公开(公告)号：US06689802B2

公开(公告)日：2004-02-10

申请号：US09925112

申请日：2001-08-09

申请人： John D. DiMarco ,  Jack Z. Gougoutas ,  Imre M. Vitez ,  Martha Davidovich ,  Michael A. Galella ,  Timothy M. Malloy ,  Zhenrong Guo ,  Denis Favreau

发明人： John D. DiMarco ,  Jack Z. Gougoutas ,  Imre M. Vitez ,  Martha Davidovich ,  Michael A. Galella ,  Timothy M. Malloy ,  Zhenrong Guo ,  Denis Favreau

IPC分类号： C07D49304

CPC分类号： C07D491/04 ,  C07D417/06

摘要： There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are methods of forming the novel polymorphs, therapeutic methods utilizing them and pharmaceutical dosage forms containing them.

摘要翻译： 根据本发明，提供了分别由式表示的埃坡霉素类似物的分别称为A型和B型的两种结晶多晶型物及其混合物，还提供形成新型多晶型物的方法，利用它们的治疗方法和 含有它们的药物剂型。

公开(公告)号：US07153879B2

公开(公告)日：2006-12-26

申请号：US11271456

申请日：2005-11-10

申请人： John D. DiMarco ,  Jack Z. Gougoutas ,  Imre M. Vitez ,  Martha Davidovich ,  Michael A. Galella ,  Timothy M. Malloy ,  Zhenrong Guo ,  Denis Favreau

发明人： John D. DiMarco ,  Jack Z. Gougoutas ,  Imre M. Vitez ,  Martha Davidovich ,  Michael A. Galella ,  Timothy M. Malloy ,  Zhenrong Guo ,  Denis Favreau

IPC分类号： C07D493/04 ,  A61K31/42 ,  A61P35/00

CPC分类号： C07D491/04 ,  C07D417/06

摘要： There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are methods of forming the novel polymorphs, therapeutic methods utilizing them and pharmaceutical dosage forms containing them.

公开(公告)号：US06982276B2

公开(公告)日：2006-01-03

申请号：US10773819

申请日：2004-02-06

申请人： John D. DiMarco ,  Jack Z. Gougoutas ,  Imre M. Vitez ,  Martha Davidovich ,  Michael A. Galella ,  Timothy M. Malloy ,  Zhenrong Guo ,  Denis Favreau

发明人： John D. DiMarco ,  Jack Z. Gougoutas ,  Imre M. Vitez ,  Martha Davidovich ,  Michael A. Galella ,  Timothy M. Malloy ,  Zhenrong Guo ,  Denis Favreau

IPC分类号： C07D493/04 ,  A61K31/42

CPC分类号： C07D491/04 ,  C07D417/06

摘要： There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are methods of forming the novel polymorphs, therapeutic methods utilizing them and pharmaceutical dosage forms containing them.