申请号:US12252988
申请日:2008-10-16
申请人: Heinz Redl , Guenther Schlag , Irmgard Schlag , Johann Eibl
发明人: Heinz Redl , Guenther Schlag , Irmgard Schlag , Johann Eibl
CPC分类号: A61L24/106
摘要: The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.
摘要翻译: 本发明提供含有弹性蛋白酶抑制剂的纤维蛋白原组织粘合剂。
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公开(公告)号:US20060216280A1
公开(公告)日:2006-09-28
申请号:US11443925
申请日:2006-05-30
申请人: Heinz Redl , Guenther Schlag , Johann Eibl
发明人: Heinz Redl , Guenther Schlag , Johann Eibl
CPC分类号: A61L24/106
摘要: The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.
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公开(公告)号:US20120316113A1
公开(公告)日:2012-12-13
申请号:US13462624
申请日:2012-05-02
申请人: Heinz Redl , Tatjana Morton
发明人: Heinz Redl , Tatjana Morton
CPC分类号: C07K14/503 , A61K38/1825 , C07K2319/21 , C07K2319/23 , C07K2319/50
摘要: The present invention relates to a polypeptide fragments of Fibroblast Growth Factor 2, wherein said fragments are adapted to bind to fibrinogen or to fibrin and/or increase cell proliferation, differentiation or migration. These fragments are suitable for promoting wound healing and/or hemostasis.
摘要翻译: 本发明涉及成纤维细胞生长因子2的多肽片段,其中所述片段适于结合纤维蛋白原或纤维蛋白和/或增加细胞增殖,分化或迁移。 这些片段适用于促进伤口愈合和/或止血。
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公开(公告)号:US20100168779A1
公开(公告)日:2010-07-01
申请号:US12650185
申请日:2009-12-30
申请人: Heinz Redl , Zafar Khakpour , Rene Fortelny
发明人: Heinz Redl , Zafar Khakpour , Rene Fortelny
CPC分类号: A61B17/00491 , A61B17/3474 , A61B2017/00495 , A61B2017/00522
摘要: A laparoscopic tissue sealant spray apparatus and system having a laparoscopic tissue sealant spray assembly combined with a trocar assembly, the tissue sealant spray assembly having an elongate delivery tube. A spray outlet at a distal end of the elongate delivery tube may be rounded or angled. A ring member provided at the distal end of the elongate delivery tube directs a spray cone toward a portion of a target tissue site, and the spray cone may be repositioned to a different portion of the target tissue site by rotation of the elongate delivery tube. The trocar assembly includes a vent opening that connects to a venting valve member that provides a vent path which passively opens upon operation of the tissue sealant spray assembly, avoiding excessive pressure build-up within a body cavity.
摘要翻译: 一种腹腔镜组织密封剂喷雾装置和系统,其具有与套管针组件结合的腹腔镜组织密封剂喷涂组件,所述组织密封剂喷涂组件具有细长的输送管。 在细长输送管的远端处的喷雾出口可以是圆形的或成角度的。 设置在细长输送管的远端处的环形构件将喷雾锥体朝向目标组织部位的一部分引导,并且可以通过细长输送管的旋转将喷雾锥体重新定位到目标组织部位的不同部分。 套管针组件包括连接到通气阀构件的通气口,该通气孔构件提供在组织密封剂喷涂组件的操作时被动打开的通气路径,从而避免体腔内过度的压力积聚。
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