公开(公告)号：US5258392A

公开(公告)日：1993-11-02

申请号：US830107

申请日：1992-01-31

申请人： Johannes H. Wieringa ,  Sjoerd F. van Aelst ,  Ralf Plate

发明人： Johannes H. Wieringa ,  Sjoerd F. van Aelst ,  Ralf Plate

IPC分类号： A61K31/435 ,  A61P25/28 ,  C07D453/02 ,  A61K31/445

CPC分类号： C07D453/02 ,  Y10S514/879

摘要： The invention relates to a 3-quinuclidine derivative having the formula I ##STR1## wherein X is O or S, and R represents one to five substituents independently selected from hydrogen, hydroxy, lower alkyl, lower alkoxy, lower aralkyloxy, lower alkanoyloxy, halogen, NO.sub.2, CF.sub.3, CN, NR.sub.1 R.sub.2, and COR.sub.3, in which R.sub.1 and R.sub.2 are independently selected from hydrogen, lower alkyl, and lower alkanoyl, and R.sub.3 is selected from OH, lower alkyl, lower alkoxy, and NR.sub.4 R.sub.5, wherein R.sub.4 and R.sub.5 are independently hydrogen or lower alkyl; or pharmaceutically acceptable salts thereof.