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1.发明授权公开(公告)号：US08469891B2
公开(公告)日：2013-06-25
申请号：US13029369
申请日：2011-02-17
CPC分类号： A61B8/485 , A61B5/055 , A61B8/08 , A61B8/5261
摘要： A viscoelastic property of tissue is measured in vivo. To collect more information and/or estimate viscosity, shear modulus, and/or other shear characteristics, an amplitude and phase modulated waveform is transmitted to the tissue. The displacement caused by the waveform over time includes displacements associated with response to different frequencies. By examining the displacement in the frequency domain, one or more viscoelastic properties may be calculated for different frequencies. The frequency response may indicate the health of the tissue.
摘要翻译： 在体内测量组织的粘弹性。 为了收集更多信息和/或估计粘度，剪切模量和/或其他剪切特性，幅度和相位调制波形被传送到组织。 由波形随时间引起的位移包括与响应于不同频率相关联的位移。 通过检查频域中的位移，可以针对不同的频率计算一个或多个粘弹性质。 频率响应可能表示组织的健康。
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2.发明申请公开(公告)号：US20140276058A1
公开(公告)日：2014-09-18
申请号：US14020643
申请日：2013-09-06
申请人： Liexiang Fan , John Benson
发明人： Liexiang Fan , John Benson
摘要： Fat fraction is estimated from shear wave propagation. Acoustic radiation force is used to generate a shear wave in tissue of interest. The attenuation, center frequency, bandwidth or other non-velocity characteristic of the shear wave is calculated and used to estimate the fat fraction.
摘要翻译： 从剪切波传播估计脂肪分数。 声辐射力用于在感兴趣的组织中产生剪切波。 计算剪切波的衰减，中心频率，带宽或其他非速度特性，并用于估算脂肪分数。
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3.发明授权公开(公告)号：US09468421B2
公开(公告)日：2016-10-18
申请号：US13533660
申请日：2012-06-26
申请人： John Benson , Liexiang Fan
发明人： John Benson , Liexiang Fan
CPC分类号： A61B8/5223 , A61B8/461 , A61B8/463 , A61B8/485
摘要： Information associated with shear calculation is also displayed in ultrasound shear wave imaging. More information than just a shear wave image is provided for diagnosis. Information about the quality or variables used to determine shear is also displayed. This additional information may assist the user in determining whether the shear information indicates tissue characteristics or unreliable shear calculation.
摘要翻译： 与剪切计算相关的信息也显示在超声剪切波成像中。 提供的信息不仅仅是剪切波图像用于诊断。 还显示有关用于确定剪切的质量或变量的信息。 该附加信息可以帮助用户确定剪切信息是指示组织特征还是不可靠的剪切计算。
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4.发明申请公开(公告)号：US20130218011A1
公开(公告)日：2013-08-22
申请号：US13533660
申请日：2012-06-26
申请人： John Benson , Liexiang Fan
发明人： John Benson , Liexiang Fan
IPC分类号： A61B8/08
CPC分类号： A61B8/5223 , A61B8/461 , A61B8/463 , A61B8/485
摘要： Information associated with shear calculation is also displayed in ultrasound shear wave imaging. More information than just a shear wave image is provided for diagnosis. Information about the quality or variables used to determine shear is also displayed. This additional information may assist the user in determining whether the shear information indicates tissue characteristics or unreliable shear calculation.
摘要翻译： 与剪切计算相关的信息也显示在超声剪切波成像中。 提供的信息不仅仅是剪切波图像用于诊断。 还显示有关用于确定剪切的质量或变量的信息。 该附加信息可以帮助用户确定剪切信息是指示组织特征还是不可靠的剪切计算。
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公开(公告)号：US10743814B2
公开(公告)日：2020-08-18
申请号：US14020643
申请日：2013-09-06
申请人： Liexiang Fan , John Benson
发明人： Liexiang Fan , John Benson
摘要： Fat fraction is estimated from shear wave propagation. Acoustic radiation force is used to generate a shear wave in tissue of interest. The attenuation, center frequency, bandwidth or other non-velocity characteristic of the shear wave is calculated and used to estimate the fat fraction.
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6.发明申请公开(公告)号：US20120215101A1
公开(公告)日：2012-08-23
申请号：US13029369
申请日：2011-02-17
IPC分类号： A61B8/00
CPC分类号： A61B8/485 , A61B5/055 , A61B8/08 , A61B8/5261
摘要： A viscoelastic property of tissue is measured in vivo. To collect more information and/or estimate viscosity, shear modulus, and/or other shear characteristics, an amplitude and phase modulated waveform is transmitted to the tissue. The displacement caused by the waveform over time includes displacements associated with response to different frequencies. By examining the displacement in the frequency domain, one or more viscoelastic properties may be calculated for different frequencies. The frequency response may indicate the health of the tissue.
