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公开(公告)号:US20190209674A1
公开(公告)日:2019-07-11
申请号:US16334441
申请日:2017-09-19
申请人: David WEINER , Karuppiah MUTHUMANI , Jian YAN
发明人: David WEINER , Karuppiah MUTHUMANI , Jian YAN
CPC分类号: A61K39/12 , A61K31/7088 , A61K39/42 , A61K2039/505 , A61K2039/53 , A61P31/14 , C07K14/18 , C07K16/10 , C07K16/1081 , C07K2317/56 , C12N7/00 , C12N2770/24134 , C12N2770/24171 , Y02A50/392 , Y02A50/401 , A61K2300/00
摘要: Disclosed herein is a composition comprising a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen, and functional fragments thereof. The invention also relates to a composition comprising the combination of a first composition that elicits an immune response in a mammal against zika virus and a second composition comprising a recombinant nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof. In some instances, the nucleic acid molecule comprises a nucleotide sequence encoding an anti-ZIKV-Envelope (anti-ZIKV E) Protein antibody.
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公开(公告)号:US20190192535A1
公开(公告)日:2019-06-27
申请号:US16145768
申请日:2018-09-28
发明人: Brian C. Shook , In Jong Kim , Thomas P. Blaisdell , Jianming Yu , Joseph Panarese , Kai Lin , Michael H.J. Rhodin , Nicole V. McAllister , Yat Sun Or
IPC分类号: A61K31/5513 , A61P31/14
CPC分类号: A61K31/5513 , A61K31/4439 , A61K31/7056 , A61K39/395 , A61K39/42 , A61K45/06 , A61P31/14 , C07D213/12 , C07D213/14 , C07D217/12 , C07D217/14 , C07D243/24 , C07D403/12 , C07D491/04 , C07D498/08 , C07K16/1027 , C07K2317/24 , C07K2317/76 , A61K2300/00
摘要: The present invention relates to pharmaceutical agents administered to a subject either in combination or in series for the treatment of a Respiratory Syncytial Virus (RSV) infection, wherein treatment comprises administering a compound effective to inhibit the function of the RSV and an additional compound or combinations of compounds having anti-RSV activity.
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公开(公告)号:US20190105384A1
公开(公告)日:2019-04-11
申请号:US15743133
申请日:2015-07-21
IPC分类号: A61K39/12 , A61P35/00 , A61P31/20 , A61K39/395 , A61K39/42 , C07K16/08 , C07K16/28 , C07K16/46 , A61K31/519 , A61K31/4745 , A61K31/7064 , A61K9/00
CPC分类号: A61K39/12 , A61K9/0031 , A61K31/4745 , A61K31/519 , A61K31/7064 , A61K39/395 , A61K39/39558 , A61K39/42 , A61K2039/545 , A61K2039/55 , A61P31/20 , A61P35/00 , C07K16/08 , C07K16/084 , C07K16/28 , C07K16/46 , C12N2710/20034
摘要: The invention relates to methods, compositions, and kits for treating a condition with an immune response modifier and a human papillomavirus (HPV) vaccine. Conditions treatable with the methods, kits and compositions include but are not limited to neoplasia, anal intraepithelial neoplasia, high-grade squamous intraepithelial neoplasia, dysplasia, anal dysplasia, dysplastic lesion, high-grade dysplastic lesion, condyloma, anal cancer, anal tumor, HPV infection, and any HPV-induced condition.
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公开(公告)号:US20180303926A1
公开(公告)日:2018-10-25
申请号:US15569641
申请日:2016-04-29
发明人: Ben Hause , Emily Collin , Ying Fang , Lalitha Peddireddi
IPC分类号: A61K39/12 , C12Q1/70 , A61P31/12 , G01N33/569 , A61K39/42
CPC分类号: A61K39/12 , A61K39/42 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , A61P31/12 , C12N2770/24134 , C12Q1/70 , G01N33/569
摘要: Porcine pestivirus designated herein as atypical porcine pestivirus (“APPV”) (Genbank accession no. KR011347.1). Immunogenic compositions to induce an immune response against porcine pestivirus infection in a pig are described, which APPV antigenic agents (e.g., isolated whole virus, derivatives thereof, functional fragments thereof, and combinations of the foregoing). Methods of vaccinating against porcine pestivirus infection using the immunogenic compositions are also described. The methods can be also applied for clinical research and/or study, including diagnostic methods for detecting pestivirus infection using monoclonal antibodies specifically binding to APPV epitopes.
