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公开(公告)号：US08540895B2
公开(公告)日：2013-09-24
申请号：US13177275
申请日：2011-07-06
CPC分类号： C01B11/024 , A61L2/18 , A61L2/20
摘要： A composition for generating chlorine dioxide comprises active ingredients, a suitable hydrophobic compound, and a suitable super absorbent compound. A suitable hydrophobic compound will, among other characteristics, repel the solvent for at least the initial 30 seconds of exposure thereto. A suitable super absorbent compound will, among other characteristics, absorb at least 75 times its weight in solvent and will not gel until the chlorine-dioxide generating reaction is substantially complete.
摘要翻译： 用于产生二氧化氯的组合物包括活性成分，合适的疏水性化合物和合适的超吸收性化合物。 除了其它特征之外，合适的疏水性化合物将排斥溶剂至少暴露于其中的初始30秒。 除了其它特征之外，合适的超吸收性化合物将在溶剂中吸收至少75倍的重量，并且不会凝胶化，直到二氧化氯产生反应基本上完成。
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公开(公告)号：US20110309297A1
公开(公告)日：2011-12-22
申请号：US13177275
申请日：2011-07-06
IPC分类号： C09K3/00
CPC分类号： C01B11/024 , A61L2/18 , A61L2/20
摘要： A composition for generating chlorine dioxide comprises active ingredients, a suitable hydrophobic compound, and a suitable super absorbent compound. A suitable hydrophobic compound will, among other characteristics, repel the solvent for at least the initial 30 seconds of exposure thereto. A suitable super absorbent compound will, among other characteristics, absorb at least 75 times its weight in solvent and will not gel until the chlorine-dioxide generating reaction is substantially complete.
摘要翻译： 用于产生二氧化氯的组合物包括活性成分，合适的疏水性化合物和合适的超吸收性化合物。 除了其它特征之外，合适的疏水性化合物将排斥溶剂至少暴露于其中的初始30秒。 除了其它特征之外，合适的超吸收性化合物将在溶剂中吸收至少75倍的重量，并且不会凝胶化，直到二氧化氯产生反应基本上完成。
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公开(公告)号：US20150083963A1
公开(公告)日：2015-03-26
申请号：US14033833
申请日：2013-09-23
IPC分类号： C01B11/02
CPC分类号： C01B11/024 , A61L2/00 , A61L2/18 , A61L2/20
摘要： A composition for generating chlorine dioxide comprises active ingredients, a suitable hydrophobic compound, and a suitable super absorbent compound. A suitable hydrophobic compound will, among other characteristics, repel the solvent for at least the initial 30 seconds of exposure thereto. A suitable super absorbent compound will, among other characteristics, absorb at least 75 times its weight in solvent and will not gel until the chlorine-dioxide generating reaction is substantially complete.
摘要翻译： 用于产生二氧化氯的组合物包括活性成分，合适的疏水性化合物和合适的超吸收性化合物。 除了其它特征之外，合适的疏水性化合物将排斥溶剂至少暴露于其中的初始30秒。 除了其它特征之外，合适的超吸收性化合物将在溶剂中吸收至少75倍的重量，并且不会凝胶化，直到二氧化氯产生反应基本上完成。
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公开(公告)号：US20120322762A1
公开(公告)日：2012-12-20
申请号：US13592228
申请日：2012-08-22
申请人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
发明人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
IPC分类号： A61K31/69
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/19 , A61K31/4965 , A61K31/69 , A61K47/10 , C07B63/04
摘要： Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.
摘要翻译： 硼替佐米的多剂量制剂被提出，其中硼替佐米具有显着改善的稳定性。 特别优选的制剂包括硼替佐米是适合注射的液体形式的制剂，其中溶剂体系主要包含丙二醇。 在其他优选方面，硼替佐米作为具有异双功能路易斯碱的路易斯供体 - 受体复合物存在。
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公开(公告)号：US08263578B2
公开(公告)日：2012-09-11
申请号：US13431313
申请日：2012-03-27
申请人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
发明人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
IPC分类号： A01N55/08 , A61K31/69 , A61K31/4965 , C07F5/02 , C07F5/04 , C07F7/02 , C07D241/00 , C07D241/02
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/19 , A61K31/4965 , A61K31/69 , A61K47/10 , C07B63/04
摘要： Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.