摘要翻译： 在体内测量组织的粘弹性。 为了收集更多信息和/或估计粘度，剪切模量和/或其他剪切特性，幅度和相位调制波形被传送到组织。 由波形随时间引起的位移包括与响应于不同频率相关联的位移。 通过检查频域中的位移，可以针对不同的频率计算一个或多个粘弹性质。 频率响应可能表示组织的健康。
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公开(公告)号：US10338203B2
公开(公告)日：2019-07-02
申请号：US13229408
申请日：2011-09-09
申请人： Liexiang Fan , Paul Freiburger , John Benson
发明人： Liexiang Fan , Paul Freiburger , John Benson
摘要： Classification preprocessing is provided for medical ultrasound shear wave imaging. In response to stress, the displacement at one or more locations in a patient is measured. The displacement over time is a curve representing a shift in location. One or more characteristics of the curve, such as signal-to-noise ratio and maximum displacement, are used to classify the location. The location is classified as fluid or fluid tissue, solid tissue, or non-determinative. Subsequent shear imaging may provide shear information for locations of solid tissue and not at other locations.
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公开(公告)号：US20130066204A1
公开(公告)日：2013-03-14
申请号：US13229408
申请日：2011-09-09
申请人： Liexiang Fan , Paul Freiburger , John Benson
发明人： Liexiang Fan , Paul Freiburger , John Benson
IPC分类号： A61B8/00
CPC分类号： G01S7/52036 , A61B8/0858 , A61B8/14 , A61B8/485 , A61B8/5207 , A61B8/5223 , G01S7/52022 , G03B42/06
摘要： Classification preprocessing is provided for medical ultrasound shear wave imaging. In response to stress, the displacement at one or more locations in a patient is measured. The displacement over time is a curve representing a shift in location. One or more characteristics of the curve, such as signal-to-noise ratio and maximum displacement, are used to classify the location. The location is classified as fluid or fluid tissue, solid tissue, or non-determinative. Subsequent shear imaging may provide shear information for locations of solid tissue and not at other locations.
摘要翻译： 为医学超声剪切波成像提供分类预处理。 响应于应力，测量患者中一个或多个位置处的位移。 时间上的位移是表示位置偏移的曲线。 使用曲线的一个或多个特征，例如信噪比和最大位移，用于对位置进行分类。 该位置被分类为流体或流体组织，固体组织或非决定性的。 随后的剪切成像可以为固体组织的位置提供剪切信息，而不是在其他位置。
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公开(公告)号：US10278671B2
公开(公告)日：2019-05-07
申请号：US14042424
申请日：2013-09-30
申请人： Liexiang Fan , Seungsoo Kim , Nikolas Ivancevich
发明人： Liexiang Fan , Seungsoo Kim , Nikolas Ivancevich
摘要： Shear waves are detected with ultrasound. The detection of the shear wave is constrained using prior measurements in a more controlled environment (e.g., less noise). For example, shear waves measured in a phantom are used to constrain the detection of shear waves in a patient to avoid false positive detections.
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公开(公告)号：US08961418B2
公开(公告)日：2015-02-24
申请号：US12898957
申请日：2010-10-06
申请人： Liexiang Fan
发明人： Liexiang Fan
CPC分类号： A61B8/485 , A61B8/14 , A61B8/488 , G01S7/52042 , G01S15/8906 , G06F19/00
摘要： A shear wave velocity solution is provided for medical ultrasound imaging. Rather than determining shear wave information for each location based on distance from the origin of the shear wave and time to peak displacement for the location, displacement profiles resulting from different combinations of origin and detection locations are correlated. Shear information is detected using displacements from a diverse spatial combination of transmission locations and detection locations. The correlation combination is used in a same function for simultaneously solving for the delays for multiple lateral locations. Spatial diversity and layered correlation may provide for more accurate shear wave estimation.
摘要翻译： 提供用于医学超声成像的剪切波速度解决方案。 与根据距离原始的剪切波的距离以及位置的时间到峰值位移的距离确定每个位置的剪切波信息而不是根据不同原点和检测位置的组合产生的位移曲线相关。 使用来自传输位置和检测位置的不同空间组合的位移来检测剪切信息。 相关组合用于相同的功能，用于同时求解多个横向位置的延迟。 空间分集和分层相关可以提供更准确的剪切波估计。
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