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公开(公告)号:US20180265565A1
公开(公告)日:2018-09-20
申请号:US15761563
申请日:2016-09-22
IPC分类号: C07K14/73 , C07K14/705 , C07K14/725 , C07K16/10 , A61K35/17 , A61K45/06 , A61K39/42 , A61K38/17 , A61P31/18
CPC分类号: C07K14/70514 , A61K35/17 , A61K38/1774 , A61K39/42 , A61K45/06 , A61K2039/505 , A61K2039/5158 , A61K2039/572 , A61P31/18 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K16/1045 , C07K2317/21 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/33
摘要: The present invention relates to compositions and methods for treating of a HIV infected mammal using a CD4 membrane-bound chimeric receptor or a HIV specific scFvs CARs. One aspect includes a modified T cell and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with HIV infection.
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公开(公告)号:US10072072B2
公开(公告)日:2018-09-11
申请号:US15928566
申请日:2018-03-22
发明人: Kalpit A. Vora , Kara S. Cox , Aimin Tang , Zhifeng Chen , Daniel DiStefano , Lan Zhang , Hua-Poo Su
IPC分类号: A61K39/00 , A61K39/155 , C07K16/10 , A61K39/42 , C07K14/005
CPC分类号: C07K16/1027 , A61K39/42 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
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公开(公告)号:US10072071B2
公开(公告)日:2018-09-11
申请号:US15233026
申请日:2016-08-10
申请人: Humabs BioMed SA
发明人: Davide Corti
IPC分类号: C07K16/10
CPC分类号: C07K16/1027 , A61K39/42 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2760/18522
摘要: The invention relates to antibodies, and antigen binding fragments thereof, that neutralize infection of both RSV, MPV and PVM. The invention also relates to nucleic acids that encode, immortalized B cells and cultured plasma cells that produce, and to polypeptides that bind to such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and polypeptides recognized by the antibodies of the invention in screening methods as well as in the diagnosis, treatment and prevention of RSV or MPV infection and RSV and MPV co-infection.
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公开(公告)号:US20180215809A1
公开(公告)日:2018-08-02
申请号:US15928503
申请日:2018-03-22
发明人: Kalpit A. Vora , Kara S. Cox , Aimin Tang , Zhifeng Chen , Daniel DiStefano , Lan Zhang , Hua-Poo Su
CPC分类号: C07K16/1027 , A61K39/42 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
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公开(公告)号:US20180215808A1
公开(公告)日:2018-08-02
申请号:US15928438
申请日:2018-03-22
发明人: Kalpit A. Vora , Kara S. Cox , Aimin Tang , Zhifeng Chen , Daniel DiStefano , Lan Zhang , Hua-Poo Su
CPC分类号: C07K16/1027 , A61K39/42 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
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公开(公告)号:US10035843B2
公开(公告)日:2018-07-31
申请号:US15042656
申请日:2016-02-12
申请人: MedImmune Limited
发明人: Tim Beaumont , Adrianus Q. Bakker , Etsuko Yasuda
IPC分类号: C07K16/10 , A61K39/42 , A61K31/7088 , A61K39/00
CPC分类号: C07K16/1027 , A61K31/7088 , A61K39/42 , A61K2039/505 , A61K2039/507 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The invention provides antibodies and functional equivalents thereof which are capable of specifically binding RSV. Nucleic acid sequences encoding said antibody, as well as antibody producing cells and methods for producing said antibody are also provided.
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