摘要翻译： 硼替佐米的多剂量制剂被提出，其中硼替佐米具有显着改善的稳定性。 特别优选的制剂包括硼替佐米是适合注射的液体形式的制剂，其中溶剂体系主要包含丙二醇。 在其他优选方面，硼替佐米作为具有异双功能路易斯碱的路易斯供体 - 受体复合物存在。
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公开(公告)号：US09180093B2
公开(公告)日：2015-11-10
申请号：US13592235
申请日：2012-08-22
申请人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
发明人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/19 , A61K31/4965 , A61K31/69 , A61K47/10 , C07B63/04
摘要： Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.
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公开(公告)号：US20110230441A1
公开(公告)日：2011-09-22
申请号：US13051102
申请日：2011-03-18
申请人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
发明人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
CPC分类号： A61K31/69 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/4965 , A61K47/10
摘要： Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.
摘要翻译： 硼替佐米的多剂量制剂被提出，其中硼替佐米具有显着改善的稳定性。 特别优选的制剂包括硼替佐米是适合注射的液体形式的制剂，其中溶剂体系主要包含丙二醇。 在其他优选方面，硼替佐米作为具有异双功能路易斯碱的路易斯供体 - 受体复合物存在。
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公开(公告)号：US09107821B2
公开(公告)日：2015-08-18
申请号：US13592228
申请日：2012-08-22
申请人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
发明人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/19 , A61K31/4965 , A61K31/69 , A61K47/10 , C07B63/04
摘要： Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.
摘要翻译： 硼替佐米的多剂量制剂被提出，其中硼替佐米具有显着改善的稳定性。 特别优选的制剂包括硼替佐米是适合注射的液体形式的制剂，其中溶剂体系主要包含丙二醇。 在其他优选方面，硼替佐米作为具有异双功能路易斯碱的路易斯供体 - 受体复合物存在。
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公开(公告)号：US20120322763A1
公开(公告)日：2012-12-20
申请号：US13592235
申请日：2012-08-22
申请人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
发明人： Kumaresh Soppimath , Satish Pejaver , Kanaiyalal R. Patel , Lakkaraju Dasaradhi , Rama Sodum , Hari Desu , Navneet Puri
IPC分类号： A61K31/69
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/19 , A61K31/4965 , A61K31/69 , A61K47/10 , C07B63/04
摘要： Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.
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10.发明申请Methods and Solid Compositions for Generating Soapy and Non-Soapy Aqueous Solutions Containing Free Chlorine Dioxide 审中-公开用于产生含有游离二氧化氯的肥皂和非肥皂水溶液的方法和固体组合物公开(公告)号：US20080067470A1
公开(公告)日：2008-03-20
申请号：US11854434
申请日：2007-09-12
IPC分类号： C09K3/00
CPC分类号： C01B11/024 , A61L2/18 , A61L2/20
摘要： Some embodiments of the invention provide solid compositions that, when exposed to or otherwise placed in an aqueous solution, will release chlorine dioxide and surfactants, producing a soapy, aqueous solution containing chlorine dioxide. These solid compositions comprise an alkali chlorite salt, a solid acid source, and a surfactant. In some other embodiments, the solid compositions produce a non-soapy aqueous solution containing chlorine dioxide. These solid compositions comprise an alkali chlorite salt and a solid acid source.
摘要翻译： 本发明的一些实施方案提供固体组合物，当暴露于或以其它方式置于水溶液中时，将释放二氧化氯和表面活性剂，产生含有二氧化氯的肥皂水溶液。 这些固体组合物包含碱式亚氯酸盐，固体酸源和表面活性剂。 在一些其它实施方案中，固体组合物产生含有二氧化氯的非肥皂水溶液。 这些固体组合物包含碱式亚氯酸盐和固体酸源。
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