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公开(公告)号：US20050238673A1
公开(公告)日：2005-10-27
申请号：US10834816
申请日：2004-04-27
IPC分类号： A61K9/107 , A61K31/337 , A61K31/704 , A61K38/13 , A61K47/12
CPC分类号： A61K31/337 , A61K9/1075 , A61K31/7048 , A61K47/12
摘要： This invention concerns novel methods of enhancing the solubility of a compound. Compositions prepared using such methods are also disclosed. Compositions prepared using the methods have various advantages over conventionally known compositions.
摘要翻译： 本发明涉及提高化合物溶解度的新方法。 还公开了使用这些方法制备的组合物。 使用该方法制备的组合物具有优于常规已知组合物的各种优点。
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公开(公告)号：US20070031460A1
公开(公告)日：2007-02-08
申请号：US11546618
申请日：2006-10-11
IPC分类号： A61K9/00
CPC分类号： A61K31/337 , A61K9/1075 , A61K31/7048 , A61K47/12
摘要： This invention concerns novel methods of enhancing the solubility of a compound. Compositions prepared using such methods are also disclosed. Compositions prepared using the methods have various advantages over conventionally known compositions.
摘要翻译： 本发明涉及提高化合物溶解度的新方法。 还公开了使用这些方法制备的组合物。 使用该方法制备的组合物具有优于常规已知组合物的各种优点。
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公开(公告)号：US20070048332A1
公开(公告)日：2007-03-01
申请号：US11362267
申请日：2006-02-24
申请人： Cynthia Oliver , Erica Shane , Benjamin Isaacs , Christian Allan , Stephen Chang
发明人： Cynthia Oliver , Erica Shane , Benjamin Isaacs , Christian Allan , Stephen Chang
CPC分类号： C07K16/1027 , A61K9/0019 , A61K9/0043 , A61K39/39591 , A61K39/42 , A61K47/183 , A61K47/22 , A61K47/26 , A61K2039/505 , A61K2039/54 , C07K16/00 , C07K2317/24 , C07K2317/565 , C07K2317/94
摘要： The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention.
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公开(公告)号：US20060034827A1
公开(公告)日：2006-02-16
申请号：US10461904
申请日：2003-06-13
申请人： Cynthia Oliver , Erica Shane , Benjamin Isaacs , Christian Allan , Stephen Chang
发明人： Cynthia Oliver , Erica Shane , Benjamin Isaacs , Christian Allan , Stephen Chang
IPC分类号： A61K39/395
CPC分类号： C07K16/1027 , A61K9/0019 , A61K9/0043 , A61K39/39591 , A61K39/42 , A61K47/183 , A61K47/22 , A61K47/26 , A61K2039/505 , A61K2039/54 , C07K16/00 , C07K2317/24 , C07K2317/565 , C07K2317/94
摘要： The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention.
摘要翻译： 本发明提供了免疫特异性结合呼吸道合胞病毒（RSV）抗原的SYNAGIS或其抗原结合片段的液体制剂，该制剂表现出稳定性，低至不可检测的聚集水平，以及很少甚至没有损失 SYNAGIS或其抗原结合片段的生物活性，甚至在长时间的储存期间。 特别地，本发明提供了SYNAGIS或其抗原结合片段的液体制剂，其免疫特异性结合RSV抗原，该制剂基本上不含表面活性剂，无机盐和/或其它常见赋形剂。 此外，本发明提供使用本发明的液体制剂预防，治疗或改善与RSV感染相关的症状的方法。
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