公开(公告)号：US4871771A

公开(公告)日：1989-10-03

申请号：US152191

申请日：1988-02-04

申请人： John G. Gleason ,  Sylvia T. Hoffstein ,  Charles M. Kinzig ,  Seymour Mong ,  Henry M. Sarau

发明人： John G. Gleason ,  Sylvia T. Hoffstein ,  Charles M. Kinzig ,  Seymour Mong ,  Henry M. Sarau

IPC分类号： A61K31/19 ,  A61P9/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C323/56

CPC分类号： A61K31/19

摘要： A method for inhibiting the effects of LTB.sub.4 comprises administration of an effective amount of a compound represented by the following structural formula (I) ##STR1## wherein m is 1 or 2; n is 1, 2 or 3; p is 0, 1, or 2; R' is hydrogen or methyl; R is phenyl substituted with A, R.sub.1 and R.sub.2 wherein R.sub.1 and R.sub.2 are independently selected from either (1) (S).sub.a --(CH.sub.2).sub.b --(T).sub.c --B wherein a is 0 or 1; b is 5 to 12; c is 0 or 1; S and T are independently sulfur, oxygen, or CH.sub.2 with the proviso that S or T are not sulfur when p is 1 or 2; and B is C.sub.1-4 alkyl, ethynyl, trifluoromethyl, or phenyl optionally monosubstituted with Br, Cl, CF.sub.3, C.sub.1-4 alkoxy, C.sub.1-4 alkyl, methylthio, or trifluoromethylthio; or (2) hydrogen bromo, chloro, methyl, trifluoromethyl, methoxy or nitro; and A is selected from (2) as defined above or a pharmaceutically acceptable salt thereof. Such methods are useful in the treatment of diseases in which LTB.sub.4 is a factor.